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• W3198177584 abstract "Abstract Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC 90 value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans." @default.
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• W3198177584 date "2021-09-10" @default.
• W3198177584 modified "2023-10-02" @default.
• W3198177584 title "Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro" @default.
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• W3198177584 doi "https://doi.org/10.1038/s41598-021-97658-w" @default.
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