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- W3198179210 abstract "Objective
 We aimed to evaluate the correlation between the
 immunohistochemical expressions of MLH1, PMS2,
 MSH6, MSH2 and clinicopathological parameters in
 gastric carcinoma.
 Matherials and Methods
 Immunohistochemistry was performed on the tissue
 microarray (TMA) sections of 103 primary gastric
 adenocarcinoma and 27 gastric mucosal tissue
 samples without tumor. All markers were evaluated
 for the presence of nuclear staining. Negative expression
 in any of the markers was accepted as a
 deficiency. Then, the comparison was made between
 the two subgroups as; deficient mismatch repair
 (dMMR) and proficient mismatch repair (pMMR).
 Results
 The histopathological subtypes as intestinal and
 non-intestinal, the intestinal group showed significant
 deficient expression of MSH2 compared with
 the non-intestinal group. PMS2 expression was significantly
 higher in the other subtypes than signet ring
 cell carcinoma. Also, we observed that the loss of
 MLH1 and PMS2 expressions were higher in moderately/
 poor differantiated tumors than the well differantiated
 ones. Perineural invasion was significantly
 higher in patients with loss of MLH1, MSH6, PMS2
 expression and dMMR compared to patients with
 pMMR. There was no significant difference between
 dMMR and pMMR when compared the groups
 who received chemotherapy/ radiotherapy and who
 did not. There was not found significant relationship
 between MLH1, MSH2, MSH6, PMS2 expressions
 and survival.
 Conclusion
 We found a significant relationship between perineural
 invasion and the loss of expression of MLH1,
 MSH6 and PMS2. PMS2 expression was also significantly
 higher in the other subtypes of GC than signet
 ring cell carcinomas." @default.
- W3198179210 created "2021-09-13" @default.
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- W3198179210 date "2021-09-13" @default.
- W3198179210 modified "2023-10-10" @default.
- W3198179210 title "HATALI EŞLEŞME GENLERİNDEN MLH1, PMS2, MSH6, MSH2’İN MİDE KANSERLERİNDE İMMÜNHİSTOKİMYASAL EKSPRESYONU; BİR DOKU MİKROARRAY ÇALIŞMASI" @default.
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- W3198179210 doi "https://doi.org/10.17343/sdutfd.866797" @default.
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