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- W3198184583 abstract "We report on the utility of Radiofrequency Amplification by Stimulated Emission Radiation (RASER) for background-free proton detection of hyperpolarized biomolecules. We performed hyperpolarization of ≈0.3 M ethyl acetate via pairwise parahydrogen addition to vinyl acetate. A proton NMR signal with signal-to-noise ratio exceeding 100 000 was detected without radio-frequency excitation at the clinically relevant magnetic field of 1.4 T using a standard (non-cryogenic) inductive detector with quality factor of Q=68. No proton background signal was observed from protonated solvent (methanol) or other added co-solvents such as ethanol, water or bovine serum. Moreover, we demonstrate RASER detection without radio-frequency excitation of a bolus of hyperpolarized contrast agent in biological fluid. Completely background-free proton detection of hyperpolarized contrast agents in biological media paves the way to new applications in the areas of high-resolution NMR spectroscopy and in vivo spectroscopy and imaging." @default.
- W3198184583 created "2021-09-13" @default.
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- W3198184583 date "2021-10-01" @default.
- W3198184583 modified "2023-10-14" @default.
- W3198184583 title "Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation" @default.
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- W3198184583 doi "https://doi.org/10.1002/anie.202108939" @default.
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