FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198189098> ?p ?o ?g. }

• W3198189098 endingPage "492" @default.
• W3198189098 startingPage "485" @default.
• W3198189098 abstract "The randomized controlled trial is the quintessential scientific tool to evaluate the effectiveness and safety of medications. While early trials of drugs used for the treatment of chronic obstructive pulmonary disease (COPD) and other respiratory diseases were generally unambiguous, more recent studies have been controversial. It has become evident that the conduct, design and analysis of these trials were highly variable and may have been responsible for incoherencies in results and interpretation. With the advent of new studies, the need for guiding principles for the conduct of future randomized trials has become manifest. We describe the concept of the counterfactual principle as it applies to the treatment of patients and to the randomized trial. We then present ten methodological tenets for the design and statistical aspects of randomized controlled trials evaluating the effectiveness of drugs used in the treatment of several respiratory diseases. They include eight study design and two statistical analysis principles: 1) Study question; 2) Intervention; 3) Study population; 4) Blinding; 5) Run-in period; 6) Follow-up; 7) Outcome; 8) Safety; 9) Intent-to-treat; 10) Covariate adjustment. These tenets are described using mainly examples from trials of pharmacological treatments for COPD, as well as some from asthma and idiopathic pulmonary fibrosis, conducted over the last 30 years. The careful application of these principles in the conduct of randomized trials will provide rigorous studies and improve the validity of results. The ensuing clearer interpretation of findings will permit their well-founded contribution to treatment guidelines and optimal clinical management." @default.
• W3198189098 created "2021-09-13" @default.
• W3198189098 creator A5008217187 @default.
• W3198189098 date "2021-09-01" @default.
• W3198189098 modified "2023-09-23" @default.
• W3198189098 title "Ten Commandments for Randomized Trials of Pharmacological Therapy for COPD and Other Lung Diseases" @default.
• W3198189098 cites W1548901178 @default.
• W3198189098 cites W1561387674 @default.
• W3198189098 cites W1987555297 @default.
• W3198189098 cites W1989877439 @default.
• W3198189098 cites W2008414374 @default.
• W3198189098 cites W2009432182 @default.
• W3198189098 cites W2019271924 @default.
• W3198189098 cites W2027624580 @default.
• W3198189098 cites W2047240089 @default.
• W3198189098 cites W2070935883 @default.
• W3198189098 cites W2081806742 @default.
• W3198189098 cites W2095052694 @default.
• W3198189098 cites W2096723137 @default.
• W3198189098 cites W2103823880 @default.
• W3198189098 cites W2104636056 @default.
• W3198189098 cites W2105191262 @default.
• W3198189098 cites W2107025270 @default.
• W3198189098 cites W2107103531 @default.
• W3198189098 cites W2108426443 @default.
• W3198189098 cites W2118939220 @default.
• W3198189098 cites W2121671594 @default.
• W3198189098 cites W2124884121 @default.
• W3198189098 cites W2125779455 @default.
• W3198189098 cites W2127791137 @default.
• W3198189098 cites W2129042008 @default.
• W3198189098 cites W2134492231 @default.
• W3198189098 cites W2136335199 @default.
• W3198189098 cites W2138871107 @default.
• W3198189098 cites W2142724633 @default.
• W3198189098 cites W2146734665 @default.
• W3198189098 cites W2153441442 @default.
• W3198189098 cites W2161984127 @default.
• W3198189098 cites W2163441905 @default.
• W3198189098 cites W2166386082 @default.
• W3198189098 cites W2172490363 @default.
• W3198189098 cites W2344148139 @default.
• W3198189098 cites W2365138737 @default.
• W3198189098 cites W2413861456 @default.
• W3198189098 cites W2512624858 @default.
• W3198189098 cites W2604743750 @default.
• W3198189098 cites W2715795126 @default.
• W3198189098 cites W2735470766 @default.
• W3198189098 cites W2756335179 @default.
• W3198189098 cites W2785999277 @default.
• W3198189098 cites W2794699839 @default.
• W3198189098 cites W2801664602 @default.
• W3198189098 cites W2802221596 @default.
• W3198189098 cites W2904259512 @default.
• W3198189098 cites W2914559404 @default.
• W3198189098 cites W3037411127 @default.
• W3198189098 cites W4302324060 @default.
• W3198189098 doi "https://doi.org/10.1080/15412555.2021.1968816" @default.
• W3198189098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34468248" @default.
• W3198189098 hasPublicationYear "2021" @default.
• W3198189098 type Work @default.
• W3198189098 sameAs 3198189098 @default.
• W3198189098 citedByCount "1" @default.
• W3198189098 countsByYear W31981890982023 @default.
• W3198189098 crossrefType "journal-article" @default.
• W3198189098 hasAuthorship W3198189098A5008217187 @default.
• W3198189098 hasConcept C126322002 @default.
• W3198189098 hasConcept C144024400 @default.
• W3198189098 hasConcept C168563851 @default.
• W3198189098 hasConcept C177713679 @default.
• W3198189098 hasConcept C1862650 @default.
• W3198189098 hasConcept C2771230 @default.
• W3198189098 hasConcept C2776042228 @default.
• W3198189098 hasConcept C2776780178 @default.
• W3198189098 hasConcept C2779318504 @default.
• W3198189098 hasConcept C2908647359 @default.
• W3198189098 hasConcept C36289849 @default.
• W3198189098 hasConcept C535046627 @default.
• W3198189098 hasConcept C71924100 @default.
• W3198189098 hasConcept C99454951 @default.
• W3198189098 hasConceptScore W3198189098C126322002 @default.
• W3198189098 hasConceptScore W3198189098C144024400 @default.
• W3198189098 hasConceptScore W3198189098C168563851 @default.
• W3198189098 hasConceptScore W3198189098C177713679 @default.
• W3198189098 hasConceptScore W3198189098C1862650 @default.
• W3198189098 hasConceptScore W3198189098C2771230 @default.
• W3198189098 hasConceptScore W3198189098C2776042228 @default.
• W3198189098 hasConceptScore W3198189098C2776780178 @default.
• W3198189098 hasConceptScore W3198189098C2779318504 @default.
• W3198189098 hasConceptScore W3198189098C2908647359 @default.
• W3198189098 hasConceptScore W3198189098C36289849 @default.
• W3198189098 hasConceptScore W3198189098C535046627 @default.
• W3198189098 hasConceptScore W3198189098C71924100 @default.
• W3198189098 hasConceptScore W3198189098C99454951 @default.
• W3198189098 hasIssue "5" @default.
• W3198189098 hasLocation W31981890981 @default.
• W3198189098 hasLocation W31981890982 @default.
• W3198189098 hasOpenAccess W3198189098 @default.

• next