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• W3198190538 endingPage "108759" @default.
• W3198190538 startingPage "108759" @default.
• W3198190538 abstract "Plasma homocysteine (Hcy) is an independent risk factor for Age related macular degeneration (AMD) and an inducer of inflammation. Homocysteine catabolism releases hydrogen sulfide (H 2 S). H 2 S has controversial effects on inflammation. In this study we have analysed the endogenous and exogenous H 2 S in modulating inflammation using adult retinal pigment epithelial (ARPE-19) cells as an in vitro model for AMD. ARPE-19 cells were treated with various concentrations of Hcy (15, 30 and 50 μM) for 3 h. Expression of Hcy transulfuration genes (CBS, CSE) by qPCR and western blot. H 2 S levels were measured using Free Radical Analyzer System (WPI, USA). The inflammatory markers (IL-6 and IL-8) were evaluated using real-time PCR and ELISA. Hcy exposure increased CBS protein expression, hydrogen sulfide levels and pro-inflammatory cytokines, modulating CBS by silencing did not alter H 2 S levels, but inhibition of CSE with PAG inhibited H 2 S production and decreased cytokine (IL-6 and IL-8) levels. On the contrary exogenous supply of hydrogen sulfide with NaHS and by compound 1c showed anti-inflammatory effects even in the presence of Hcy. This study shows that exogenous delivery of H 2 S decreases inflammation in retinal pigment epithelial cells on exposure to Hcy in ARPE-19 cells. • Homocysteine exposure augments H 2 S release and Cystathionine beta synthase (CBS) expression in ARPE-19 cells. • Inhibiting CSE on Hcy treatment brings down H 2 S release and inflammation but not with CBS Silencing. • Exogenous administration of H 2 S by compounds decreases inflammatory markers induced by Hcy." @default.
• W3198190538 created "2021-09-13" @default.
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• W3198190538 date "2021-11-01" @default.
• W3198190538 modified "2023-09-24" @default.
• W3198190538 title "Exogenous administration of hydrogen sulfide alleviates homocysteine induced inflammation in ARPE-19 cells" @default.
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• W3198190538 doi "https://doi.org/10.1016/j.exer.2021.108759" @default.
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