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- W3198214462 endingPage "20211025" @default.
- W3198214462 startingPage "20211025" @default.
- W3198214462 abstract "The landmark studies of Wiesel and Hubel in the 1960's initiated a surge of investigations into the critical period of visual cortical development, when abnormal visual experience can alter cortical structures and functions. Most studies focused on the visual cortex, with relatively little attention to subcortical structures. The goal of the present review is to elucidate neurochemical and synaptic mechanisms common to the critical periods of the visual cortex and the brain stem respiratory system in the normal rat. In both regions, the critical period is a time of (i) heightened inhibition; (ii) reduced expression of brain-derived neurotrophic factor (BDNF); and (iii) synaptic imbalance, with heightened inhibition and suppressed excitation. The last two mechanisms are contrary to the conventional premise. Synaptic imbalance renders developing neurons more vulnerable to external stressors. However, the critical period is necessary to enable each system to strengthen its circuitry, adapt to its environment, and transition from immaturity to maturity, when a state of relative synaptic balance is attained. Failure to achieve such a balance leads to neurological disorders." @default.
- W3198214462 created "2021-09-13" @default.
- W3198214462 creator A5053646636 @default.
- W3198214462 date "2021-09-08" @default.
- W3198214462 modified "2023-09-23" @default.
- W3198214462 title "The critical period: neurochemical and synaptic mechanisms shared by the visual cortex and the brain stem respiratory system" @default.
- W3198214462 cites W148261105 @default.
- W3198214462 cites W1501153304 @default.
- W3198214462 cites W1554183329 @default.
- W3198214462 cites W1569122094 @default.
- W3198214462 cites W1575167357 @default.
- W3198214462 cites W1842266333 @default.
- W3198214462 cites W1964108352 @default.
- W3198214462 cites W1966818151 @default.
- W3198214462 cites W1978804620 @default.
- W3198214462 cites W1979306444 @default.
- W3198214462 cites W1980805844 @default.
- W3198214462 cites W1981423842 @default.
- W3198214462 cites W1982280357 @default.
- W3198214462 cites W1983576445 @default.
- W3198214462 cites W1986525624 @default.
- W3198214462 cites W1991947758 @default.
- W3198214462 cites W1992580817 @default.
- W3198214462 cites W1993222366 @default.
- W3198214462 cites W1993278700 @default.
- W3198214462 cites W1994124070 @default.
- W3198214462 cites W1994892096 @default.
- W3198214462 cites W1996168091 @default.
- W3198214462 cites W2000209446 @default.
- W3198214462 cites W2001363495 @default.
- W3198214462 cites W2001952783 @default.
- W3198214462 cites W2002095654 @default.
- W3198214462 cites W2005254595 @default.
- W3198214462 cites W2009490317 @default.
- W3198214462 cites W2013377646 @default.
- W3198214462 cites W2018297305 @default.
- W3198214462 cites W2032054534 @default.
- W3198214462 cites W2035251383 @default.
- W3198214462 cites W2037289953 @default.
- W3198214462 cites W2037787382 @default.
- W3198214462 cites W2037963292 @default.
- W3198214462 cites W2038702076 @default.
- W3198214462 cites W2046314671 @default.
- W3198214462 cites W2047106071 @default.
- W3198214462 cites W2047903303 @default.
- W3198214462 cites W2051423370 @default.
- W3198214462 cites W2051869496 @default.
- W3198214462 cites W2052448876 @default.
- W3198214462 cites W2052554098 @default.
- W3198214462 cites W2055774223 @default.
- W3198214462 cites W2062511892 @default.
- W3198214462 cites W2064363302 @default.
- W3198214462 cites W2065582606 @default.
- W3198214462 cites W2072139179 @default.
- W3198214462 cites W2081070804 @default.
- W3198214462 cites W2087416422 @default.
- W3198214462 cites W2088475496 @default.
- W3198214462 cites W2089509563 @default.
- W3198214462 cites W2091376817 @default.
- W3198214462 cites W2096006516 @default.
- W3198214462 cites W2100171700 @default.
- W3198214462 cites W2100322904 @default.
- W3198214462 cites W2100617174 @default.
- W3198214462 cites W2102008265 @default.
- W3198214462 cites W2102224657 @default.
- W3198214462 cites W2108286207 @default.
- W3198214462 cites W2108470366 @default.
- W3198214462 cites W2110865466 @default.
- W3198214462 cites W2115649815 @default.
- W3198214462 cites W2116359609 @default.
- W3198214462 cites W2120301129 @default.
- W3198214462 cites W2128099883 @default.
- W3198214462 cites W2128676313 @default.
- W3198214462 cites W2128840781 @default.
- W3198214462 cites W2131899586 @default.
- W3198214462 cites W2137405359 @default.
- W3198214462 cites W2146691336 @default.
- W3198214462 cites W2149776064 @default.
- W3198214462 cites W2149858533 @default.
- W3198214462 cites W2155166279 @default.
- W3198214462 cites W2156864435 @default.
- W3198214462 cites W2156979070 @default.
- W3198214462 cites W2167182086 @default.
- W3198214462 cites W2188183548 @default.
- W3198214462 cites W2210077847 @default.
- W3198214462 cites W2236404340 @default.
- W3198214462 cites W2320983896 @default.
- W3198214462 cites W2324922607 @default.
- W3198214462 cites W2395878893 @default.
- W3198214462 cites W2401943522 @default.
- W3198214462 cites W2555498209 @default.
- W3198214462 cites W2574408041 @default.
- W3198214462 cites W2610263234 @default.
- W3198214462 cites W2766063118 @default.
- W3198214462 cites W2799533278 @default.
- W3198214462 cites W2800803905 @default.
- W3198214462 cites W2883560622 @default.
- W3198214462 cites W2889814193 @default.