Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198218354> ?p ?o ?g. }
- W3198218354 abstract "ABSTRACT Human herpesvirus 8 (HHV-8) is an oncogenic virus that enters cells by fusion of the viral and endosomal cellular membranes in a process mediated by viral surface glycoproteins. One of the cellular receptors hijacked by HHV-8 to gain access to cells is the EphA2 tyrosine kinase receptor, and the mechanistic basis of EphA2-mediated viral entry remains unclear. Using X-ray structure analysis, targeted mutagenesis and binding studies, we here show that the HHV-8 envelope glycoprotein complex gH/gL binds with sub-nanomolar affinity to EphA2 via molecular mimicry of the receptor’s cellular ligands, ephrins, revealing a pivotal role for the conserved gH residue E52 and the amino-terminal peptide of gL. Using FSI-FRET and cell contraction assays, we further demonstrate that the gH/gL complex also functionally mimics ephrin ligand by inducing EphA2 receptor association via its dimerization interface, thus triggering receptor signaling for cytoskeleton remodeling. These results now provide novel insight into the entry mechanism of HHV-8, opening avenues for the search of therapeutic agents that could interfere with HHV-8 related diseases." @default.
- W3198218354 created "2021-09-13" @default.
- W3198218354 creator A5000748364 @default.
- W3198218354 creator A5010280184 @default.
- W3198218354 creator A5027148995 @default.
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- W3198218354 creator A5075289310 @default.
- W3198218354 creator A5075457982 @default.
- W3198218354 creator A5087597957 @default.
- W3198218354 creator A5090693818 @default.
- W3198218354 date "2021-03-28" @default.
- W3198218354 modified "2023-09-23" @default.
- W3198218354 title "Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling" @default.
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