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- W3198232877 endingPage "112095" @default.
- W3198232877 startingPage "112095" @default.
- W3198232877 abstract "Hyaluronan is a non-sulfated negatively-charged linear polymer distributed in most parts of the human body, where it is located around cells in the extracellular matrix of connective tissues and plays an essential role in the organization of tissue architecture. Moreover, hyaluronan is involved in many biological processes and used in many clinical, cosmetic, pharmaceutic, and biotechnological applications worldwide. As interest in hyaluronan applications increases, so does interest in hyaluronidases and hyaluronate lyases, as these enzymes play a major part in hyaluronan degradation. Many hyaluronidases and hyaluronate lyases produced by eukaryotic cells, bacteria, and bacteriophages have so far been described and annotated, and their ability to cleave hyaluronan has been experimentally proven. These enzymes belong to several carbohydrate-active enzyme families, share very low sequence identity, and differ in their cleaving mechanisms and in their structural and functional properties. This review presents a summary of annotated and characterized hyaluronidases and hyaluronate lyases isolated from different sources belonging to distinct protein families, with a main focus on the binding and catalytic residues of the discussed enzymes in the context of their biochemical properties. In addition, the application potential of individual groups of hyaluronidases and hyaluronate lyases is evaluated." @default.
- W3198232877 created "2021-09-13" @default.
- W3198232877 creator A5038635122 @default.
- W3198232877 creator A5044369975 @default.
- W3198232877 creator A5053307676 @default.
- W3198232877 creator A5072593349 @default.
- W3198232877 creator A5087734309 @default.
- W3198232877 date "2021-12-01" @default.
- W3198232877 modified "2023-10-18" @default.
- W3198232877 title "Hyaluronidases and hyaluronate lyases: From humans to bacteriophages" @default.
- W3198232877 cites W1088277555 @default.
- W3198232877 cites W1495367495 @default.
- W3198232877 cites W1679358535 @default.
- W3198232877 cites W1832927978 @default.
- W3198232877 cites W1857570296 @default.
- W3198232877 cites W1879260991 @default.
- W3198232877 cites W1918498338 @default.
- W3198232877 cites W1945011216 @default.
- W3198232877 cites W1964632662 @default.
- W3198232877 cites W1966334497 @default.
- W3198232877 cites W1968202154 @default.
- W3198232877 cites W1970995209 @default.
- W3198232877 cites W1971939635 @default.
- W3198232877 cites W1973354779 @default.
- W3198232877 cites W1974295442 @default.
- W3198232877 cites W1977477813 @default.
- W3198232877 cites W1979324249 @default.
- W3198232877 cites W1980892229 @default.
- W3198232877 cites W1986295494 @default.
- W3198232877 cites W1988306472 @default.
- W3198232877 cites W1989565018 @default.
- W3198232877 cites W1990762118 @default.
- W3198232877 cites W1991898816 @default.
- W3198232877 cites W1994175552 @default.
- W3198232877 cites W1996462110 @default.
- W3198232877 cites W1996585644 @default.
- W3198232877 cites W1997096247 @default.
- W3198232877 cites W2000483651 @default.
- W3198232877 cites W2002339965 @default.
- W3198232877 cites W2003380614 @default.
- W3198232877 cites W2005318950 @default.
- W3198232877 cites W2007233447 @default.
- W3198232877 cites W2009163367 @default.
- W3198232877 cites W2011488277 @default.
- W3198232877 cites W2012879220 @default.
- W3198232877 cites W2015216864 @default.
- W3198232877 cites W2021393975 @default.
- W3198232877 cites W2022686800 @default.
- W3198232877 cites W2025601448 @default.
- W3198232877 cites W2027092476 @default.
- W3198232877 cites W2027206556 @default.
- W3198232877 cites W2031225659 @default.
- W3198232877 cites W2034382770 @default.
- W3198232877 cites W2037569471 @default.
- W3198232877 cites W2040285608 @default.
- W3198232877 cites W2042012402 @default.
- W3198232877 cites W2042376275 @default.
- W3198232877 cites W2048571383 @default.
- W3198232877 cites W2051042723 @default.
- W3198232877 cites W2051048339 @default.
- W3198232877 cites W2051287611 @default.
- W3198232877 cites W2052140018 @default.
- W3198232877 cites W2056323304 @default.
- W3198232877 cites W2056488583 @default.
- W3198232877 cites W2065895195 @default.
- W3198232877 cites W2066113075 @default.
- W3198232877 cites W2068704923 @default.
- W3198232877 cites W2068840229 @default.
- W3198232877 cites W2075500360 @default.
- W3198232877 cites W2076036875 @default.
- W3198232877 cites W2078501511 @default.
- W3198232877 cites W2080337585 @default.
- W3198232877 cites W2084034491 @default.
- W3198232877 cites W2084366835 @default.
- W3198232877 cites W2084375793 @default.
- W3198232877 cites W2087421200 @default.
- W3198232877 cites W2091083196 @default.
- W3198232877 cites W2091359958 @default.
- W3198232877 cites W2091363753 @default.
- W3198232877 cites W2093270567 @default.
- W3198232877 cites W2097847761 @default.
- W3198232877 cites W2103083343 @default.
- W3198232877 cites W2105393937 @default.
- W3198232877 cites W2106882534 @default.
- W3198232877 cites W2109277282 @default.
- W3198232877 cites W2118468892 @default.
- W3198232877 cites W2120772351 @default.
- W3198232877 cites W2122090590 @default.
- W3198232877 cites W2122559203 @default.
- W3198232877 cites W2123158441 @default.
- W3198232877 cites W2123167146 @default.
- W3198232877 cites W2127235556 @default.
- W3198232877 cites W2127466034 @default.
- W3198232877 cites W2128881726 @default.
- W3198232877 cites W2134935071 @default.
- W3198232877 cites W2136935081 @default.
- W3198232877 cites W2139835831 @default.
- W3198232877 cites W2144370911 @default.