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- W3198264213 abstract "Abstract Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males. Since BCa and PCa cases are mainly diagnosed in advanced stages with clinical complications, it is required to introduce the efficient early detection markers. Protein kinases are critical factors involved in various cellular processes such as cell growth, motility, differentiation, and metabolism. Deregulation of protein kinases can be frequently observed through the neoplastic transformation and tumor progression. Therefore, kinases are required to be regulated via different genetic and epigenetic processes. MicroRNAs (miRNAs) are among the critical factors involved in epigenetic regulation of protein kinases. Since miRNAs are noninvasive and more stable factors in serum and tissues compared with mRNAs, they can be used as efficient diagnostic markers for the early detection of PCa and BCa. Main body In present review, we have summarized all of the reported miRNAs that have been associated with regulation of protein kinases in bladder and prostate cancers. Conclusions For the first time, this review highlights the miRNAs as critical factors in regulation of protein kinases during prostate and bladder cancers which paves the way of introducing a noninvasive kinase-specific panel of miRNAs for the early detection of these malignancies. It was observed that the class VIII receptors of tyrosine kinases and non-receptor tyrosine kinases were the most frequent targets for the miRNAs in bladder and prostate cancers, respectively." @default.
- W3198264213 created "2021-09-13" @default.
- W3198264213 creator A5040629805 @default.
- W3198264213 creator A5063240624 @default.
- W3198264213 creator A5070203910 @default.
- W3198264213 creator A5087245245 @default.
- W3198264213 date "2021-09-08" @default.
- W3198264213 modified "2023-10-16" @default.
- W3198264213 title "MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers" @default.
- W3198264213 cites W144423133 @default.
- W3198264213 cites W1490283529 @default.
- W3198264213 cites W1535671294 @default.
- W3198264213 cites W1596261235 @default.
- W3198264213 cites W1597895778 @default.
- W3198264213 cites W1599073270 @default.
- W3198264213 cites W1649526546 @default.
- W3198264213 cites W1654844775 @default.
- W3198264213 cites W170658128 @default.
- W3198264213 cites W1710517486 @default.
- W3198264213 cites W1824707126 @default.
- W3198264213 cites W1841030365 @default.
- W3198264213 cites W1920968130 @default.
- W3198264213 cites W1965784823 @default.
- W3198264213 cites W1967803088 @default.
- W3198264213 cites W1974024530 @default.
- W3198264213 cites W1974963898 @default.
- W3198264213 cites W1979501382 @default.
- W3198264213 cites W1982619307 @default.
- W3198264213 cites W1982898420 @default.
- W3198264213 cites W1984382686 @default.
- W3198264213 cites W1986324141 @default.
- W3198264213 cites W1987681742 @default.
- W3198264213 cites W1990134250 @default.
- W3198264213 cites W1990848928 @default.
- W3198264213 cites W1992344857 @default.
- W3198264213 cites W1998238618 @default.
- W3198264213 cites W1999053142 @default.
- W3198264213 cites W2002645985 @default.
- W3198264213 cites W2007266898 @default.
- W3198264213 cites W2010427019 @default.
- W3198264213 cites W2015182899 @default.
- W3198264213 cites W2018723470 @default.
- W3198264213 cites W2021170166 @default.
- W3198264213 cites W2030205108 @default.
- W3198264213 cites W2030705338 @default.
- W3198264213 cites W2033987156 @default.
- W3198264213 cites W2036801235 @default.
- W3198264213 cites W2042011375 @default.
- W3198264213 cites W2042369991 @default.
- W3198264213 cites W2042761540 @default.
- W3198264213 cites W2043082218 @default.
- W3198264213 cites W2048556644 @default.
- W3198264213 cites W2049850006 @default.
- W3198264213 cites W2051041196 @default.
- W3198264213 cites W2051877908 @default.
- W3198264213 cites W2053116646 @default.
- W3198264213 cites W2053317015 @default.
- W3198264213 cites W2053525092 @default.
- W3198264213 cites W2053607252 @default.
- W3198264213 cites W2059550947 @default.
- W3198264213 cites W2064041964 @default.
- W3198264213 cites W2064352891 @default.
- W3198264213 cites W2064492560 @default.
- W3198264213 cites W2065102088 @default.
- W3198264213 cites W2065916018 @default.
- W3198264213 cites W2067053182 @default.
- W3198264213 cites W2067337319 @default.
- W3198264213 cites W2069180517 @default.
- W3198264213 cites W2069421644 @default.
- W3198264213 cites W2069698030 @default.
- W3198264213 cites W2073100248 @default.
- W3198264213 cites W2074161778 @default.
- W3198264213 cites W2079588482 @default.
- W3198264213 cites W2080951155 @default.
- W3198264213 cites W2081365151 @default.
- W3198264213 cites W2081476178 @default.
- W3198264213 cites W2084030328 @default.
- W3198264213 cites W2084265884 @default.
- W3198264213 cites W2090046134 @default.
- W3198264213 cites W2096504277 @default.
- W3198264213 cites W2098371517 @default.
- W3198264213 cites W2098545015 @default.
- W3198264213 cites W2100970263 @default.
- W3198264213 cites W2101995865 @default.
- W3198264213 cites W2103324798 @default.
- W3198264213 cites W2103810253 @default.
- W3198264213 cites W2107168679 @default.
- W3198264213 cites W2107633226 @default.
- W3198264213 cites W2107972068 @default.
- W3198264213 cites W2108131308 @default.
- W3198264213 cites W2108693838 @default.
- W3198264213 cites W2111631361 @default.
- W3198264213 cites W2115840640 @default.
- W3198264213 cites W2116478904 @default.
- W3198264213 cites W2118126511 @default.
- W3198264213 cites W2120366499 @default.
- W3198264213 cites W2121514501 @default.
- W3198264213 cites W2122014435 @default.
- W3198264213 cites W2126315841 @default.
- W3198264213 cites W2127089802 @default.