FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198271129> ?p ?o ?g. }

• W3198271129 abstract "Abstract Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively transferred tumor-reactive T cells. As anti-CD4 monoclonal antibody depletes CD4 + immune-suppressive cells, the combination of anti-CD4 treatment and ACT has synergistic potential in cancer therapy. Here, we demonstrate a post-ACT conditioning regimen that involves transient anti-CD4 treatment (CD4 post ). Using murine melanoma, the combined effect of cyclophosphamide preconditioning (CTX pre ), CD4 post , and ex vivo primed tumor-reactive CD8 + T-cell infusion is presented. CTX pre /CD4 post increases tumor suppression and host survival by accelerating the proliferation and differentiation of ex vivo primed CD8 + T cells and endogenous CD8 + T cells. Endogenous CD8 + T cells enhance effector profile and tumor-reactivity, indicating skewing of the TCR repertoire. Notably, enrichment of polyfunctional IL-18Rα hi CD8 + T cell subset is the key event in CTX pre /CD4 post -induced tumor suppression. Mechanistically, the anti-tumor effect of IL-18Rα hi subset is mediated by IL-18 signaling and TCR–MHC I interaction. This study highlights the clinical relevance of CD4 post in ACT and provides insights regarding the immunological nature of anti-CD4 treatment, which enhances anti-tumor response of CD8 + T cells." @default.
• W3198271129 created "2021-09-13" @default.
• W3198271129 creator A5040887553 @default.
• W3198271129 creator A5043780534 @default.
• W3198271129 creator A5049494424 @default.
• W3198271129 creator A5071728483 @default.
• W3198271129 creator A5086189608 @default.
• W3198271129 creator A5087570120 @default.
• W3198271129 date "2021-09-07" @default.
• W3198271129 modified "2023-10-15" @default.
• W3198271129 title "Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells" @default.
• W3198271129 cites W1483573531 @default.
• W3198271129 cites W1493822493 @default.
• W3198271129 cites W1544307647 @default.
• W3198271129 cites W1601504908 @default.
• W3198271129 cites W1981393767 @default.
• W3198271129 cites W1990602451 @default.
• W3198271129 cites W1993193500 @default.
• W3198271129 cites W2000297273 @default.
• W3198271129 cites W2008667095 @default.
• W3198271129 cites W2012016042 @default.
• W3198271129 cites W2042930095 @default.
• W3198271129 cites W2046041427 @default.
• W3198271129 cites W2052558938 @default.
• W3198271129 cites W2053967595 @default.
• W3198271129 cites W2067650601 @default.
• W3198271129 cites W2070658613 @default.
• W3198271129 cites W2076920621 @default.
• W3198271129 cites W2094955298 @default.
• W3198271129 cites W2103176338 @default.
• W3198271129 cites W2105548504 @default.
• W3198271129 cites W2106511557 @default.
• W3198271129 cites W2124373740 @default.
• W3198271129 cites W2127734125 @default.
• W3198271129 cites W2132207502 @default.
• W3198271129 cites W2141664407 @default.
• W3198271129 cites W2143675098 @default.
• W3198271129 cites W2145866317 @default.
• W3198271129 cites W2156491299 @default.
• W3198271129 cites W2164364292 @default.
• W3198271129 cites W2280417087 @default.
• W3198271129 cites W2302088846 @default.
• W3198271129 cites W2472697448 @default.
• W3198271129 cites W2514996992 @default.
• W3198271129 cites W2561054909 @default.
• W3198271129 cites W2565855748 @default.
• W3198271129 cites W2578528809 @default.
• W3198271129 cites W2604931745 @default.
• W3198271129 cites W2612525958 @default.
• W3198271129 cites W2782242719 @default.
• W3198271129 cites W2783035773 @default.
• W3198271129 cites W2787621143 @default.
• W3198271129 cites W2793959072 @default.
• W3198271129 cites W2801130378 @default.
• W3198271129 cites W2808421749 @default.
• W3198271129 cites W2899702946 @default.
• W3198271129 cites W2912053941 @default.
• W3198271129 cites W2982049472 @default.
• W3198271129 cites W3037257919 @default.
• W3198271129 cites W3091982740 @default.
• W3198271129 cites W4242789072 @default.
• W3198271129 doi "https://doi.org/10.1038/s41467-021-25559-7" @default.
• W3198271129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8423719" @default.
• W3198271129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34493727" @default.
• W3198271129 hasPublicationYear "2021" @default.
• W3198271129 type Work @default.
• W3198271129 sameAs 3198271129 @default.
• W3198271129 citedByCount "10" @default.
• W3198271129 countsByYear W31982711292021 @default.
• W3198271129 countsByYear W31982711292022 @default.
• W3198271129 countsByYear W31982711292023 @default.
• W3198271129 crossrefType "journal-article" @default.
• W3198271129 hasAuthorship W3198271129A5040887553 @default.
• W3198271129 hasAuthorship W3198271129A5043780534 @default.
• W3198271129 hasAuthorship W3198271129A5049494424 @default.
• W3198271129 hasAuthorship W3198271129A5071728483 @default.
• W3198271129 hasAuthorship W3198271129A5086189608 @default.
• W3198271129 hasAuthorship W3198271129A5087570120 @default.
• W3198271129 hasBestOaLocation W31982711291 @default.
• W3198271129 hasConcept C129374314 @default.
• W3198271129 hasConcept C150903083 @default.
• W3198271129 hasConcept C154317977 @default.
• W3198271129 hasConcept C167672396 @default.
• W3198271129 hasConcept C202751555 @default.
• W3198271129 hasConcept C203014093 @default.
• W3198271129 hasConcept C207001950 @default.
• W3198271129 hasConcept C26291073 @default.
• W3198271129 hasConcept C2776090121 @default.
• W3198271129 hasConcept C2777701055 @default.
• W3198271129 hasConcept C502942594 @default.
• W3198271129 hasConcept C55493867 @default.
• W3198271129 hasConcept C86803240 @default.
• W3198271129 hasConcept C8840205 @default.
• W3198271129 hasConcept C8891405 @default.
• W3198271129 hasConcept C90375314 @default.
• W3198271129 hasConceptScore W3198271129C129374314 @default.
• W3198271129 hasConceptScore W3198271129C150903083 @default.
• W3198271129 hasConceptScore W3198271129C154317977 @default.
• W3198271129 hasConceptScore W3198271129C167672396 @default.
• W3198271129 hasConceptScore W3198271129C202751555 @default.

• next