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- W3198280675 abstract "The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in the manufacture of plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, and asthma, for which inflammation has been described to be a driving factor. The emerging alternative plasticizer 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on the immune system. Here, we investigated the effects of DINCH and its naturally occurring metabolite monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to 10 nM-10 μM DINCH or MINCH for 4 h, 16 h, and 24 h. To decipher the underlying mechanism of action, we applied an untargeted proteomic approach that revealed xenobiotic-induced activation of immune-related pathways such as the nuclear factor κB (NF-κB) signaling pathway. Key drivers were associated with oxidative stress, mitochondrial dysfunction, DNA damage repair, apoptosis, and autophagy. We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-κB activation, and subsequent TNF and IL-1β release, even at low nM concentrations. Taken together, DINCH and MINCH induced cellular stress and pro-inflammatory effects in macrophages, which may lead to adverse health effects." @default.
- W3198280675 created "2021-09-13" @default.
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- W3198280675 date "2021-09-09" @default.
- W3198280675 modified "2023-10-15" @default.
- W3198280675 title "The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH Induce Oxidative Stress and Enhance Inflammatory Responses in Human THP-1 Macrophages" @default.
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- W3198280675 cites W1979784582 @default.
- W3198280675 cites W1983254116 @default.
- W3198280675 cites W1996384286 @default.
- W3198280675 cites W2026748043 @default.
- W3198280675 cites W2026988245 @default.
- W3198280675 cites W2041966702 @default.
- W3198280675 cites W2045688706 @default.
- W3198280675 cites W2053891616 @default.
- W3198280675 cites W2054540776 @default.
- W3198280675 cites W2055900364 @default.
- W3198280675 cites W2060363772 @default.
- W3198280675 cites W2063197029 @default.
- W3198280675 cites W2073563548 @default.
- W3198280675 cites W2076062022 @default.
- W3198280675 cites W2078177376 @default.
- W3198280675 cites W2083030818 @default.
- W3198280675 cites W2086667809 @default.
- W3198280675 cites W2093448443 @default.
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- W3198280675 cites W2107940314 @default.
- W3198280675 cites W2113651620 @default.
- W3198280675 cites W2122683221 @default.
- W3198280675 cites W2124348590 @default.
- W3198280675 cites W2127916470 @default.
- W3198280675 cites W2128599926 @default.
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- W3198280675 cites W2148196931 @default.
- W3198280675 cites W2151084151 @default.
- W3198280675 cites W2168205394 @default.
- W3198280675 cites W2216035725 @default.
- W3198280675 cites W2400270442 @default.
- W3198280675 cites W2401221638 @default.
- W3198280675 cites W2418211822 @default.
- W3198280675 cites W2473377022 @default.
- W3198280675 cites W2523520347 @default.
- W3198280675 cites W2614814563 @default.
- W3198280675 cites W2730923948 @default.
- W3198280675 cites W2735527928 @default.
- W3198280675 cites W2753548126 @default.
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- W3198280675 cites W2782685575 @default.
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- W3198280675 cites W2912094969 @default.
- W3198280675 cites W2959814266 @default.
- W3198280675 cites W2966844859 @default.
- W3198280675 cites W2975849704 @default.
- W3198280675 cites W2981633630 @default.
- W3198280675 cites W2982553784 @default.
- W3198280675 cites W2989782319 @default.
- W3198280675 cites W2990959265 @default.
- W3198280675 cites W2997625018 @default.
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- W3198280675 doi "https://doi.org/10.3390/cells10092367" @default.
- W3198280675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8466537" @default.
- W3198280675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34572016" @default.
- W3198280675 hasPublicationYear "2021" @default.
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