Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198321985> ?p ?o ?g. }
- W3198321985 abstract "Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the role of individual subtypes remains unclear. Here we systematically compared the capacity of distinct type I IFN subtypes to enhance T cell responses to a whole-cell vaccination strategy in a pre-clinical murine model. We show that vaccination in combination with IFNβ induces significantly greater expansion of tumor-specific CD8+ T cells than the other type I IFN subtypes tested. Optimal expansion was dependent on the presence of XCR1+ dendritic cells, CD4+ T cells, and CD40/CD40L signaling. Therapeutically, vaccination with IFNβ delayed tumor progression when compared to vaccination without IFN. When vaccinated in combination with anti-PD-L1 checkpoint blockade therapy (CPB), the inclusion of IFNβ associated with more mice experiencing complete regression and a trend in increased overall survival. This work demonstrates the potent adjuvant activity of IFNβ, highlighting its potential to enhance cancer vaccination strategies alone and in combination with CPB." @default.
- W3198321985 created "2021-09-13" @default.
- W3198321985 creator A5009794386 @default.
- W3198321985 creator A5014046203 @default.
- W3198321985 creator A5024153252 @default.
- W3198321985 creator A5024912558 @default.
- W3198321985 creator A5026627982 @default.
- W3198321985 creator A5032353557 @default.
- W3198321985 creator A5038155143 @default.
- W3198321985 creator A5041443164 @default.
- W3198321985 creator A5051172094 @default.
- W3198321985 creator A5054121448 @default.
- W3198321985 creator A5060004735 @default.
- W3198321985 creator A5060736634 @default.
- W3198321985 creator A5061342706 @default.
- W3198321985 creator A5075494481 @default.
- W3198321985 creator A5078515042 @default.
- W3198321985 date "2021-09-06" @default.
- W3198321985 modified "2023-10-05" @default.
- W3198321985 title "IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies" @default.
- W3198321985 cites W1493437706 @default.
- W3198321985 cites W1509666796 @default.
- W3198321985 cites W1527245319 @default.
- W3198321985 cites W1533531903 @default.
- W3198321985 cites W1540878706 @default.
- W3198321985 cites W1590883592 @default.
- W3198321985 cites W1611944043 @default.
- W3198321985 cites W1933156295 @default.
- W3198321985 cites W1967660147 @default.
- W3198321985 cites W1976199086 @default.
- W3198321985 cites W1976269285 @default.
- W3198321985 cites W1980704214 @default.
- W3198321985 cites W1997276741 @default.
- W3198321985 cites W2004829503 @default.
- W3198321985 cites W2007027030 @default.
- W3198321985 cites W2011458181 @default.
- W3198321985 cites W2016525911 @default.
- W3198321985 cites W2023399402 @default.
- W3198321985 cites W2029045107 @default.
- W3198321985 cites W2029184645 @default.
- W3198321985 cites W2034721703 @default.
- W3198321985 cites W2038139581 @default.
- W3198321985 cites W2043304383 @default.
- W3198321985 cites W2046505430 @default.
- W3198321985 cites W2048513925 @default.
- W3198321985 cites W2048767389 @default.
- W3198321985 cites W2052604166 @default.
- W3198321985 cites W2054265941 @default.
- W3198321985 cites W2055279578 @default.
- W3198321985 cites W2060926084 @default.
- W3198321985 cites W2065593489 @default.
- W3198321985 cites W2071606440 @default.
- W3198321985 cites W2072505780 @default.
- W3198321985 cites W2075527727 @default.
- W3198321985 cites W2087047374 @default.
- W3198321985 cites W2091018161 @default.
- W3198321985 cites W2099019634 @default.
- W3198321985 cites W2100024567 @default.
- W3198321985 cites W2100081088 @default.
- W3198321985 cites W2113180936 @default.
- W3198321985 cites W2134007339 @default.
- W3198321985 cites W2143523733 @default.
- W3198321985 cites W2150098469 @default.
- W3198321985 cites W2153503451 @default.
- W3198321985 cites W2159614234 @default.
- W3198321985 cites W2162620875 @default.
- W3198321985 cites W2164130643 @default.
- W3198321985 cites W2164462649 @default.
- W3198321985 cites W2165897342 @default.
- W3198321985 cites W2171156044 @default.
- W3198321985 cites W2229599369 @default.
- W3198321985 cites W2339763143 @default.
- W3198321985 cites W2341604280 @default.
- W3198321985 cites W2604022024 @default.
- W3198321985 cites W2724264513 @default.
- W3198321985 cites W2725988420 @default.
- W3198321985 cites W2728365508 @default.
- W3198321985 cites W2743388258 @default.
- W3198321985 cites W2746892915 @default.
- W3198321985 cites W2772677509 @default.
- W3198321985 cites W2774113098 @default.
- W3198321985 cites W2794194356 @default.
- W3198321985 cites W2808909747 @default.
- W3198321985 cites W2908629759 @default.
- W3198321985 cites W2913930303 @default.
- W3198321985 cites W2938889495 @default.
- W3198321985 cites W2946126594 @default.
- W3198321985 cites W2999263395 @default.
- W3198321985 cites W3011579833 @default.
- W3198321985 cites W3014228752 @default.
- W3198321985 doi "https://doi.org/10.3389/fimmu.2021.735133" @default.
- W3198321985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8450325" @default.
- W3198321985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34552594" @default.
- W3198321985 hasPublicationYear "2021" @default.
- W3198321985 type Work @default.
- W3198321985 sameAs 3198321985 @default.
- W3198321985 citedByCount "6" @default.
- W3198321985 countsByYear W31983219852021 @default.
- W3198321985 countsByYear W31983219852022 @default.
- W3198321985 countsByYear W31983219852023 @default.