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- W3198348221 abstract ": Kinases are pivotal regulators in tumorigenesis and metastasis by modulating the expression of oncogenes and the transcription of antioncogenes directly or indirectly. Correspondingly, multifarious 3-substituted indolin-2-one derivatives as selective kinase inhibitors for cancer therapy exhibited a low nanomolar activity with prominent efficacy, superior response rate and admirable tolerability. Particularly, certain 3-substituted indolin- 2-one derivatives have met the requirements for clinical trials or the pharmaceutical market. Herein, we focus on the traits of 3-substituted indolin-2-one derivatives as kinase inhibitors for cancer therapy, overview recent progress of 3-substituted indolin-2-one derivatives as kinase inhibitors for cancer therapy, analyze the selectivity for tyrosine kinases inhibitors and serine/threonine kinases inhibitors from the molecular aspects based on the molecular docking studies, summarize the structure-activity relationships (SARs) as selective kinase inhibitors and provide our perspectives for the development of 3- substituted indolin-2-one derivatives as kinase inhibitors for cancer therapy." @default.
- W3198348221 created "2021-09-13" @default.
- W3198348221 creator A5000324668 @default.
- W3198348221 creator A5004807635 @default.
- W3198348221 creator A5023363049 @default.
- W3198348221 date "2022-03-01" @default.
- W3198348221 modified "2023-09-23" @default.
- W3198348221 title "The Development of 3-substituted Indolin-2-one Derivatives as Kinase Inhibitors for Cancer Therapy" @default.
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