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• W3198374294 abstract "We report the rational design and synthesis of C2-modified DGJ analogues to improve the selective inhibition of human GALA over other glycosidases. We prepare these analogues using a concise route from non-carbohydrate materials and demonstrate the most selective inhibitor 7c (∼100-fold) can act in Fabry patient cells to drive reductions in levels of the disease-relevant glycolipid Gb3." @default.
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• W3198374294 date "2021-01-01" @default.
• W3198374294 modified "2023-10-15" @default.
• W3198374294 title "Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA)" @default.
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• W3198374294 doi "https://doi.org/10.1039/d1ob01526e" @default.
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