Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198388260> ?p ?o ?g. }
- W3198388260 endingPage "109040" @default.
- W3198388260 startingPage "109040" @default.
- W3198388260 abstract "Objectives To develop and validate a model for predicting the risk of early diabetic foot ulcer (DFU) based on systematic review and meta-analysis. Methods Data were analyzed from the risk factors of DFU with their corresponding risk ratio (RR) by meta-analysis. The DFU prediction model included statistically significant risk factors from the meta-analysis, all of which were scored by its weightings, and the prediction model was externally validated using a validation cohort from China. The occurrence of early DFU was defined as patients with type 2 diabetes who were free of DFU at baseline and diagnosed with DFU at follow-up. Evaluation of model performance was based on the area under the discrimination receiver operating characteristic curve (ROC), with optimal cutoff point determined by calculation of sensitivity and specificity. Kaplan–Meier curve were performed to compare the cumulative risk of different groups. Results Our meta-analysis confirmed a cumulative incidence of approximately 6.0% in 46,521 patients with diabetes. The final risk prediction model included Sex, BMI, HbA1c, Smoker, DN, DR, DPN, Intermittent Claudication, Foot care, and their RRs were 1.87, 1.08, 1.21, 1.77, 2.97, 2.98, 2.76, 3.77, 0.38, respectively. The total score of all risk factors was 80 points according to their weightings. The prediction model showed good discrimination with AUC = 0.798 (95 %CI 0.738–0.858). At the optimal cut-off value of 46.5 points, the sensitivity, specificity and Youden index were 0.769, 0.798 and 0.567, respectively. The final model stratified the validation cohort into low, low-intermediate, high-intermediate and high-risk groups; Compared with low-risk group, the RR with 95 %CI of developing DFU in high-intermediate and high-risk group were 17.23 (5.12–58.02), p < 0.01 and 46.11 (5.16–91.74), p < 0.01, respectively. Conclusion We have developed a simple tool to facilitates early identification of patients with diabetes at high risk of developing DFU based on scores. This simple tool may improve clinical decision-making and potentially guide early intervention." @default.
- W3198388260 created "2021-09-13" @default.
- W3198388260 creator A5001166216 @default.
- W3198388260 creator A5009733291 @default.
- W3198388260 creator A5037789909 @default.
- W3198388260 creator A5042673122 @default.
- W3198388260 creator A5044398622 @default.
- W3198388260 creator A5062615330 @default.
- W3198388260 creator A5062755510 @default.
- W3198388260 creator A5066059509 @default.
- W3198388260 creator A5073883248 @default.
- W3198388260 creator A5082110547 @default.
- W3198388260 creator A5086345505 @default.
- W3198388260 creator A5089792184 @default.
- W3198388260 creator A5091550310 @default.
- W3198388260 date "2021-10-01" @default.
- W3198388260 modified "2023-10-15" @default.
- W3198388260 title "Development and validation of an incidence risk prediction model for early foot ulcer in diabetes based on a high evidence systematic review and meta-analysis" @default.
- W3198388260 cites W1560874819 @default.
- W3198388260 cites W1603848210 @default.
- W3198388260 cites W1773693351 @default.
- W3198388260 cites W1786811155 @default.
- W3198388260 cites W1892066952 @default.
- W3198388260 cites W1969159744 @default.
- W3198388260 cites W1974434887 @default.
- W3198388260 cites W1978157711 @default.
- W3198388260 cites W1979423827 @default.
- W3198388260 cites W1987693671 @default.
- W3198388260 cites W2001566296 @default.
- W3198388260 cites W2019303851 @default.
- W3198388260 cites W2037195555 @default.
- W3198388260 cites W2038766392 @default.
- W3198388260 cites W2053369310 @default.
- W3198388260 cites W2064790346 @default.
- W3198388260 cites W2085939434 @default.
- W3198388260 cites W2106627941 @default.
- W3198388260 cites W2112994992 @default.
- W3198388260 cites W2113384757 @default.
- W3198388260 cites W2116057875 @default.
- W3198388260 cites W2116475791 @default.
- W3198388260 cites W2126919962 @default.
- W3198388260 cites W2127406827 @default.
- W3198388260 cites W2131226296 @default.
- W3198388260 cites W2141202798 @default.
- W3198388260 cites W2141436568 @default.
- W3198388260 cites W2141495158 @default.
- W3198388260 cites W2147663252 @default.
- W3198388260 cites W2148301082 @default.
- W3198388260 cites W2158447544 @default.
- W3198388260 cites W2160675612 @default.
- W3198388260 cites W2164949078 @default.
- W3198388260 cites W2394582105 @default.
- W3198388260 cites W2512791245 @default.
- W3198388260 cites W2552957502 @default.
- W3198388260 cites W2792815658 @default.
- W3198388260 cites W2793278118 @default.
- W3198388260 cites W2811485028 @default.
- W3198388260 cites W2972869264 @default.
- W3198388260 cites W2980708086 @default.
- W3198388260 cites W3014721260 @default.
- W3198388260 cites W3023853802 @default.
- W3198388260 cites W3091900269 @default.
- W3198388260 cites W3093325306 @default.
- W3198388260 cites W3107317679 @default.
- W3198388260 cites W3118356596 @default.
- W3198388260 cites W3122204330 @default.
- W3198388260 cites W3124510617 @default.
- W3198388260 cites W3127969440 @default.
- W3198388260 cites W3146281909 @default.
- W3198388260 cites W4242664296 @default.
- W3198388260 doi "https://doi.org/10.1016/j.diabres.2021.109040" @default.
- W3198388260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34500005" @default.
- W3198388260 hasPublicationYear "2021" @default.
- W3198388260 type Work @default.
- W3198388260 sameAs 3198388260 @default.
- W3198388260 citedByCount "17" @default.
- W3198388260 countsByYear W31983882602022 @default.
- W3198388260 countsByYear W31983882602023 @default.
- W3198388260 crossrefType "journal-article" @default.
- W3198388260 hasAuthorship W3198388260A5001166216 @default.
- W3198388260 hasAuthorship W3198388260A5009733291 @default.
- W3198388260 hasAuthorship W3198388260A5037789909 @default.
- W3198388260 hasAuthorship W3198388260A5042673122 @default.
- W3198388260 hasAuthorship W3198388260A5044398622 @default.
- W3198388260 hasAuthorship W3198388260A5062615330 @default.
- W3198388260 hasAuthorship W3198388260A5062755510 @default.
- W3198388260 hasAuthorship W3198388260A5066059509 @default.
- W3198388260 hasAuthorship W3198388260A5073883248 @default.
- W3198388260 hasAuthorship W3198388260A5082110547 @default.
- W3198388260 hasAuthorship W3198388260A5086345505 @default.
- W3198388260 hasAuthorship W3198388260A5089792184 @default.
- W3198388260 hasAuthorship W3198388260A5091550310 @default.
- W3198388260 hasConcept C120665830 @default.
- W3198388260 hasConcept C121332964 @default.
- W3198388260 hasConcept C12174686 @default.
- W3198388260 hasConcept C126322002 @default.
- W3198388260 hasConcept C134018914 @default.
- W3198388260 hasConcept C201903717 @default.