FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198420796> ?p ?o ?g. }

• W3198420796 endingPage "102128" @default.
• W3198420796 startingPage "102128" @default.
• W3198420796 abstract "Age-associated persistent ER stress is the result of declining chaperone systems of the ER that reduces cellular functions, induces apoptosis, and leads to age-related diseases. This study investigated the previously unknown regulatory mechanism of TMBIM6 during age-associated hepatic abnormalities. Wild-type (WT) and the TMBIM6 knockout (TMBIM6−/−) mice liver, human liver samples from different age groups were used to demonstrate the effect of physiological aging on liver. For TMBIM6 rescue experiments, TMBIM6−/− old mice and stable human hepatic cell lines expressing TMBIM 6 were used to study the functional role of TMBIM6 on aging-associated steatosis and its associated mechanisms. In aging humans and mice, we observed declined expression of TMBIM6 and aberrant UPR expression, which were associated with high hepatic lipid accumulation. During aging, TMBIM6-deficient mice had increased senescence than their WT counterparts. We identified redox-mediated posttranslational modifications of IRE1α such as S-nitrosylation and sulfonation were higher in TMBIM6-deficient aging mice and humans, which impaired the ER stress response signaling. Sulfonation of IRE1α enhanced regulated IRE1α-dependent decay (RIDD) activity inducing TMBIM6 decay, whereas S-nitrosylation of IRE1α inhibited XBP1 splicing enhancing the cell death. Moreover, the degradation of miR-338-3p by strong IRE1α cleavage activity enhanced the expression of PTP1B, resulting in diminishing phosphorylation of PERK. The re-expression of TMBIM6 reduced IRE1α modifications, preserved ER homeostasis, reduced senescence and senescence-associated lipid accumulation in human hepatic cells and TMBIM6-depleted mice. S-nitrosylation or sulfonation of IRE1α and its controller, the TMBIM6, might be the potential therapeutic targets for maintaining ER homeostasis in aging and aging-associated liver diseases." @default.
• W3198420796 created "2021-09-13" @default.
• W3198420796 creator A5002165527 @default.
• W3198420796 creator A5032712853 @default.
• W3198420796 creator A5036151348 @default.
• W3198420796 creator A5065929833 @default.
• W3198420796 creator A5068304729 @default.
• W3198420796 creator A5077043027 @default.
• W3198420796 date "2021-11-01" @default.
• W3198420796 modified "2023-10-16" @default.
• W3198420796 title "TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans" @default.
• W3198420796 cites W1967800198 @default.
• W3198420796 cites W1974545118 @default.
• W3198420796 cites W1975914587 @default.
• W3198420796 cites W1976496691 @default.
• W3198420796 cites W1976740634 @default.
• W3198420796 cites W2002034658 @default.
• W3198420796 cites W2007505836 @default.
• W3198420796 cites W2007813003 @default.
• W3198420796 cites W2019486401 @default.
• W3198420796 cites W2021727296 @default.
• W3198420796 cites W2022104878 @default.
• W3198420796 cites W2023148453 @default.
• W3198420796 cites W2035145212 @default.
• W3198420796 cites W2058235401 @default.
• W3198420796 cites W2063229775 @default.
• W3198420796 cites W2064194904 @default.
• W3198420796 cites W2067082060 @default.
• W3198420796 cites W2068685847 @default.
• W3198420796 cites W2079299190 @default.
• W3198420796 cites W2086090484 @default.
• W3198420796 cites W2094395547 @default.
• W3198420796 cites W2096388436 @default.
• W3198420796 cites W2098365491 @default.
• W3198420796 cites W2107401866 @default.
• W3198420796 cites W2112605568 @default.
• W3198420796 cites W2133167615 @default.
• W3198420796 cites W2147739903 @default.
• W3198420796 cites W2150555888 @default.
• W3198420796 cites W2152311269 @default.
• W3198420796 cites W2162679859 @default.
• W3198420796 cites W2164545630 @default.
• W3198420796 cites W2184409146 @default.
• W3198420796 cites W2198998046 @default.
• W3198420796 cites W2204688218 @default.
• W3198420796 cites W2213478767 @default.
• W3198420796 cites W2325038472 @default.
• W3198420796 cites W2428955439 @default.
• W3198420796 cites W2512703206 @default.
• W3198420796 cites W2520794123 @default.
• W3198420796 cites W2599153295 @default.
• W3198420796 cites W2624997514 @default.
• W3198420796 cites W2657296316 @default.
• W3198420796 cites W2766900039 @default.
• W3198420796 cites W2787482595 @default.
• W3198420796 cites W2796127835 @default.
• W3198420796 cites W2801900479 @default.
• W3198420796 cites W2811033924 @default.
• W3198420796 cites W2917926065 @default.
• W3198420796 cites W3034240181 @default.
• W3198420796 cites W3048582952 @default.
• W3198420796 cites W3120097944 @default.
• W3198420796 cites W3126935384 @default.
• W3198420796 doi "https://doi.org/10.1016/j.redox.2021.102128" @default.
• W3198420796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8476450" @default.
• W3198420796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562874" @default.
• W3198420796 hasPublicationYear "2021" @default.
• W3198420796 type Work @default.
• W3198420796 sameAs 3198420796 @default.
• W3198420796 citedByCount "6" @default.
• W3198420796 countsByYear W31984207962022 @default.
• W3198420796 countsByYear W31984207962023 @default.
• W3198420796 crossrefType "journal-article" @default.
• W3198420796 hasAuthorship W3198420796A5002165527 @default.
• W3198420796 hasAuthorship W3198420796A5032712853 @default.
• W3198420796 hasAuthorship W3198420796A5036151348 @default.
• W3198420796 hasAuthorship W3198420796A5065929833 @default.
• W3198420796 hasAuthorship W3198420796A5068304729 @default.
• W3198420796 hasAuthorship W3198420796A5077043027 @default.
• W3198420796 hasBestOaLocation W31984207961 @default.
• W3198420796 hasConcept C126322002 @default.
• W3198420796 hasConcept C134018914 @default.
• W3198420796 hasConcept C139447449 @default.
• W3198420796 hasConcept C158617107 @default.
• W3198420796 hasConcept C170493617 @default.
• W3198420796 hasConcept C182704531 @default.
• W3198420796 hasConcept C190283241 @default.
• W3198420796 hasConcept C2776151105 @default.
• W3198420796 hasConcept C2781452922 @default.
• W3198420796 hasConcept C522857546 @default.
• W3198420796 hasConcept C55493867 @default.
• W3198420796 hasConcept C63645605 @default.
• W3198420796 hasConcept C71924100 @default.
• W3198420796 hasConcept C86803240 @default.
• W3198420796 hasConcept C95444343 @default.
• W3198420796 hasConceptScore W3198420796C126322002 @default.
• W3198420796 hasConceptScore W3198420796C134018914 @default.
• W3198420796 hasConceptScore W3198420796C139447449 @default.

• next