FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198431019> ?p ?o ?g. }

• W3198431019 endingPage "5922" @default.
• W3198431019 startingPage "5914" @default.
• W3198431019 abstract "Background: Ethanol extracted from radix of Actinidia chinensis (EERAC) has been proved to be effective to inhibit colorectal cancer (CRC). Notch signaling pathway and angiogenesis in tumors are closely related with the progression of CRC. However, if EERAC could influence CRC through Notch signaling pathway and angiogenesis remains unclear. Methods: Flow cytometry, transwell, wound healing methods were used to measure cell apoptosis, invasion, migration, and proliferation. Protein and mRNA expression were detected using qRT-PCR and western blotting. Immunofluorescence staining was applied to detect the expression of target protein in the tissues. Results: The invasion, migration, and proliferation of CRC cells were remarkably suppressed by ERRAC. Significant promotion of cell apoptosis and cell ration in S stage were observed after EERAC treatment. The Notch1/DLL4/Hes1 signaling pathway and angiogenesis were suppressed by EERAC. Overexpression of LIM domain-binding 2 (LDB2) remarkably weakened the influence of ERRAC on the viability of CRC cells. Conclusions: EERAC might suppress CRC through targeting Notch/DLL4/Hes1 pathway and inhibiting angiogenesis in tumors. This study might provide novel thought for the prevention and therapy of CRC through targeting Notch/DLL4/Hes1." @default.
• W3198431019 created "2021-09-13" @default.
• W3198431019 creator A5010411226 @default.
• W3198431019 creator A5034272853 @default.
• W3198431019 creator A5050479490 @default.
• W3198431019 creator A5066839381 @default.
• W3198431019 creator A5083596914 @default.
• W3198431019 date "2021-01-01" @default.
• W3198431019 modified "2023-10-14" @default.
• W3198431019 title "Suppression of human colon tumor by EERAC through regulating Notch/DLL4/Hes pathway inhibiting angiogenesis <i>in vivo</i>" @default.
• W3198431019 cites W1992814996 @default.
• W3198431019 cites W2005049383 @default.
• W3198431019 cites W2016387704 @default.
• W3198431019 cites W2073929498 @default.
• W3198431019 cites W2088976145 @default.
• W3198431019 cites W2131794175 @default.
• W3198431019 cites W2317582029 @default.
• W3198431019 cites W2465000744 @default.
• W3198431019 cites W2558197837 @default.
• W3198431019 cites W2560087123 @default.
• W3198431019 cites W2612443381 @default.
• W3198431019 cites W2617093818 @default.
• W3198431019 cites W2751733118 @default.
• W3198431019 cites W2755269699 @default.
• W3198431019 cites W2768063809 @default.
• W3198431019 cites W2790875654 @default.
• W3198431019 cites W2808452121 @default.
• W3198431019 cites W2810691150 @default.
• W3198431019 cites W2810971819 @default.
• W3198431019 cites W2888518905 @default.
• W3198431019 cites W2891297137 @default.
• W3198431019 cites W2899722339 @default.
• W3198431019 cites W2928160201 @default.
• W3198431019 cites W2931147244 @default.
• W3198431019 cites W2997542870 @default.
• W3198431019 cites W2997738129 @default.
• W3198431019 cites W3002486770 @default.
• W3198431019 cites W3005308785 @default.
• W3198431019 cites W3022610088 @default.
• W3198431019 cites W3037705365 @default.
• W3198431019 cites W3094599880 @default.
• W3198431019 cites W3111197682 @default.
• W3198431019 cites W3111433541 @default.
• W3198431019 doi "https://doi.org/10.7150/jca.61581" @default.
• W3198431019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8408117" @default.
• W3198431019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34476005" @default.
• W3198431019 hasPublicationYear "2021" @default.
• W3198431019 type Work @default.
• W3198431019 sameAs 3198431019 @default.
• W3198431019 citedByCount "8" @default.
• W3198431019 countsByYear W31984310192022 @default.
• W3198431019 countsByYear W31984310192023 @default.
• W3198431019 crossrefType "journal-article" @default.
• W3198431019 hasAuthorship W3198431019A5010411226 @default.
• W3198431019 hasAuthorship W3198431019A5034272853 @default.
• W3198431019 hasAuthorship W3198431019A5050479490 @default.
• W3198431019 hasAuthorship W3198431019A5066839381 @default.
• W3198431019 hasAuthorship W3198431019A5083596914 @default.
• W3198431019 hasBestOaLocation W31984310191 @default.
• W3198431019 hasConcept C121608353 @default.
• W3198431019 hasConcept C161879069 @default.
• W3198431019 hasConcept C190283241 @default.
• W3198431019 hasConcept C203014093 @default.
• W3198431019 hasConcept C2780283210 @default.
• W3198431019 hasConcept C2780394083 @default.
• W3198431019 hasConcept C502942594 @default.
• W3198431019 hasConcept C526805850 @default.
• W3198431019 hasConcept C54355233 @default.
• W3198431019 hasConcept C553184892 @default.
• W3198431019 hasConcept C55493867 @default.
• W3198431019 hasConcept C62112901 @default.
• W3198431019 hasConcept C62478195 @default.
• W3198431019 hasConcept C86803240 @default.
• W3198431019 hasConcept C95444343 @default.
• W3198431019 hasConceptScore W3198431019C121608353 @default.
• W3198431019 hasConceptScore W3198431019C161879069 @default.
• W3198431019 hasConceptScore W3198431019C190283241 @default.
• W3198431019 hasConceptScore W3198431019C203014093 @default.
• W3198431019 hasConceptScore W3198431019C2780283210 @default.
• W3198431019 hasConceptScore W3198431019C2780394083 @default.
• W3198431019 hasConceptScore W3198431019C502942594 @default.
• W3198431019 hasConceptScore W3198431019C526805850 @default.
• W3198431019 hasConceptScore W3198431019C54355233 @default.
• W3198431019 hasConceptScore W3198431019C553184892 @default.
• W3198431019 hasConceptScore W3198431019C55493867 @default.
• W3198431019 hasConceptScore W3198431019C62112901 @default.
• W3198431019 hasConceptScore W3198431019C62478195 @default.
• W3198431019 hasConceptScore W3198431019C86803240 @default.
• W3198431019 hasConceptScore W3198431019C95444343 @default.
• W3198431019 hasIssue "19" @default.
• W3198431019 hasLocation W31984310191 @default.
• W3198431019 hasLocation W31984310192 @default.
• W3198431019 hasLocation W31984310193 @default.
• W3198431019 hasOpenAccess W3198431019 @default.
• W3198431019 hasPrimaryLocation W31984310191 @default.
• W3198431019 hasRelatedWork W1978215356 @default.
• W3198431019 hasRelatedWork W2043522482 @default.
• W3198431019 hasRelatedWork W2059330780 @default.

• next