FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198457875> ?p ?o ?g. }

• W3198457875 endingPage "5366" @default.
• W3198457875 startingPage "5366" @default.
• W3198457875 abstract "Cell adhesion to stromal support and the associated intracellular signaling are central to drug resistance, therefore blocking both has been effective in increasing drug sensitization in leukemia. The stromal Ser/Thr protein kinase C (PKC) has been found to be important for conferring protection to leukemic cells. We aimed at elucidating the intracellular signals connected to cell adhesion and to stromal PKC. We found that NF-κB and Akt were up-regulated in mesenchymal stem cells (MSC) after binding of B-cell acute lymphoblastic leukemia (B-ALL) cells. Nevertheless, Akt inhibition did not induce B-ALL cell detachment. In spite of a clear activation of the NF-κB signaling pathway after B-ALL cell binding (up-regulation NF-κB1/2, and down-regulation of the IKBε and IKBα inhibitors) and an important reduction in cell adhesion after NF-κB inhibition, sensitization to the drug treatment was not observed. This was opposite to the PKC inhibitors Enzastaurin and HKPS, a novel chimeric peptide inhibitor, that were able to increase sensitization to dexamethasone, methotrexate, and vincristine. PLCγ1, Erk1/2, and CREB appear to be related to PKC signaling and PKC effect on drug sensitization since they were contra-regulated by HKPS when compared to dexamethasone-treated cells. Additionally, PKC inhibition by HKPS, but not by Enzastaurin, in MSC reduced the activity of three ABC transporters in leukemic cells treated with dexamethasone, a new indirect mechanism to increase sensitization to drug treatment in B-ALL cells. Our results show the validity of targeting the functional characteristic acquired and modulated during cell-to-cell interactions occurring in the leukemic niche." @default.
• W3198457875 created "2021-09-13" @default.
• W3198457875 creator A5038757989 @default.
• W3198457875 creator A5052639274 @default.
• W3198457875 creator A5074184324 @default.
• W3198457875 creator A5086188334 @default.
• W3198457875 date "2021-09-03" @default.
• W3198457875 modified "2023-10-18" @default.
• W3198457875 title "Sensitization to Drug Treatment in Precursor B-Cell Acute Lymphoblastic Leukemia Is Not Achieved by Stromal NF-κB Inhibition of Cell Adhesion but by Stromal PKC-Dependent Inhibition of ABC Transporters Activity" @default.
• W3198457875 cites W1507575667 @default.
• W3198457875 cites W1561620987 @default.
• W3198457875 cites W1569839307 @default.
• W3198457875 cites W1757444495 @default.
• W3198457875 cites W1967825122 @default.
• W3198457875 cites W1971436806 @default.
• W3198457875 cites W1978466041 @default.
• W3198457875 cites W1984072004 @default.
• W3198457875 cites W1984619334 @default.
• W3198457875 cites W1987446594 @default.
• W3198457875 cites W1992382947 @default.
• W3198457875 cites W1998973639 @default.
• W3198457875 cites W2009593167 @default.
• W3198457875 cites W2020622102 @default.
• W3198457875 cites W2021314764 @default.
• W3198457875 cites W2024968355 @default.
• W3198457875 cites W2025371271 @default.
• W3198457875 cites W2035749206 @default.
• W3198457875 cites W2043046186 @default.
• W3198457875 cites W2045722634 @default.
• W3198457875 cites W2051624063 @default.
• W3198457875 cites W2053737668 @default.
• W3198457875 cites W2056278417 @default.
• W3198457875 cites W2067064694 @default.
• W3198457875 cites W2069832306 @default.
• W3198457875 cites W2077132725 @default.
• W3198457875 cites W2094470615 @default.
• W3198457875 cites W2096358706 @default.
• W3198457875 cites W2106714479 @default.
• W3198457875 cites W2119374469 @default.
• W3198457875 cites W21272024 @default.
• W3198457875 cites W2148698340 @default.
• W3198457875 cites W2152711979 @default.
• W3198457875 cites W2163126426 @default.
• W3198457875 cites W2163555363 @default.
• W3198457875 cites W2291700481 @default.
• W3198457875 cites W2534765849 @default.
• W3198457875 cites W2544250865 @default.
• W3198457875 cites W2557535757 @default.
• W3198457875 cites W2742463119 @default.
• W3198457875 cites W2767444847 @default.
• W3198457875 cites W2931616080 @default.
• W3198457875 cites W2960758486 @default.
• W3198457875 cites W2976373753 @default.
• W3198457875 cites W2999646328 @default.
• W3198457875 cites W3007129510 @default.
• W3198457875 cites W3013890633 @default.
• W3198457875 cites W3027924039 @default.
• W3198457875 cites W3030558382 @default.
• W3198457875 cites W3095023411 @default.
• W3198457875 cites W3096331115 @default.
• W3198457875 cites W3159831149 @default.
• W3198457875 cites W4292528167 @default.
• W3198457875 cites W43972213 @default.
• W3198457875 doi "https://doi.org/10.3390/molecules26175366" @default.
• W3198457875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8433757" @default.
• W3198457875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34500796" @default.
• W3198457875 hasPublicationYear "2021" @default.
• W3198457875 type Work @default.
• W3198457875 sameAs 3198457875 @default.
• W3198457875 citedByCount "4" @default.
• W3198457875 countsByYear W31984578752022 @default.
• W3198457875 countsByYear W31984578752023 @default.
• W3198457875 crossrefType "journal-article" @default.
• W3198457875 hasAuthorship W3198457875A5038757989 @default.
• W3198457875 hasAuthorship W3198457875A5052639274 @default.
• W3198457875 hasAuthorship W3198457875A5074184324 @default.
• W3198457875 hasAuthorship W3198457875A5086188334 @default.
• W3198457875 hasBestOaLocation W31984578751 @default.
• W3198457875 hasConcept C16930146 @default.
• W3198457875 hasConcept C185592680 @default.
• W3198457875 hasConcept C195794163 @default.
• W3198457875 hasConcept C203014093 @default.
• W3198457875 hasConcept C2776217527 @default.
• W3198457875 hasConcept C502942594 @default.
• W3198457875 hasConcept C62478195 @default.
• W3198457875 hasConcept C75217442 @default.
• W3198457875 hasConcept C86803240 @default.
• W3198457875 hasConcept C95444343 @default.
• W3198457875 hasConcept C98274493 @default.
• W3198457875 hasConceptScore W3198457875C16930146 @default.
• W3198457875 hasConceptScore W3198457875C185592680 @default.
• W3198457875 hasConceptScore W3198457875C195794163 @default.
• W3198457875 hasConceptScore W3198457875C203014093 @default.
• W3198457875 hasConceptScore W3198457875C2776217527 @default.
• W3198457875 hasConceptScore W3198457875C502942594 @default.
• W3198457875 hasConceptScore W3198457875C62478195 @default.
• W3198457875 hasConceptScore W3198457875C75217442 @default.
• W3198457875 hasConceptScore W3198457875C86803240 @default.

• next