FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198472273> ?p ?o ?g. }

• W3198472273 abstract "Rapamycin-insensitive companion of mammalian target of rapamycin (Rictor) protein is a core subunit of mammalian target of rapamycin complex 2, and is associated with cancer progression. However, the biological function of Rictor in cancer, particularly its clinical relevance in gastric cancer (GC) remains largely unknown.Rictor expression and its association with clinicopathologic characteristics in GC were analyzed by immunohistochemistry. Effect of Rictor and Caveolin-1 (Cav 1) on GC cells apoptosis was evaluated via overexpression experiment in vitro. Mechanisms of Rictor and Cav 1 in GC were explored through overexpression and knockdown, by immunofluorescence and western blot analyses.Rictor was upregulated in GC, and mainly located in the cytoplasm of cancer cells. Moreover, higher Rictor levels were associated with worse prognosis. Rictor could inhibit GC cell apoptosis and promote cell growth in vitro. The results of immunofluorescence revealed that Cav 1 localized in GC cell membrane but did not co-localize with Rictor. Further, Rictor regulated apoptosis-related proteins, long non-coding RNAs and also activated cellular signaling, thereby positively regulating Cav 1 expression. This effect was attenuated by the Akt inhibitor ly294002. Cav 1 did not significantly affect the ability of Rictor to inhibit tumor cell apoptosis.Rictor is upregulated in GC and associated with worse prognosis. It inhibits tumor apoptosis and activates Cav 1 through the Akt signaling pathway to inhibit the apoptosis of GC cells. Rictor is, therefore, a promising prognostic biomarker and possible therapeutic target in GC patients." @default.
• W3198472273 created "2021-09-13" @default.
• W3198472273 creator A5008232261 @default.
• W3198472273 creator A5030218241 @default.
• W3198472273 creator A5041604554 @default.
• W3198472273 creator A5046979807 @default.
• W3198472273 creator A5065635383 @default.
• W3198472273 creator A5070214802 @default.
• W3198472273 creator A5071458554 @default.
• W3198472273 creator A5074131698 @default.
• W3198472273 creator A5083986563 @default.
• W3198472273 creator A5084471591 @default.
• W3198472273 creator A5087920969 @default.
• W3198472273 date "2021-09-01" @default.
• W3198472273 modified "2023-10-14" @default.
• W3198472273 title "Rictor Activates Cav 1 Through the Akt Signaling Pathway to Inhibit the Apoptosis of Gastric Cancer Cells" @default.
• W3198472273 cites W109346400 @default.
• W3198472273 cites W1531128472 @default.
• W3198472273 cites W1597188330 @default.
• W3198472273 cites W1825702768 @default.
• W3198472273 cites W1879644968 @default.
• W3198472273 cites W1974891484 @default.
• W3198472273 cites W1980402007 @default.
• W3198472273 cites W2002336642 @default.
• W3198472273 cites W2021578613 @default.
• W3198472273 cites W2034459992 @default.
• W3198472273 cites W2036691369 @default.
• W3198472273 cites W2051063623 @default.
• W3198472273 cites W2054073907 @default.
• W3198472273 cites W2057890879 @default.
• W3198472273 cites W2073251119 @default.
• W3198472273 cites W2074266971 @default.
• W3198472273 cites W2078382255 @default.
• W3198472273 cites W2104153516 @default.
• W3198472273 cites W2108029466 @default.
• W3198472273 cites W2126520642 @default.
• W3198472273 cites W2131196310 @default.
• W3198472273 cites W2131745475 @default.
• W3198472273 cites W2133475958 @default.
• W3198472273 cites W2144276265 @default.
• W3198472273 cites W2149701881 @default.
• W3198472273 cites W2152518226 @default.
• W3198472273 cites W2159391262 @default.
• W3198472273 cites W2169396440 @default.
• W3198472273 cites W2170671935 @default.
• W3198472273 cites W2175640013 @default.
• W3198472273 cites W2279047507 @default.
• W3198472273 cites W2294511660 @default.
• W3198472273 cites W2294733545 @default.
• W3198472273 cites W2342715069 @default.
• W3198472273 cites W2387313945 @default.
• W3198472273 cites W2464460497 @default.
• W3198472273 cites W2556213168 @default.
• W3198472273 cites W2560912840 @default.
• W3198472273 cites W2598137251 @default.
• W3198472273 cites W2606513998 @default.
• W3198472273 cites W2734421631 @default.
• W3198472273 cites W2767366610 @default.
• W3198472273 cites W2768273324 @default.
• W3198472273 cites W2778885300 @default.
• W3198472273 cites W2873604606 @default.
• W3198472273 cites W2886974284 @default.
• W3198472273 cites W2889646458 @default.
• W3198472273 cites W2898820339 @default.
• W3198472273 cites W2900509630 @default.
• W3198472273 cites W2901242178 @default.
• W3198472273 cites W2969086321 @default.
• W3198472273 cites W2972112165 @default.
• W3198472273 cites W2991002790 @default.
• W3198472273 cites W3010638295 @default.
• W3198472273 cites W3033366394 @default.
• W3198472273 cites W3041020241 @default.
• W3198472273 cites W3080648871 @default.
• W3198472273 cites W766698460 @default.
• W3198472273 doi "https://doi.org/10.3389/fonc.2021.641453" @default.
• W3198472273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8442624" @default.
• W3198472273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34540654" @default.
• W3198472273 hasPublicationYear "2021" @default.
• W3198472273 type Work @default.
• W3198472273 sameAs 3198472273 @default.
• W3198472273 citedByCount "2" @default.
• W3198472273 countsByYear W31984722732021 @default.
• W3198472273 countsByYear W31984722732022 @default.
• W3198472273 crossrefType "journal-article" @default.
• W3198472273 hasAuthorship W3198472273A5008232261 @default.
• W3198472273 hasAuthorship W3198472273A5030218241 @default.
• W3198472273 hasAuthorship W3198472273A5041604554 @default.
• W3198472273 hasAuthorship W3198472273A5046979807 @default.
• W3198472273 hasAuthorship W3198472273A5065635383 @default.
• W3198472273 hasAuthorship W3198472273A5070214802 @default.
• W3198472273 hasAuthorship W3198472273A5071458554 @default.
• W3198472273 hasAuthorship W3198472273A5074131698 @default.
• W3198472273 hasAuthorship W3198472273A5083986563 @default.
• W3198472273 hasAuthorship W3198472273A5084471591 @default.
• W3198472273 hasAuthorship W3198472273A5087920969 @default.
• W3198472273 hasBestOaLocation W31984722731 @default.
• W3198472273 hasConcept C104317684 @default.
• W3198472273 hasConcept C121608353 @default.
• W3198472273 hasConcept C127561419 @default.
• W3198472273 hasConcept C173396325 @default.

• next