Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198519076> ?p ?o ?g. }
- W3198519076 abstract "Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in different animal models. However, its effects and mechanisms on AS have not been clearly defined. We determined whether HLJDD attenuated atherosclerosis and plaques vulnerability by regulating macrophage polarization in ApoE −/− mice induced by high-fat diet (HFD). Furthermore, we investigated the effects of HLJDD on macrophage polarization in oxidized low-density lipoprotein (ox-LDL) induced RAW264.7 cells. For in vivo assay, compared with the model group, HLJDD ameliorated lipid metabolism, with significantly decreased levels of serum triglyceride, total cholesterol (CHOL), and lipid density lipoprotein. HLJDD suppressed serum tumor necrosis factor α (TNF-α) and IL-1β levels with increased serum IL-10 level, and inhibited mRNA level of NLRP3 inflammasome in carotid tissues. HLJDD enhanced carotid lesion stability by decreasing macrophage infiltration together with increased expression of collagen fibers and α-SMA. Moreover, HLJDD inhibited M1 macrophage polarization, which decreased the expression and mRNA levels of M1 markers [inducible nitric oxide synthase (iNOS) and CD86]. HLJDD enhanced alternatively activated macrophage (M2) activation, which increased the expression and mRNA levels of M2 markers (Arg-1 and CD163). For in vitro assay, HLJDD inhibited foam cell formation in RAW264.7 macrophages disturbed by ox-LDL. Besides, groups with ox-LDL plus HLJDD drug had a lower expression of CD86 and mRNA levels of iNOS, CD86, and IL-1β, but higher expression of CD163 and mRNA levels of Arg-1, CD163, and IL-10 than ox-LDL group. Collectively, our results revealed that HLJDD alleviated atherosclerosis and promoted plaque stability by suppressing M1 polarization and enhancing M2 polarization." @default.
- W3198519076 created "2021-09-13" @default.
- W3198519076 creator A5020906285 @default.
- W3198519076 creator A5031121295 @default.
- W3198519076 creator A5034637638 @default.
- W3198519076 creator A5035312472 @default.
- W3198519076 creator A5042275051 @default.
- W3198519076 creator A5044888290 @default.
- W3198519076 creator A5055987305 @default.
- W3198519076 creator A5056600434 @default.
- W3198519076 creator A5070147304 @default.
- W3198519076 creator A5070931760 @default.
- W3198519076 creator A5074014514 @default.
- W3198519076 creator A5081294272 @default.
- W3198519076 date "2021-09-02" @default.
- W3198519076 modified "2023-10-16" @default.
- W3198519076 title "Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization" @default.
- W3198519076 cites W1561041814 @default.
- W3198519076 cites W1972483153 @default.
- W3198519076 cites W1985554823 @default.
- W3198519076 cites W2005847833 @default.
- W3198519076 cites W2008960002 @default.
- W3198519076 cites W2019221616 @default.
- W3198519076 cites W2023258182 @default.
- W3198519076 cites W2054472394 @default.
- W3198519076 cites W2070855360 @default.
- W3198519076 cites W2074954748 @default.
- W3198519076 cites W2079724669 @default.
- W3198519076 cites W2087726524 @default.
- W3198519076 cites W2100748836 @default.
- W3198519076 cites W2112360098 @default.
- W3198519076 cites W2121175872 @default.
- W3198519076 cites W2125951189 @default.
- W3198519076 cites W2129231503 @default.
- W3198519076 cites W2129909114 @default.
- W3198519076 cites W2135272175 @default.
- W3198519076 cites W2170320714 @default.
- W3198519076 cites W2176878760 @default.
- W3198519076 cites W2206508642 @default.
- W3198519076 cites W2274924551 @default.
- W3198519076 cites W2295230703 @default.
- W3198519076 cites W2324841714 @default.
- W3198519076 cites W2497350880 @default.
- W3198519076 cites W2507299093 @default.
- W3198519076 cites W2519634482 @default.
- W3198519076 cites W2525459565 @default.
- W3198519076 cites W2601625032 @default.
- W3198519076 cites W2606115157 @default.
- W3198519076 cites W2638811768 @default.
- W3198519076 cites W2730540036 @default.
- W3198519076 cites W2751811589 @default.
- W3198519076 cites W2770717271 @default.
- W3198519076 cites W2772108018 @default.
- W3198519076 cites W2781670419 @default.
- W3198519076 cites W2782685575 @default.
- W3198519076 cites W2799714554 @default.
- W3198519076 cites W2804609215 @default.
- W3198519076 cites W2896119560 @default.
- W3198519076 cites W2902530564 @default.
- W3198519076 cites W2908018414 @default.
- W3198519076 cites W2909765747 @default.
- W3198519076 cites W2920248606 @default.
- W3198519076 cites W2946521848 @default.
- W3198519076 cites W2964068120 @default.
- W3198519076 cites W2969263951 @default.
- W3198519076 cites W2980164719 @default.
- W3198519076 cites W2980636895 @default.
- W3198519076 cites W2988988674 @default.
- W3198519076 cites W2990528901 @default.
- W3198519076 cites W2996350724 @default.
- W3198519076 cites W3008486450 @default.
- W3198519076 cites W3010858550 @default.
- W3198519076 cites W3017260536 @default.
- W3198519076 cites W3032927084 @default.
- W3198519076 cites W3037676992 @default.
- W3198519076 cites W3109990765 @default.
- W3198519076 cites W4205186352 @default.
- W3198519076 cites W4211134725 @default.
- W3198519076 cites W2001030826 @default.
- W3198519076 doi "https://doi.org/10.3389/fphys.2021.666449" @default.
- W3198519076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445160" @default.
- W3198519076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34539422" @default.
- W3198519076 hasPublicationYear "2021" @default.
- W3198519076 type Work @default.
- W3198519076 sameAs 3198519076 @default.
- W3198519076 citedByCount "14" @default.
- W3198519076 countsByYear W31985190762021 @default.
- W3198519076 countsByYear W31985190762022 @default.
- W3198519076 countsByYear W31985190762023 @default.
- W3198519076 crossrefType "journal-article" @default.
- W3198519076 hasAuthorship W3198519076A5020906285 @default.
- W3198519076 hasAuthorship W3198519076A5031121295 @default.
- W3198519076 hasAuthorship W3198519076A5034637638 @default.
- W3198519076 hasAuthorship W3198519076A5035312472 @default.
- W3198519076 hasAuthorship W3198519076A5042275051 @default.
- W3198519076 hasAuthorship W3198519076A5044888290 @default.
- W3198519076 hasAuthorship W3198519076A5055987305 @default.
- W3198519076 hasAuthorship W3198519076A5056600434 @default.
- W3198519076 hasAuthorship W3198519076A5070147304 @default.
- W3198519076 hasAuthorship W3198519076A5070931760 @default.