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- W3198537210 abstract "<h3>Background</h3> Curcumin has been claimed to have gastrointestinal benefits including dyspepsia—a common disorder that could be managed in a primary care setting with behavioral and dietary modification as well as over-the-counter medications. This study aimed to compare the efficacy of curcumin versus omeprazole in improving patient-reported outcomes. <h3>Methods</h3> This randomized controlled trial comprised of three arms of four large (250 mg of curcumin or placebo) and one small (20 mg of omeprazole or placebo) capsules: curcumin only (C), omeprazole only (O), and curcumin+omeprazole (C+O). The large capsules were taken four times daily and the small capsules were taken twice daily for 28 days. Eligible participants with dyspepsia symptoms, assessed by using the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), underwent gastroscopy by certified gastroenterologists; those with pathologic dyspepsia including Helicobacter pylori infection were excluded. Functional dyspepsia symptoms were assessed by using the Severity of Dyspepsia Assessment (SODA) scores at baseline, day 28, and day 56. Demographics and clinical characteristics were analyzed by using descriptive statistics. Comparative improvement of SODA scores across the three arms, adjusted for potential confounders, were analyzed by using generalized estimating equations (GEE) regression. <h3>Results</h3> A total of 207 participants; C (69), O (69), C+O (69), were recruited, of which 151; C (49), O (49), C+O (53) completed the study. The overall mean age was 49.7±11.9 years and 73.4% were female. Demographics, clinical characteristics, baseline SODA, and SF-LDQ scores were comparable across the three groups. The SODA pain intensity reduction (C: -6.22 and -9.59; O: -6.98 and -10.62; C+O: -5.41 and -8.23) and SODA non-pain symptoms improvement (C: -2.45 and -4.77; O: -2.55 and -4.59; C+O: -2.41 and -4.65) were not significantly different across the three groups at day 28 (p=0.491 and 0.964) and 56 (p=0.259 and 0.462), respectively. No serious adverse events were observed. <h3>Conclusions</h3> Curcumin and omeprazole have comparable efficacy for functional dyspepsia with no obvious synergistic effect." @default.
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- W3198537210 date "2021-09-01" @default.
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- W3198537210 title "IDDF2021-ABS-0044 Comparable efficacy of curcumin and proton pump inhibitor for functional dyspepsia: a randomized double-blinded controlled trial" @default.
- W3198537210 doi "https://doi.org/10.1136/gutjnl-2021-iddf.117" @default.
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