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- W3198537296 abstract "As resident immune cells of the brain, microglia serve pivotal roles in regulating neuronal function under both physiological and pathological conditions, including aging and the most prevalent neurodegenerative disease, Alzheimer’s disease (AD). Instructed by neurons, microglia regulate synaptic function and guard brain homeostasis throughout life. Dysregulation of microglial function, however, can lead to dire consequences, including aggravated cognitive decline during aging and exacerbated neuropathology in diseases. The triggering receptor expressed on myeloid cells 2 (TREM2) is a key regulator of microglial function. Loss-of-function variants of TREM2 are associated with an increased risk of AD. TREM2 orchestrates the switch of microglial transcriptome programming that modulates microglial chemotaxis, phagocytosis, and inflammatory responses, as well as microglial regulation of synaptic function in health and disease. Intriguingly, the outcome of microglial/TREM2 function is influenced by age and the context of neuropathology. This review summarizes the rapidly growing research on TREM2 under physiological conditions and in AD, particularly highlighting the impact of TREM2 on neuronal function." @default.
- W3198537296 created "2021-09-13" @default.
- W3198537296 creator A5056329233 @default.
- W3198537296 creator A5056866818 @default.
- W3198537296 date "2021-09-02" @default.
- W3198537296 modified "2023-09-23" @default.
- W3198537296 title "Microglial TREM2 at the Intersection of Brain Aging and Alzheimer’s Disease" @default.
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- W3198537296 doi "https://doi.org/10.1177/10738584211040786" @default.
- W3198537296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34470515" @default.
- W3198537296 hasPublicationYear "2021" @default.
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