Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198569570> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3198569570 endingPage "129" @default.
- W3198569570 startingPage "124" @default.
- W3198569570 abstract "This exposition reveals the effect of glucose as a molecular crowder on the solvent environment in proximity of the protein surface in putative folded (Ubiquitin) and intrinsically disordered (dimeric Amyloid beta) states. Atomistic simulations reveal markedly higher structural perturbation in the disordered systems due to crowding effects, while the folded state retains overall structural fidelity. Key hydrophobic contacts in the disordered dimer are lost. However, glucose induced crowding results in elevated hydration on surfaces of both protein systems. Despite evident differences in their structural responses, the hydration layer of both the folded and disordered states display a distinct enhancement in lifetimes of mean residence and rotational relaxation under the hyperglycemic conditions. The results are crucial in the light of emergent co-solvent induced biological phenomena in crowded media." @default.
- W3198569570 created "2021-09-13" @default.
- W3198569570 creator A5023659460 @default.
- W3198569570 creator A5051855555 @default.
- W3198569570 date "2021-11-01" @default.
- W3198569570 modified "2023-10-16" @default.
- W3198569570 title "The protein hydration layer in high glucose concentration: Dynamical responses in folded and intrinsically disordered dimeric states" @default.
- W3198569570 cites W1968472876 @default.
- W3198569570 cites W1970948529 @default.
- W3198569570 cites W1976499671 @default.
- W3198569570 cites W2005509806 @default.
- W3198569570 cites W2015517515 @default.
- W3198569570 cites W2029667189 @default.
- W3198569570 cites W2038559728 @default.
- W3198569570 cites W2046847750 @default.
- W3198569570 cites W2056544504 @default.
- W3198569570 cites W2058241222 @default.
- W3198569570 cites W2059183767 @default.
- W3198569570 cites W2106638887 @default.
- W3198569570 cites W2131736580 @default.
- W3198569570 cites W2144062946 @default.
- W3198569570 cites W2150766477 @default.
- W3198569570 cites W2156012420 @default.
- W3198569570 cites W2226243838 @default.
- W3198569570 cites W2281295135 @default.
- W3198569570 cites W2614679217 @default.
- W3198569570 cites W2794654572 @default.
- W3198569570 cites W2962727823 @default.
- W3198569570 doi "https://doi.org/10.1016/j.bbrc.2021.09.005" @default.
- W3198569570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34509724" @default.
- W3198569570 hasPublicationYear "2021" @default.
- W3198569570 type Work @default.
- W3198569570 sameAs 3198569570 @default.
- W3198569570 citedByCount "2" @default.
- W3198569570 countsByYear W31985695702022 @default.
- W3198569570 crossrefType "journal-article" @default.
- W3198569570 hasAuthorship W3198569570A5023659460 @default.
- W3198569570 hasAuthorship W3198569570A5051855555 @default.
- W3198569570 hasConcept C12554922 @default.
- W3198569570 hasConcept C147597530 @default.
- W3198569570 hasConcept C159467904 @default.
- W3198569570 hasConcept C169760540 @default.
- W3198569570 hasConcept C178790620 @default.
- W3198569570 hasConcept C185592680 @default.
- W3198569570 hasConcept C2776029896 @default.
- W3198569570 hasConcept C2778815515 @default.
- W3198569570 hasConcept C2779546866 @default.
- W3198569570 hasConcept C55493867 @default.
- W3198569570 hasConcept C59593255 @default.
- W3198569570 hasConcept C8010536 @default.
- W3198569570 hasConcept C86803240 @default.
- W3198569570 hasConceptScore W3198569570C12554922 @default.
- W3198569570 hasConceptScore W3198569570C147597530 @default.
- W3198569570 hasConceptScore W3198569570C159467904 @default.
- W3198569570 hasConceptScore W3198569570C169760540 @default.
- W3198569570 hasConceptScore W3198569570C178790620 @default.
- W3198569570 hasConceptScore W3198569570C185592680 @default.
- W3198569570 hasConceptScore W3198569570C2776029896 @default.
- W3198569570 hasConceptScore W3198569570C2778815515 @default.
- W3198569570 hasConceptScore W3198569570C2779546866 @default.
- W3198569570 hasConceptScore W3198569570C55493867 @default.
- W3198569570 hasConceptScore W3198569570C59593255 @default.
- W3198569570 hasConceptScore W3198569570C8010536 @default.
- W3198569570 hasConceptScore W3198569570C86803240 @default.
- W3198569570 hasFunder F4320320767 @default.
- W3198569570 hasFunder F4320321019 @default.
- W3198569570 hasFunder F4320334771 @default.
- W3198569570 hasLocation W31985695701 @default.
- W3198569570 hasOpenAccess W3198569570 @default.
- W3198569570 hasPrimaryLocation W31985695701 @default.
- W3198569570 hasRelatedWork W1989619262 @default.
- W3198569570 hasRelatedWork W2011173220 @default.
- W3198569570 hasRelatedWork W2016412885 @default.
- W3198569570 hasRelatedWork W2030272068 @default.
- W3198569570 hasRelatedWork W2069972120 @default.
- W3198569570 hasRelatedWork W2074344647 @default.
- W3198569570 hasRelatedWork W2431276398 @default.
- W3198569570 hasRelatedWork W2977558829 @default.
- W3198569570 hasRelatedWork W3089212823 @default.
- W3198569570 hasRelatedWork W4237118483 @default.
- W3198569570 hasVolume "577" @default.
- W3198569570 isParatext "false" @default.
- W3198569570 isRetracted "false" @default.
- W3198569570 magId "3198569570" @default.
- W3198569570 workType "article" @default.