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• W3198588764 abstract "Abstract Iron is essential to living cells, acting as a cofactor in a number of essential enzymes in metabolism; however, iron requires proper storage or it can be dangerous to the cell. In both yeast and plants, iron is stored in a vacuole through the action of a vacuolar iron transporter (VIT). This transporter is conserved in the apicomplexan family of obligate intracellular parasites, including in Toxoplasma gondii , a pathogen of medical and veterinary importance. Here, we assess the role of VIT in T. gondii . We show that deletion of VIT causes a slight growth defect in vitro , however leads to hypersensitivity in the presence of excess iron, confirming its essential role in iron detoxification in the parasite. In the absence of VIT, parasites contain less iron and are at a growth disadvantage when moving into an iron-depleted environment. We show parasite VIT expression is regulated by environmental iron levels at both the transcript and protein level, and by altering the distribution of VIT within the cell. In the absence of VIT, we find that the T. gondii responds by altering expression of genes with a role in iron metabolism and by increasing the activity of the antioxidant protein catalase. We also show that iron detoxification has an important role both in parasite survival within macrophages and in pathogenesis in a mouse model. Together, by demonstrating a critical role for VIT during iron detoxification in T. gondii , we reveal the importance of iron storage in the parasite and provide the first insight into the machinery involved." @default.
• W3198588764 created "2021-09-13" @default.
• W3198588764 creator A5004692201 @default.
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• W3198588764 creator A5077758356 @default.
• W3198588764 date "2021-09-09" @default.
• W3198588764 modified "2023-10-01" @default.
• W3198588764 title "The vacuolar iron transporter mediates iron detoxification in<i>Toxoplasma gondii</i>" @default.
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• W3198588764 doi "https://doi.org/10.1101/2021.09.08.458725" @default.
• W3198588764 hasPublicationYear "2021" @default.
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