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- W319860110 abstract "The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of bromotrifluoromethane`s (Halon 1301) proposed replacement chemicals HFC-227ea, HFC-125, and FC-218. Parallel information pertaining to Halon 1301 and CF(3)I can be found in AL/OE-TR-1994-0068. Tissue to air partition coefficients were determined using the vial equilibration method. Inhalation pharmacokinetics for all Halon 1301 replacements were determined experimentally in Fischer 344 (F-344) male rats via a closed chamber recirculating gas uptake methods. A physiologically-based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these experiments." @default.
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- W319860110 date "1995-02-01" @default.
- W319860110 modified "2023-09-27" @default.
- W319860110 title "Inhalation uptake and metabolism of Halon 1301 replacement candidates, HFC-227ea, HFC-125, and FC-218. Interim report, March-December 1994" @default.
- W319860110 hasPublicationYear "1995" @default.
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