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- W3198603973 abstract "The osteoinductivity of bioactive glass ceramics (BGCs) is dependent on their ability to effectively interact with the surrounding physiological environment and influence the fate of target cells; however, masking and poor dispersion can negatively influence bioactivity. Here, we address this problem via a simple fabrication method of assembling highly ordered and aligned arrays of BGC nanoneedle-like structures (@) on the outer surface of various polyamide 6 (PA6) substrates (casted film, 3D printing filaments, electrospun fibre mats) by ion dissociation. The staggered-like nanoneedles of [email protected] substrates with excellent uniform dispersion showed favourable cell viability, proliferation, and spreading of MC3T3 osteoblast-like cells. Moreover, the immobilized BGC nanoneedles induced osteogenic differentiation and accelerated the expression of late osteoblast marker genes, compared to the control group. Furthermore, the [email protected] composite showed high affinity for bone-like apatite formation when incubated in physiological body fluids. These findings suggest that the unique dispersion of [email protected] substrates with nanostructure features make them attractive candidates for bone tissue regeneration and open avenues for future investigation into exploiting these properties for bone tissue engineering. Importantly, this work provides a novel concept for in-situ immobilization of BGC with distinctive topographical features onto polymer substrates simulating natural bone structure." @default.
- W3198603973 created "2021-09-13" @default.
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- W3198603973 date "2021-11-01" @default.
- W3198603973 modified "2023-10-18" @default.
- W3198603973 title "Immobilization of bioactive glass ceramics @ 2D and 3D polyamide polymer substrates for bone tissue regeneration" @default.
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- W3198603973 doi "https://doi.org/10.1016/j.matdes.2021.110094" @default.
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