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• W3198608848 abstract "Abstract Background Cystic echinococcosis (CE), is a parasitic zoonosis caused by Echinococcus granulosus ( E. granulosus ) larvae in liver and lungs of both humans and animals. Surgical intervention is the mainstay for CE treatment, using scolicidal agents that inactivate live protoscolices. This study evaluated the scolicidal effects of Silybum marianum ethanolic extract and its combination with albendazole in vitro for the first time. Moreover, in a literature review, we investigated the effects of a wide range of Iranian medicinal plants on protoscolices of E. granulosus . Methods S. marianum ethanolic extract was prepared and high-performance liquid chromatography (HPLC) analysis was used to establish the proportions of its component compounds in the extract. Cytotoxicity was evaluated in mouse macrophage cells (J774A.1 cell line) using MTT method. Next, the scolicidal activity of the extract alone and combined with albendazole was tested as triplicate at various concentrations incubated for 5, 10, 20, 30, and 60 min. Finally, protoscolex viability was determined using 0.1% eosin as a vital stain. PCR–RFLP and DNA sequencing techniques were used to characterize the genotype of E. granulosus . Results HPLC analysis showed that S. marianum ethanolic extract contained mostly silydianin (14.41%), isosilybin A (10.50%), and silychristin (10.46%). The greatest scolicidal effects were obtained with the combination of S. marianum with albendazole (79%), S. marianum ethanolic extract alone (77%) and albendazole (69%), at a concentration of 500 μg/ml for 60 min, respectively ( P < 0.05). Molecular analysis showed that all the cysts used were G1 genotype. Conclusion The data suggest that S. marianum ethanolic extract is a potential scolicide in vitro; however, further investigations are required to determine its efficacy in vivo." @default.
• W3198608848 created "2021-09-13" @default.
• W3198608848 creator A5006720918 @default.
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• W3198608848 date "2021-09-08" @default.
• W3198608848 modified "2023-09-25" @default.
• W3198608848 title "Silybum marianum ethanolic extract: in vitro effects on protoscolices of Echinococcus granulosus G1 strain with emphasis on other Iranian medicinal plants" @default.
• W3198608848 cites W1877687377 @default.
• W3198608848 cites W1969560715 @default.
• W3198608848 cites W1975101958 @default.
• W3198608848 cites W1976437035 @default.
• W3198608848 cites W1989723829 @default.
• W3198608848 cites W1992525213 @default.
• W3198608848 cites W1994553434 @default.
• W3198608848 cites W1995656733 @default.
• W3198608848 cites W2004317356 @default.
• W3198608848 cites W2009175005 @default.
• W3198608848 cites W2013287347 @default.
• W3198608848 cites W2018597228 @default.
• W3198608848 cites W2018986886 @default.
• W3198608848 cites W2021112085 @default.
• W3198608848 cites W2028076218 @default.
• W3198608848 cites W2036569753 @default.
• W3198608848 cites W2049071602 @default.
• W3198608848 cites W2051780232 @default.
• W3198608848 cites W2054752311 @default.
• W3198608848 cites W2058603720 @default.
• W3198608848 cites W2059369832 @default.
• W3198608848 cites W2068012967 @default.
• W3198608848 cites W2069978879 @default.
• W3198608848 cites W2070492234 @default.
• W3198608848 cites W2083163161 @default.
• W3198608848 cites W2086594204 @default.
• W3198608848 cites W2089171864 @default.
• W3198608848 cites W2089718798 @default.
• W3198608848 cites W2090313808 @default.
• W3198608848 cites W2091366287 @default.
• W3198608848 cites W2092053724 @default.
• W3198608848 cites W2104993988 @default.
• W3198608848 cites W2114398355 @default.
• W3198608848 cites W2115023745 @default.
• W3198608848 cites W2115547348 @default.
• W3198608848 cites W2128109107 @default.
• W3198608848 cites W2129719828 @default.
• W3198608848 cites W2137246755 @default.
• W3198608848 cites W2139988692 @default.
• W3198608848 cites W2143501409 @default.
• W3198608848 cites W2144005942 @default.
• W3198608848 cites W2148582246 @default.
• W3198608848 cites W2149697993 @default.
• W3198608848 cites W2155458365 @default.
• W3198608848 cites W2157335302 @default.
• W3198608848 cites W2161188519 @default.
• W3198608848 cites W2166498541 @default.
• W3198608848 cites W2170278429 @default.
• W3198608848 cites W2188611891 @default.
• W3198608848 cites W2233278067 @default.
• W3198608848 cites W2255910620 @default.
• W3198608848 cites W2300365986 @default.
• W3198608848 cites W2305968810 @default.
• W3198608848 cites W2323160168 @default.
• W3198608848 cites W2414419931 @default.
• W3198608848 cites W2521305553 @default.
• W3198608848 cites W2605724112 @default.
• W3198608848 cites W2621784409 @default.
• W3198608848 cites W2708801362 @default.
• W3198608848 cites W2740437605 @default.
• W3198608848 cites W2740445094 @default.
• W3198608848 cites W2792871080 @default.
• W3198608848 cites W2795785744 @default.
• W3198608848 cites W2803396788 @default.
• W3198608848 cites W2889388148 @default.
• W3198608848 cites W2898750338 @default.
• W3198608848 cites W2910175538 @default.
• W3198608848 cites W2913600262 @default.
• W3198608848 cites W2921350380 @default.
• W3198608848 cites W2942591634 @default.
• W3198608848 cites W2960698773 @default.
• W3198608848 cites W2973727343 @default.
• W3198608848 cites W2995604045 @default.
• W3198608848 cites W3001547758 @default.
• W3198608848 cites W3009836981 @default.
• W3198608848 cites W3021816309 @default.
• W3198608848 cites W3094532196 @default.
• W3198608848 cites W3159945902 @default.
• W3198608848 cites W4233522674 @default.
• W3198608848 cites W4234373079 @default.
• W3198608848 cites W58646481 @default.
• W3198608848 doi "https://doi.org/10.1186/s41182-021-00363-7" @default.
• W3198608848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8424884" @default.
• W3198608848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34496975" @default.
• W3198608848 hasPublicationYear "2021" @default.
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