FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198624164> ?p ?o ?g. }

• W3198624164 endingPage "300" @default.
• W3198624164 startingPage "291" @default.
• W3198624164 abstract "Due to the antioxidant properties of lignin, it has been demonstrated as an active substance for treating oxidation-related and inflammatory diseases. However, how the structural properties of lignin affect its biological activities is still ambiguous. In this study, Kraft lignin from wheat straw (KL-A) was used as the raw material to fractionate into three fractions ( e.g. , KL-B, KL-C, and KL-D) with different molecular weight by ultrafiltration, which possessed different physicochemical properties. The biocompatibility, in vivo and in vitro scavenging abilities for reactive oxygen species (ROS), and anti-apoptotic abilities of the lignin fractions were evaluated using SW1353 chondrocyte cell lines and were quantitatively fitted to their physicochemical properties. The results showed that lignin fractions with lower molecular weights, lower G/S ratios, and higher non-condensed phenolic OH contents endowed lignin with stronger ROS scavenging ability in vivo and in vitro , but was accompanied by increased cytotoxicity to cells. The half maximal inhibitory concentration (IC50) of KL-A, KL-B, KL-C, and KL-D were separately determined as 44.02, 33.43, 32.41, and 18.40 μg/mL. Furthermore, KL-D, with the lowest molecular weight and highest number of functional groups, showed the best antioxidant ability, while it performed poorly in inhibiting cellular apoptosis of chondrocytes. Compared to KL-D, KL-C with inverse structural properties, performed better in anti-apoptosis of SW1353 cells, which is the optimum lignin as promising active substances to be applied in the treatment of osteoarthritis in biomedical engineering." @default.
• W3198624164 created "2021-09-13" @default.
• W3198624164 creator A5007115893 @default.
• W3198624164 creator A5047441192 @default.
• W3198624164 creator A5048461976 @default.
• W3198624164 creator A5049981926 @default.
• W3198624164 creator A5069789561 @default.
• W3198624164 creator A5071798264 @default.
• W3198624164 creator A5078018786 @default.
• W3198624164 creator A5080241509 @default.
• W3198624164 date "2021-11-01" @default.
• W3198624164 modified "2023-10-16" @default.
• W3198624164 title "Understanding the relationship between the structural properties of lignin and their biological activities" @default.
• W3198624164 cites W1967750966 @default.
• W3198624164 cites W2012713928 @default.
• W3198624164 cites W2067017156 @default.
• W3198624164 cites W2082564222 @default.
• W3198624164 cites W2124765964 @default.
• W3198624164 cites W2167988682 @default.
• W3198624164 cites W2225017464 @default.
• W3198624164 cites W2230648594 @default.
• W3198624164 cites W2296387009 @default.
• W3198624164 cites W2303694963 @default.
• W3198624164 cites W2323564946 @default.
• W3198624164 cites W2550899617 @default.
• W3198624164 cites W2561612185 @default.
• W3198624164 cites W2621875876 @default.
• W3198624164 cites W2757048139 @default.
• W3198624164 cites W2766348128 @default.
• W3198624164 cites W2784208369 @default.
• W3198624164 cites W2808688129 @default.
• W3198624164 cites W2912116772 @default.
• W3198624164 cites W2938137135 @default.
• W3198624164 cites W2945558983 @default.
• W3198624164 cites W2951145023 @default.
• W3198624164 cites W2963701844 @default.
• W3198624164 cites W2972347225 @default.
• W3198624164 cites W2988318375 @default.
• W3198624164 cites W2989655268 @default.
• W3198624164 cites W2996761400 @default.
• W3198624164 cites W3014613793 @default.
• W3198624164 cites W3031059230 @default.
• W3198624164 cites W3035850494 @default.
• W3198624164 cites W3085354460 @default.
• W3198624164 cites W3087905019 @default.
• W3198624164 cites W3121947712 @default.
• W3198624164 cites W3164179484 @default.
• W3198624164 cites W4248078302 @default.
• W3198624164 doi "https://doi.org/10.1016/j.ijbiomac.2021.08.168" @default.
• W3198624164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34461157" @default.
• W3198624164 hasPublicationYear "2021" @default.
• W3198624164 type Work @default.
• W3198624164 sameAs 3198624164 @default.
• W3198624164 citedByCount "45" @default.
• W3198624164 countsByYear W31986241642021 @default.
• W3198624164 countsByYear W31986241642022 @default.
• W3198624164 countsByYear W31986241642023 @default.
• W3198624164 crossrefType "journal-article" @default.
• W3198624164 hasAuthorship W3198624164A5007115893 @default.
• W3198624164 hasAuthorship W3198624164A5047441192 @default.
• W3198624164 hasAuthorship W3198624164A5048461976 @default.
• W3198624164 hasAuthorship W3198624164A5049981926 @default.
• W3198624164 hasAuthorship W3198624164A5069789561 @default.
• W3198624164 hasAuthorship W3198624164A5071798264 @default.
• W3198624164 hasAuthorship W3198624164A5078018786 @default.
• W3198624164 hasAuthorship W3198624164A5080241509 @default.
• W3198624164 hasConcept C109316439 @default.
• W3198624164 hasConcept C150903083 @default.
• W3198624164 hasConcept C178790620 @default.
• W3198624164 hasConcept C181199279 @default.
• W3198624164 hasConcept C185592680 @default.
• W3198624164 hasConcept C190283241 @default.
• W3198624164 hasConcept C202751555 @default.
• W3198624164 hasConcept C207001950 @default.
• W3198624164 hasConcept C2778004101 @default.
• W3198624164 hasConcept C2781052789 @default.
• W3198624164 hasConcept C2781403057 @default.
• W3198624164 hasConcept C31903555 @default.
• W3198624164 hasConcept C48349386 @default.
• W3198624164 hasConcept C50817676 @default.
• W3198624164 hasConcept C55493867 @default.
• W3198624164 hasConcept C58121356 @default.
• W3198624164 hasConcept C86803240 @default.
• W3198624164 hasConceptScore W3198624164C109316439 @default.
• W3198624164 hasConceptScore W3198624164C150903083 @default.
• W3198624164 hasConceptScore W3198624164C178790620 @default.
• W3198624164 hasConceptScore W3198624164C181199279 @default.
• W3198624164 hasConceptScore W3198624164C185592680 @default.
• W3198624164 hasConceptScore W3198624164C190283241 @default.
• W3198624164 hasConceptScore W3198624164C202751555 @default.
• W3198624164 hasConceptScore W3198624164C207001950 @default.
• W3198624164 hasConceptScore W3198624164C2778004101 @default.
• W3198624164 hasConceptScore W3198624164C2781052789 @default.
• W3198624164 hasConceptScore W3198624164C2781403057 @default.
• W3198624164 hasConceptScore W3198624164C31903555 @default.
• W3198624164 hasConceptScore W3198624164C48349386 @default.
• W3198624164 hasConceptScore W3198624164C50817676 @default.
• W3198624164 hasConceptScore W3198624164C55493867 @default.

• next