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• W3198625084 abstract "Abstract The activation of α7 nicotinic acetylcholine receptors (nAChRs) has been shown to improve hippocampus‐dependent learning and memory. α7 nAChRs are densely expressed among several different cell types in the hippocampus, with high Ca 2+ permeability, although it is unclear if α7 nAChRs mobilize differential signalling mechanisms among distinct neuronal populations. To address this question, we compared α7 nAChR agonist‐induced responses (i.e. calcium and cAMP changes) between granule cells and GABAergic neurons in the hippocampal dentate gyrus both in vitro and in vivo . In cultured organotypic hippocampal slices, we observed robust intracellular calcium and cAMP increases in dentate granule cells upon activation of α7 nAChRs. In contrast, GABAergic interneurons displayed little change in either calcium or cAMP concentration after α7 nAChR activation, even though they displayed much larger α7 nAChR current responses than those of dentate granule cells. We found that this was due to smaller α7 nAChR‐induced Ca 2+ rises in GABAergic interneurons. Thus, the regulation of the Ca 2+ transients in different cell types resulted in differential subsequent intracellular signalling cascades and likely the ultimate outcome of α7 nAChR activation. Furthermore, we monitored neuronal activities of dentate granule cells and GABAergic interneurons in vivo via optic fibre photometry. We observed enhancement of neuronal activities after nicotine administration in dentate granule cells, but not in GABAergic neurons, which was absent in α7 nAChR‐deficient granule cells. In summary, we reveal a mechanism for α7 nAChR‐mediated increase of neuronal activity via cell type‐specific intracellular signalling pathways. image Key points α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and regulate a variety of brain functions including learning and memory. Understanding the cellular signalling mechanisms of their activations among different neuronal populations is important for delineating their actions in cognitive function, and developing effective treatment strategies for cognitive deficits. We report that α7 nAChR activation leads to Ca 2+ and cAMP increases in granule cells (but not in GABAergic interneurons) in hippocampal dentate gyrus in vitro , a key region for pattern separation during learning. We also found that nicotine enhanced granule cell (but not in GABAergic interneurons) activity in an α7 nAChR‐dependent manner via in vivo fibre photometry recording. Based on our findings, we propose that differential responses to α7 nAChR activation between granule cells and GABAergic interneurons is responsible for the increase of excitation by α7 nAChR agonists in hippocampal circuits synergistically." @default.
• W3198625084 created "2021-09-13" @default.
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• W3198625084 date "2021-09-28" @default.
• W3198625084 modified "2023-09-24" @default.
• W3198625084 title "Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus <i>in vitro</i> and <i>in vivo</i>" @default.
• W3198625084 cites W1531195113 @default.
• W3198625084 cites W1536586062 @default.
• W3198625084 cites W1540854925 @default.
• W3198625084 cites W1555632753 @default.
• W3198625084 cites W1637207518 @default.
• W3198625084 cites W1647659114 @default.
• W3198625084 cites W1900806927 @default.
• W3198625084 cites W1934489743 @default.
• W3198625084 cites W1964188222 @default.
• W3198625084 cites W1969006334 @default.
• W3198625084 cites W1973998682 @default.
• W3198625084 cites W1974896979 @default.
• W3198625084 cites W1977473971 @default.
• W3198625084 cites W1981195606 @default.
• W3198625084 cites W1981201955 @default.
• W3198625084 cites W1987297260 @default.
• W3198625084 cites W1992673078 @default.
• W3198625084 cites W1997470921 @default.
• W3198625084 cites W2004695318 @default.
• W3198625084 cites W2012199594 @default.
• W3198625084 cites W2014025108 @default.
• W3198625084 cites W2017298842 @default.
• W3198625084 cites W2017721215 @default.
• W3198625084 cites W2017753442 @default.
• W3198625084 cites W2018885303 @default.
• W3198625084 cites W2020028892 @default.
• W3198625084 cites W2024459482 @default.
• W3198625084 cites W2026331058 @default.
• W3198625084 cites W2028236452 @default.
• W3198625084 cites W2028486882 @default.
• W3198625084 cites W2030822454 @default.
• W3198625084 cites W2033237251 @default.
• W3198625084 cites W2034447969 @default.
• W3198625084 cites W2037554926 @default.
• W3198625084 cites W2037637272 @default.
• W3198625084 cites W2038988613 @default.
• W3198625084 cites W2041313121 @default.
• W3198625084 cites W2045546690 @default.
• W3198625084 cites W2049850657 @default.
• W3198625084 cites W2050455764 @default.
• W3198625084 cites W2052722557 @default.
• W3198625084 cites W2059495695 @default.
• W3198625084 cites W2062419094 @default.
• W3198625084 cites W2062607123 @default.
• W3198625084 cites W2068608417 @default.
• W3198625084 cites W2069065352 @default.
• W3198625084 cites W2071231521 @default.
• W3198625084 cites W2077887990 @default.
• W3198625084 cites W2078953408 @default.
• W3198625084 cites W2079296713 @default.
• W3198625084 cites W2085534172 @default.
• W3198625084 cites W2089963291 @default.
• W3198625084 cites W2090019512 @default.
• W3198625084 cites W2092284040 @default.
• W3198625084 cites W2096475568 @default.
• W3198625084 cites W2098005352 @default.
• W3198625084 cites W2102728574 @default.
• W3198625084 cites W2104027449 @default.
• W3198625084 cites W2104838343 @default.
• W3198625084 cites W2109277137 @default.
• W3198625084 cites W2112157534 @default.
• W3198625084 cites W2117649172 @default.
• W3198625084 cites W2121005897 @default.
• W3198625084 cites W2121980088 @default.
• W3198625084 cites W2126962049 @default.
• W3198625084 cites W2135895844 @default.
• W3198625084 cites W2137751464 @default.
• W3198625084 cites W2142847155 @default.
• W3198625084 cites W2144573332 @default.
• W3198625084 cites W2144841709 @default.
• W3198625084 cites W2153060249 @default.
• W3198625084 cites W2155797616 @default.
• W3198625084 cites W2161214225 @default.
• W3198625084 cites W2171332611 @default.
• W3198625084 cites W2258786360 @default.
• W3198625084 cites W2332441838 @default.
• W3198625084 cites W2339796267 @default.
• W3198625084 cites W2403699353 @default.
• W3198625084 cites W2416353382 @default.
• W3198625084 cites W2466250052 @default.
• W3198625084 cites W2581980900 @default.
• W3198625084 cites W2582675973 @default.
• W3198625084 cites W2607855507 @default.
• W3198625084 cites W2623452169 @default.
• W3198625084 cites W2791433556 @default.
• W3198625084 cites W2802223125 @default.

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