Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198643627> ?p ?o ?g. }
- W3198643627 abstract "Abstract Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and important regulator of the DNA damage response (DDR). One critical ATM target is the structural subunit A (PR65) of protein phosphatase 2A (PP2A), known to regulate diverse cellular processes such as mitosis and cell growth as well as dephosphorylating many proteins during the recovery from the DDR. We generated mouse embryonic fibroblasts expressing PR65-WT, -S401A (cannot be phosphorylated), and -S401D (phosphomimetic) transgenes. Significantly, S401 mutants exhibited extensive chromosomal aberrations, impaired DNA double-strand break (DSB) repair and underwent increased mitotic catastrophe after radiation. Our study demonstrates that the phosphorylation of a single, critical PR65 amino acid (S401) by ATM fundamentally controls the DDR, and balances DSB repair quality, cell survival and growth by spatiotemporal PR65 nuclear-cytoplasmic shuttling mediated by the nuclear export receptor CRM1." @default.
- W3198643627 created "2021-09-13" @default.
- W3198643627 creator A5007894073 @default.
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- W3198643627 creator A5089750727 @default.
- W3198643627 date "2021-08-29" @default.
- W3198643627 modified "2023-09-23" @default.
- W3198643627 title "ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response" @default.
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