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- W3198652121 abstract "Abstract The balance between ubiquitination and deubiquitination is critical for the degradation, transport, localization, and activity of proteins. Deubiquitinating enzymes (DUBs) greatly contribute to the balance of ubiquitination and deubiquitination, and they have been widely studied due to their fundamental role in cancer. DUB3/ubiquitin-specific protease 17 (USP17) is a type of DUB that has attracted much attention in cancer research. In this review, we summarize the biological functions and regulatory mechanisms of USP17 in central nervous system, head and neck, thoracic, breast, gastrointestinal, genitourinary, and gynecologic cancers as well as bone and soft tissue sarcomas, and we provide new insights into how USP17 can be used in the management of cancer." @default.
- W3198652121 created "2021-09-13" @default.
- W3198652121 creator A5006651636 @default.
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- W3198652121 creator A5053584749 @default.
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- W3198652121 creator A5087859394 @default.
- W3198652121 date "2021-08-28" @default.
- W3198652121 modified "2023-10-18" @default.
- W3198652121 title "The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review" @default.
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- W3198652121 doi "https://doi.org/10.1186/s12935-021-02160-y" @default.
- W3198652121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8400843" @default.
- W3198652121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34454495" @default.