FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198668715> ?p ?o ?g. }

• W3198668715 endingPage "9584" @default.
• W3198668715 startingPage "9584" @default.
• W3198668715 abstract "Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrated by adoptive transfer of disease in a model of experimental autoimmune uveitis (EAU). CD4+FoxP3+CD25+ regulatory T cells (Tregs) were known to suppress function of effector CD4+ T cells and contribute to resolution of disease. It has been recently reported that some CD4+ T-cell subsets demonstrate shared phenotypes with another CD4+ T-cell subset, offering the potential for dual function. For example, Th17/Th1 (co-expressing IFNγ and IL-17) cells and Th17/Treg (co-expressing IL-17 and FoxP3) cells have been identified in NIU and EAU. In this review, we have investigated the evidence as to whether these 'plastic CD4+ T cells' are functionally active in uveitis. We conclude that Th17/Th1 cells are generated locally, are resistant to the immunosuppressive effects of steroids, and contribute to early development of EAU. Th17/Treg cells produce IL-17, not IL-10, and act similar to Th17 cells. These cells were considered pathogenic in uveitis. Future studies are needed to better clarify their function, and in the future, these cell subsets may in need to be taken into consideration for designing treatment strategies for disease." @default.
• W3198668715 created "2021-09-13" @default.
• W3198668715 creator A5035420913 @default.
• W3198668715 creator A5049002575 @default.
• W3198668715 creator A5059361239 @default.
• W3198668715 date "2021-09-03" @default.
• W3198668715 modified "2023-10-01" @default.
• W3198668715 title "CD4+ T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease" @default.
• W3198668715 cites W1494340582 @default.
• W3198668715 cites W1503370241 @default.
• W3198668715 cites W1516263086 @default.
• W3198668715 cites W1523458199 @default.
• W3198668715 cites W1547617634 @default.
• W3198668715 cites W1586034815 @default.
• W3198668715 cites W1597985804 @default.
• W3198668715 cites W1633194666 @default.
• W3198668715 cites W1787048953 @default.
• W3198668715 cites W1880955151 @default.
• W3198668715 cites W1906467669 @default.
• W3198668715 cites W1928412993 @default.
• W3198668715 cites W1965673490 @default.
• W3198668715 cites W1998350666 @default.
• W3198668715 cites W2002726823 @default.
• W3198668715 cites W2011446655 @default.
• W3198668715 cites W2011882192 @default.
• W3198668715 cites W2012680181 @default.
• W3198668715 cites W2013212307 @default.
• W3198668715 cites W2017502688 @default.
• W3198668715 cites W2017893786 @default.
• W3198668715 cites W2021340905 @default.
• W3198668715 cites W2029628152 @default.
• W3198668715 cites W2049275241 @default.
• W3198668715 cites W2050766359 @default.
• W3198668715 cites W2061217789 @default.
• W3198668715 cites W2069973251 @default.
• W3198668715 cites W2073946511 @default.
• W3198668715 cites W2077982842 @default.
• W3198668715 cites W2083459951 @default.
• W3198668715 cites W2086880284 @default.
• W3198668715 cites W2090069133 @default.
• W3198668715 cites W2090544921 @default.
• W3198668715 cites W2096030110 @default.
• W3198668715 cites W2104040734 @default.
• W3198668715 cites W2104401957 @default.
• W3198668715 cites W2115483836 @default.
• W3198668715 cites W2122586908 @default.
• W3198668715 cites W2130337837 @default.
• W3198668715 cites W2135657138 @default.
• W3198668715 cites W2144288685 @default.
• W3198668715 cites W2152390002 @default.
• W3198668715 cites W2152981095 @default.
• W3198668715 cites W2158882856 @default.
• W3198668715 cites W2162656915 @default.
• W3198668715 cites W2206185415 @default.
• W3198668715 cites W2284327277 @default.
• W3198668715 cites W2300048866 @default.
• W3198668715 cites W2346805035 @default.
• W3198668715 cites W2395562272 @default.
• W3198668715 cites W2400343837 @default.
• W3198668715 cites W2531618997 @default.
• W3198668715 cites W2551812833 @default.
• W3198668715 cites W2578062412 @default.
• W3198668715 cites W2599441629 @default.
• W3198668715 cites W2606010780 @default.
• W3198668715 cites W2618420738 @default.
• W3198668715 cites W2719999682 @default.
• W3198668715 cites W277472989 @default.
• W3198668715 cites W2777481836 @default.
• W3198668715 cites W2789298540 @default.
• W3198668715 cites W2791244813 @default.
• W3198668715 cites W2792515464 @default.
• W3198668715 cites W2801927842 @default.
• W3198668715 cites W2804313194 @default.
• W3198668715 cites W2804672406 @default.
• W3198668715 cites W2805728976 @default.
• W3198668715 cites W2888146979 @default.
• W3198668715 cites W2889562046 @default.
• W3198668715 cites W2909631583 @default.
• W3198668715 cites W2913838241 @default.
• W3198668715 cites W2917674194 @default.
• W3198668715 cites W2920900903 @default.
• W3198668715 cites W2921583995 @default.
• W3198668715 cites W2966125339 @default.
• W3198668715 cites W2972371423 @default.
• W3198668715 cites W2977559163 @default.
• W3198668715 cites W2981607720 @default.
• W3198668715 cites W2996467337 @default.
• W3198668715 cites W3004513021 @default.
• W3198668715 cites W3011470684 @default.
• W3198668715 cites W3012538686 @default.
• W3198668715 cites W3030632859 @default.
• W3198668715 cites W3041092590 @default.
• W3198668715 cites W3043321092 @default.
• W3198668715 cites W3088144672 @default.
• W3198668715 cites W3128043656 @default.
• W3198668715 cites W3130574916 @default.
• W3198668715 cites W3159143722 @default.
• W3198668715 cites W3159742475 @default.

• next