Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198702987> ?p ?o ?g. }
- W3198702987 abstract "Genetic alterations of somatic cells can drive non-malignant clone formation and promote cancer initiation. However, the link between these processes remains unclear hampering our understanding of tissue homeostasis and cancer development. Here we collect a literature-based repertoire of 3355 well-known or predicted drivers of cancer and noncancer somatic evolution in 122 cancer types and 12 noncancer tissues. Mapping the alterations of these genes in 7953 pancancer samples reveals that, despite the large size, the known compendium of drivers is still incomplete and biased towards frequently occurring coding mutations. High overlap exists between drivers of cancer and noncancer somatic evolution, although significant differences emerge in their recurrence. We confirm and expand the unique properties of drivers and identify a core of evolutionarily conserved and essential genes whose germline variation is strongly counter-selected. Somatic alteration in even one of these genes is sufficient to drive clonal expansion but not malignant transformation. Our study offers a comprehensive overview of our current understanding of the genetic events initiating clone expansion and cancer revealing significant gaps and biases that still need to be addressed. The compendium of cancer and noncancer somatic drivers, their literature support and properties are accessible at http://www.network-cancer-genes.org/." @default.
- W3198702987 created "2021-09-13" @default.
- W3198702987 creator A5011761561 @default.
- W3198702987 creator A5022834340 @default.
- W3198702987 creator A5025554976 @default.
- W3198702987 creator A5026743581 @default.
- W3198702987 creator A5026962816 @default.
- W3198702987 creator A5027834613 @default.
- W3198702987 creator A5028555570 @default.
- W3198702987 creator A5047607978 @default.
- W3198702987 creator A5049181593 @default.
- W3198702987 creator A5049375441 @default.
- W3198702987 creator A5050582956 @default.
- W3198702987 creator A5054039730 @default.
- W3198702987 creator A5062362789 @default.
- W3198702987 creator A5070764087 @default.
- W3198702987 creator A5075349598 @default.
- W3198702987 creator A5079060695 @default.
- W3198702987 date "2021-08-31" @default.
- W3198702987 modified "2023-09-27" @default.
- W3198702987 title "Comparative assessment of genes driving cancer and somatic evolution." @default.
- W3198702987 cites W1507311685 @default.
- W3198702987 cites W1563940013 @default.
- W3198702987 cites W1922783847 @default.
- W3198702987 cites W1956871134 @default.
- W3198702987 cites W1984068087 @default.
- W3198702987 cites W1989277387 @default.
- W3198702987 cites W2000800050 @default.
- W3198702987 cites W2003567202 @default.
- W3198702987 cites W2003907692 @default.
- W3198702987 cites W2006288875 @default.
- W3198702987 cites W2006290700 @default.
- W3198702987 cites W2009720434 @default.
- W3198702987 cites W2012034410 @default.
- W3198702987 cites W2022495797 @default.
- W3198702987 cites W2022945065 @default.
- W3198702987 cites W2025183726 @default.
- W3198702987 cites W2033148943 @default.
- W3198702987 cites W2037324746 @default.
- W3198702987 cites W2038473742 @default.
- W3198702987 cites W2043764521 @default.
- W3198702987 cites W2044433401 @default.
- W3198702987 cites W2064181369 @default.
- W3198702987 cites W2076357933 @default.
- W3198702987 cites W2097113581 @default.
- W3198702987 cites W2097238709 @default.
- W3198702987 cites W2101412130 @default.
- W3198702987 cites W2104549677 @default.
- W3198702987 cites W2111326065 @default.
- W3198702987 cites W2112947018 @default.
- W3198702987 cites W2114029728 @default.
- W3198702987 cites W2117053783 @default.
- W3198702987 cites W2121906867 @default.
- W3198702987 cites W2122164259 @default.
- W3198702987 cites W2122863289 @default.
- W3198702987 cites W2123227225 @default.
- W3198702987 cites W2130687290 @default.
- W3198702987 cites W2134118500 @default.
- W3198702987 cites W2139227366 @default.
- W3198702987 cites W2141783822 @default.
- W3198702987 cites W2143238378 @default.
- W3198702987 cites W2145187337 @default.
- W3198702987 cites W2152176732 @default.
- W3198702987 cites W2155845523 @default.
- W3198702987 cites W2159987716 @default.
- W3198702987 cites W2167852161 @default.
- W3198702987 cites W2169703913 @default.
- W3198702987 cites W2173732482 @default.
- W3198702987 cites W2174734928 @default.
- W3198702987 cites W2338215681 @default.
- W3198702987 cites W2436745791 @default.
- W3198702987 cites W2461427403 @default.
- W3198702987 cites W2547802404 @default.
- W3198702987 cites W2559588208 @default.
- W3198702987 cites W2560629097 @default.
- W3198702987 cites W2565848986 @default.
- W3198702987 cites W2604059488 @default.
- W3198702987 cites W2611187032 @default.
- W3198702987 cites W2734649221 @default.
- W3198702987 cites W2735132087 @default.
- W3198702987 cites W2741508285 @default.
- W3198702987 cites W2742028015 @default.
- W3198702987 cites W2766971792 @default.
- W3198702987 cites W2767891136 @default.
- W3198702987 cites W2794113336 @default.
- W3198702987 cites W2795686629 @default.
- W3198702987 cites W2796153844 @default.
- W3198702987 cites W2796408191 @default.
- W3198702987 cites W2885069342 @default.
- W3198702987 cites W2894573839 @default.
- W3198702987 cites W2897064819 @default.
- W3198702987 cites W2898789672 @default.
- W3198702987 cites W2900629010 @default.
- W3198702987 cites W2901601883 @default.
- W3198702987 cites W2905667684 @default.
- W3198702987 cites W2907010214 @default.
- W3198702987 cites W2917858269 @default.
- W3198702987 cites W2923413293 @default.
- W3198702987 cites W2936686072 @default.
- W3198702987 cites W2944727022 @default.