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• W3198708524 abstract "As a widely used synthetic pyrethroid insecticide, deltamethrin (DM) causes serious health problems to aquatic organisms. However, the comprehensive understanding of the adverse effect of DM on aquatic organisms has received limited attention. In this study, goldfish (Carassius auratus) were exposed to 0 (control group), 0.2 and 2 µg/L DM for 96 h. The kidney transcriptome and intestinal microbiota were investigated. Comparative transcriptome analysis identified 270 and 711 differentially expressed genes (DEGs) in goldfish kidneys after exposure to 0.2 and 2 µg/L DM, respectively. KEGG pathway analysis revealed that the apoptosis pathway was markedly regulated and the regulation of programmed cell death was significantly enriched by the GO analysis. Several apoptosis-related genes including cathepsin L and cytochrome c were also detected. These results indicated that apoptosis occurred in the goldfish kidney after acute exposure to sublethal concentration of DM. Besides, some immune and drug metabolism-related DEGs were identified, indicating that exposure to DM caused immunotoxicity and metabolic disruption in goldfish. Additionally, 16 S rRNA gene sequencing analysis revealed a remarkable alteration in the composition of the intestinal microbial community of DM-treated goldfish. At the phylum level, the abundance of Proteobacteria, Firmicutes and Fusobacteria was increased, whereas the abundance of Bacteroidetes was reduced significantly after DM exposure. At the genus level, the abundance of Aeromonas, Cetobacterium, Dielma and Pseudorhodobacter was reduced, whereas Akkermansia was increased after DM exposure. In summary, exposure to DM could induce apoptosis and immunotoxicity in goldfish kidneys and affect the composition of the intestinal microbiota in goldfish. This study provides a comprehensive analysis of the adverse effect of DM exposure on the goldfish and will be helpful for understanding the toxicological mechanisms of DM in fish." @default.
• W3198708524 created "2021-09-13" @default.
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• W3198708524 date "2021-12-01" @default.
• W3198708524 modified "2023-10-14" @default.
• W3198708524 title "Effects of acute deltamethrin exposure on kidney transcriptome and intestinal microbiota in goldfish (Carassius auratus)" @default.
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• W3198708524 doi "https://doi.org/10.1016/j.ecoenv.2021.112716" @default.
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