Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198730115> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3198730115 abstract "IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disease, affecting 1% of the population over 60 years of age. PD pathology is characterised by the loss of dopaminergic neurons from the substantia nigra and the formation of neuronal inclusions called Lewy bodies. The development of PD involves a complex interaction of genetic and environmental factors. Many of the genetic factors affecting disease progression have been identified but there is much still to be determined. This is particularly true for those factors not causative of the disease, but progression and severity of the disease once diagnosed. We aim to address both genetic and transcriptomic changes which we can bioinformatically identify in the Parkinson’s Progression Markers Initiative (PPMI) cohort which was established to identify PD progression markers to help understand disease aetiology and ultimately aid in the development of novel therapeutics.MethodsGenetic data, longitudinal clinical data and transcriptomic data has been obtained from the Parkinson’s Progression Markers Initiative (PPMI) cohort (www.ppmi-info.org). The DESeq2 package in R will be used to detect statistically significant differences in the gene expression profiles between the different genotypes which we are currently delineating to correlate with specific clinical progression markers. This will allow us to align genetic variation with blood transcriptomic changes with disease progression.Approach for statistical analysisOnce we have identified targets using DESeq2, their association with PD progression will be analysed in the longitudinal analysis using a linear mixed-effects model combined with FDR correction, measuring the changes in phenotypic scores during follow-up visits that will later be analysed." @default.
- W3198730115 created "2021-09-13" @default.
- W3198730115 creator A5000265622 @default.
- W3198730115 creator A5037963150 @default.
- W3198730115 creator A5039050152 @default.
- W3198730115 creator A5061510230 @default.
- W3198730115 creator A5063620741 @default.
- W3198730115 creator A5080410245 @default.
- W3198730115 date "2021-01-01" @default.
- W3198730115 modified "2023-10-17" @default.
- W3198730115 title "Identification of molecular markers that correlate with the progression of Parkinson’s Disease" @default.
- W3198730115 hasPublicationYear "2021" @default.
- W3198730115 type Work @default.
- W3198730115 sameAs 3198730115 @default.
- W3198730115 citedByCount "0" @default.
- W3198730115 crossrefType "journal-article" @default.
- W3198730115 hasAuthorship W3198730115A5000265622 @default.
- W3198730115 hasAuthorship W3198730115A5037963150 @default.
- W3198730115 hasAuthorship W3198730115A5039050152 @default.
- W3198730115 hasAuthorship W3198730115A5061510230 @default.
- W3198730115 hasAuthorship W3198730115A5063620741 @default.
- W3198730115 hasAuthorship W3198730115A5080410245 @default.
- W3198730115 hasConcept C104317684 @default.
- W3198730115 hasConcept C142724271 @default.
- W3198730115 hasConcept C150194340 @default.
- W3198730115 hasConcept C162317418 @default.
- W3198730115 hasConcept C2779134260 @default.
- W3198730115 hasConcept C2779734285 @default.
- W3198730115 hasConcept C2780938664 @default.
- W3198730115 hasConcept C2908647359 @default.
- W3198730115 hasConcept C54355233 @default.
- W3198730115 hasConcept C60644358 @default.
- W3198730115 hasConcept C69991583 @default.
- W3198730115 hasConcept C71924100 @default.
- W3198730115 hasConcept C86803240 @default.
- W3198730115 hasConcept C99454951 @default.
- W3198730115 hasConceptScore W3198730115C104317684 @default.
- W3198730115 hasConceptScore W3198730115C142724271 @default.
- W3198730115 hasConceptScore W3198730115C150194340 @default.
- W3198730115 hasConceptScore W3198730115C162317418 @default.
- W3198730115 hasConceptScore W3198730115C2779134260 @default.
- W3198730115 hasConceptScore W3198730115C2779734285 @default.
- W3198730115 hasConceptScore W3198730115C2780938664 @default.
- W3198730115 hasConceptScore W3198730115C2908647359 @default.
- W3198730115 hasConceptScore W3198730115C54355233 @default.
- W3198730115 hasConceptScore W3198730115C60644358 @default.
- W3198730115 hasConceptScore W3198730115C69991583 @default.
- W3198730115 hasConceptScore W3198730115C71924100 @default.
- W3198730115 hasConceptScore W3198730115C86803240 @default.
- W3198730115 hasConceptScore W3198730115C99454951 @default.
- W3198730115 hasLocation W31987301151 @default.
- W3198730115 hasOpenAccess W3198730115 @default.
- W3198730115 hasPrimaryLocation W31987301151 @default.
- W3198730115 hasRelatedWork W1591882542 @default.
- W3198730115 hasRelatedWork W1672729420 @default.
- W3198730115 hasRelatedWork W1987772140 @default.
- W3198730115 hasRelatedWork W2089417946 @default.
- W3198730115 hasRelatedWork W2391916905 @default.
- W3198730115 hasRelatedWork W2560185208 @default.
- W3198730115 hasRelatedWork W2600061020 @default.
- W3198730115 hasRelatedWork W2795901169 @default.
- W3198730115 hasRelatedWork W2923128455 @default.
- W3198730115 hasRelatedWork W2923963235 @default.
- W3198730115 hasRelatedWork W2933150635 @default.
- W3198730115 hasRelatedWork W2966994499 @default.
- W3198730115 hasRelatedWork W2986932567 @default.
- W3198730115 hasRelatedWork W3003733514 @default.
- W3198730115 hasRelatedWork W3097107670 @default.
- W3198730115 hasRelatedWork W3111453743 @default.
- W3198730115 hasRelatedWork W3113344914 @default.
- W3198730115 hasRelatedWork W3153760013 @default.
- W3198730115 hasRelatedWork W3157584621 @default.
- W3198730115 hasRelatedWork W3157671732 @default.
- W3198730115 isParatext "false" @default.
- W3198730115 isRetracted "false" @default.
- W3198730115 magId "3198730115" @default.
- W3198730115 workType "article" @default.