Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198731203> ?p ?o ?g. }
- W3198731203 endingPage "109760" @default.
- W3198731203 startingPage "109760" @default.
- W3198731203 abstract "Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike receptor-binding domains (RBDs). Potent antibodies recognize exposed variable epitopes, often rendering them ineffective against other sarbecoviruses and SARS-CoV-2 variants. Class 4 anti-RBD antibodies against a less-exposed, but more-conserved, cryptic epitope could recognize newly emergent zoonotic sarbecoviruses and variants, but they usually show only weak neutralization potencies. Here, we characterize two class 4 anti-RBD antibodies derived from coronavirus disease 2019 (COVID-19) donors that exhibit breadth and potent neutralization of zoonotic coronaviruses and SARS-CoV-2 variants. C118-RBD and C022-RBD structures reveal orientations that extend from the cryptic epitope to occlude ACE2 binding and CDRH3-RBD main-chain H-bond interactions that extend an RBD β sheet, thus reducing sensitivity to RBD side-chain changes. A C118-spike trimer structure reveals rotated RBDs that allow access to the cryptic epitope and the potential for intra-spike crosslinking to increase avidity. These studies facilitate vaccine design and illustrate potential advantages of class 4 RBD-binding antibody therapeutics." @default.
- W3198731203 created "2021-09-13" @default.
- W3198731203 creator A5001960560 @default.
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- W3198731203 creator A5075580808 @default.
- W3198731203 creator A5080976451 @default.
- W3198731203 creator A5082602129 @default.
- W3198731203 date "2021-09-01" @default.
- W3198731203 modified "2023-10-03" @default.
- W3198731203 title "Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies" @default.
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