Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198743060> ?p ?o ?g. }
- W3198743060 abstract "ABSTRACT Benzene is a ubiquitous environmental pollutant abundant in household products, petrochemicals and cigarette smoke. Benzene is a well-known carcinogen in humans and experimental animals; however, little is known about the cardiovascular toxicity of benzene. Recent population-based studies indicate that benzene exposure is associated with an increased risk for heart failure. Nonetheless, it is unclear whether benzene exposure is sufficient to induce and/or exacerbate heart failure. We examined the effects of benzene (50 ppm, 6 h/day, 5 days/week, 6 weeks) or HEPA-filtered air exposure on transverse aortic constriction (TAC)-induced pressure overload in male C57BL/6J mice. Our data show that benzene exposure had no effect on cardiac function in the Sham group; however, it significantly compromised cardiac function as depicted by a significant decrease in fractional shortening and ejection fraction, as compared with TAC/Air-exposed mice. RNA-seq analysis of the cardiac tissue from the TAC/benzene-exposed mice showed a significant increase in several genes associated with adhesion molecules, cell-cell adhesion, inflammation, and stress response. In particular, neutrophils were implicated in our unbiased analyses. Indeed, immunofluorescence studies showed that TAC/benzene exposure promotes infiltration of CD11b + /S100A8 + /myeloperoxidase + -positive neutrophils in the hearts by 3-fold. In vitro , the benzene metabolites, hydroquinone and catechol, induced the expression of P-selectin in cardiac microvascular endothelial cells by 5-fold and increased the adhesion of neutrophils to these endothelial cells by 1.5-2.0-fold. Benzene metabolite-induced adhesion of neutrophils to the endothelial cells was attenuated by anti-P-selectin antibody. Together, these data suggest that benzene exacerbates heart failure by promoting endothelial activation and neutrophil recruitment." @default.
- W3198743060 created "2021-09-13" @default.
- W3198743060 creator A5004341480 @default.
- W3198743060 creator A5022942037 @default.
- W3198743060 creator A5029068853 @default.
- W3198743060 creator A5033301238 @default.
- W3198743060 creator A5042972055 @default.
- W3198743060 creator A5068870480 @default.
- W3198743060 creator A5069642403 @default.
- W3198743060 creator A5073128502 @default.
- W3198743060 creator A5077668308 @default.
- W3198743060 creator A5085078340 @default.
- W3198743060 date "2021-09-01" @default.
- W3198743060 modified "2023-10-18" @default.
- W3198743060 title "Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction" @default.
- W3198743060 cites W1534544091 @default.
- W3198743060 cites W1574813722 @default.
- W3198743060 cites W1617145133 @default.
- W3198743060 cites W1772965091 @default.
- W3198743060 cites W1950981769 @default.
- W3198743060 cites W1959096812 @default.
- W3198743060 cites W1976958879 @default.
- W3198743060 cites W1987980227 @default.
- W3198743060 cites W1994435105 @default.
- W3198743060 cites W2004854264 @default.
- W3198743060 cites W2008100685 @default.
- W3198743060 cites W2010009857 @default.
- W3198743060 cites W2011066397 @default.
- W3198743060 cites W2026982233 @default.
- W3198743060 cites W2032885597 @default.
- W3198743060 cites W2039493826 @default.
- W3198743060 cites W2047082557 @default.
- W3198743060 cites W2047742688 @default.
- W3198743060 cites W2060157902 @default.
- W3198743060 cites W2062191985 @default.
- W3198743060 cites W2075424611 @default.
- W3198743060 cites W2087588341 @default.
- W3198743060 cites W2089869264 @default.
- W3198743060 cites W2094005996 @default.
- W3198743060 cites W2094112735 @default.
- W3198743060 cites W2097883765 @default.
- W3198743060 cites W2113181569 @default.
- W3198743060 cites W2114349116 @default.
- W3198743060 cites W2118556847 @default.
- W3198743060 cites W2120212913 @default.
- W3198743060 cites W2125021772 @default.
- W3198743060 cites W2135647797 @default.
- W3198743060 cites W2137625135 @default.
- W3198743060 cites W2138875549 @default.
- W3198743060 cites W2145120842 @default.
- W3198743060 cites W2151192297 @default.
- W3198743060 cites W2152865365 @default.
- W3198743060 cites W2153960708 @default.
- W3198743060 cites W2157963791 @default.
- W3198743060 cites W2165603390 @default.
- W3198743060 cites W2286929259 @default.
- W3198743060 cites W2303631778 @default.
- W3198743060 cites W2363034775 @default.
- W3198743060 cites W2405252795 @default.
- W3198743060 cites W2479827938 @default.
- W3198743060 cites W2520605125 @default.
- W3198743060 cites W2566308673 @default.
- W3198743060 cites W2575729422 @default.
- W3198743060 cites W2580272850 @default.
- W3198743060 cites W2580792129 @default.
- W3198743060 cites W2608650231 @default.
- W3198743060 cites W2625043609 @default.
- W3198743060 cites W2750745925 @default.
- W3198743060 cites W2765710198 @default.
- W3198743060 cites W2779319275 @default.
- W3198743060 cites W2791059232 @default.
- W3198743060 cites W2791204980 @default.
- W3198743060 cites W2792454313 @default.
- W3198743060 cites W2795410215 @default.
- W3198743060 cites W2800905301 @default.
- W3198743060 cites W2802674382 @default.
- W3198743060 cites W2805322110 @default.
- W3198743060 cites W2806120329 @default.
- W3198743060 cites W2885260642 @default.
- W3198743060 cites W2890977746 @default.
- W3198743060 cites W2955166257 @default.
- W3198743060 cites W2961010215 @default.
- W3198743060 cites W2979791414 @default.
- W3198743060 cites W2982367920 @default.
- W3198743060 cites W3003281746 @default.
- W3198743060 cites W4361974188 @default.
- W3198743060 doi "https://doi.org/10.1101/2021.08.31.458367" @default.
- W3198743060 hasPublicationYear "2021" @default.
- W3198743060 type Work @default.
- W3198743060 sameAs 3198743060 @default.
- W3198743060 citedByCount "0" @default.
- W3198743060 crossrefType "posted-content" @default.
- W3198743060 hasAuthorship W3198743060A5004341480 @default.
- W3198743060 hasAuthorship W3198743060A5022942037 @default.
- W3198743060 hasAuthorship W3198743060A5029068853 @default.
- W3198743060 hasAuthorship W3198743060A5033301238 @default.
- W3198743060 hasAuthorship W3198743060A5042972055 @default.
- W3198743060 hasAuthorship W3198743060A5068870480 @default.
- W3198743060 hasAuthorship W3198743060A5069642403 @default.
- W3198743060 hasAuthorship W3198743060A5073128502 @default.