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- W3198754559 abstract "Abstract Rosmarinic acid (RS) is as the nonflavonoid polyphenols in the phenolic acid subgroup was cross‐linked with sodium trimetaphosphate (STMP) to obtain (p[RS‐co‐STMP]) particles with the size distribution of 2.992 ± 659 nm. The zeta potential values of p(RS‐co‐STMP) particles were measured between pH 2–10, and the isoelectric point was determined as pH 2.66. Fe(II) chelating capability test was done for RS and p(RS‐co‐STMP). At 800 μmol/ml concentrations, p(RS‐co‐STMP) particles chelated 95.06 ± 5.18% Fe(II), while RS molecule did not chelate Fe(II), whereas STMP chelated only 41.8 ± 5.9% Fe(II). The effects of RS and p(RS‐co‐STMP) particles on α‐glucosidase enzyme activity were investigated and were found to inhibit the α‐glucosidase enzyme by 55.7% and 89.6%, respectively. Furthermore, p(RS‐co‐STMP) particles were modified with polyethyleneimine as m‐p(RS‐co‐STMP) to improve antimicrobial properties and found effective against both Escherichia coli and Staphylococcus aureus bacteria. The interaction of fibrinogen with RS, p(RS‐co‐STMP) and m‐p(RS‐co‐STMP) were studied via the change in intensity of corresponding fluorescence spectra. It was found that p(RS‐co‐STMP) particles interacted lesser with fibrinogen than RS and changed the fluorescence property of fibrinogen protein slightly. On the other hand, m‐p(RS‐co‐STMP) particles did not change the fluorescence intensity of fibrinogen suggesting no influence on the blood clotting." @default.
- W3198754559 created "2021-09-13" @default.
- W3198754559 creator A5050169215 @default.
- W3198754559 date "2021-08-26" @default.
- W3198754559 modified "2023-09-30" @default.
- W3198754559 title "Hydrolytic nondegradable bioactive rosmarinic acid particles" @default.
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- W3198754559 doi "https://doi.org/10.1002/pat.5481" @default.
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