FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198763602> ?p ?o ?g. }

• W3198763602 endingPage "1094" @default.
• W3198763602 startingPage "1083" @default.
• W3198763602 abstract "Little is known about the relationship between lipoprotein (a) [Lp(a)] and high-sensitivity C-reactive protein (hsCRP) and their joint association with atherosclerotic cardiovascular disease (ASCVD).The purpose of this study was to assess whether Lp(a)-associated ASCVD risk is modified by hsCRP in the context of primary prevention.The current study included 4,679 participants from the MESA (Multi-Ethnic Study of Atherosclerosis) Apolipoprotein ancillary data set. Cox proportional hazards models and Kaplan-Meier curves were used to assess the association among Lp(a), hsCRP, and time to cardiovascular disease (CVD) events.During a mean follow-up of 13.6 years, 684 CVD events occurred. A significant interaction was observed between Lp(a) and hsCRP (P = 0.04). With hsCRP <2 mg/L, no significant CVD risk was observed at any level of Lp(a) from <50 mg/dL to >100 mg/dL. However, with hsCRP ≥2 mg/L, a significant CVD risk was observed with Lp(a) of 50-99.9 mg/dL (HR: 1.36; 95% CI: 1.02-1.81) and Lp(a) ≥100 mg/dL (HR: 2.09; 95% CI: 1.40-3.13). Isolated elevations of either Lp(a) or hsCRP were not associated with increased CVD risk. In contrast, the combination of elevated Lp(a) (≥50 mg/dL) and hsCRP (≥2 mg/L) was independently associated with significant CVD risk (HR: 1.62; 95% CI: 1.25-2.10) and all-cause mortality (HR: 1.39; 95% CI: 1.12-1.72).Lp(a)-associated ASCVD risk is observed only with concomitant elevation of hsCRP. Individuals with concomitant presence of elevated Lp(a) and systemic inflammation have greater ASCVD risk and all-cause mortality, and thus may merit closer surveillance and more aggressive ASCVD risk management." @default.
• W3198763602 created "2021-09-13" @default.
• W3198763602 creator A5002393925 @default.
• W3198763602 creator A5003912464 @default.
• W3198763602 creator A5022083191 @default.
• W3198763602 creator A5054715840 @default.
• W3198763602 creator A5071844909 @default.
• W3198763602 creator A5072450097 @default.
• W3198763602 creator A5073734270 @default.
• W3198763602 creator A5076699095 @default.
• W3198763602 date "2021-09-01" @default.
• W3198763602 modified "2023-10-18" @default.
• W3198763602 title "High-Sensitivity C-Reactive Protein Modifies the Cardiovascular Risk of Lipoprotein(a)" @default.
• W3198763602 cites W149694075 @default.
• W3198763602 cites W1985882893 @default.
• W3198763602 cites W1988877980 @default.
• W3198763602 cites W1990204315 @default.
• W3198763602 cites W2017602185 @default.
• W3198763602 cites W2091942341 @default.
• W3198763602 cites W2098230963 @default.
• W3198763602 cites W2104355263 @default.
• W3198763602 cites W2116404316 @default.
• W3198763602 cites W2130412576 @default.
• W3198763602 cites W2156097706 @default.
• W3198763602 cites W2222665820 @default.
• W3198763602 cites W2522418769 @default.
• W3198763602 cites W2586892149 @default.
• W3198763602 cites W2588744787 @default.
• W3198763602 cites W2596606986 @default.
• W3198763602 cites W2769000982 @default.
• W3198763602 cites W2786623458 @default.
• W3198763602 cites W2791615591 @default.
• W3198763602 cites W2797001350 @default.
• W3198763602 cites W2801713528 @default.
• W3198763602 cites W2894645224 @default.
• W3198763602 cites W2900034165 @default.
• W3198763602 cites W2913705661 @default.
• W3198763602 cites W2921012991 @default.
• W3198763602 cites W2986700515 @default.
• W3198763602 cites W2997944188 @default.
• W3198763602 cites W3024277681 @default.
• W3198763602 cites W3041932158 @default.
• W3198763602 cites W3129818723 @default.
• W3198763602 cites W3172996796 @default.
• W3198763602 doi "https://doi.org/10.1016/j.jacc.2021.07.016" @default.
• W3198763602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8444216" @default.
• W3198763602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34503676" @default.
• W3198763602 hasPublicationYear "2021" @default.
• W3198763602 type Work @default.
• W3198763602 sameAs 3198763602 @default.
• W3198763602 citedByCount "51" @default.
• W3198763602 countsByYear W31987636022021 @default.
• W3198763602 countsByYear W31987636022022 @default.
• W3198763602 countsByYear W31987636022023 @default.
• W3198763602 crossrefType "journal-article" @default.
• W3198763602 hasAuthorship W3198763602A5002393925 @default.
• W3198763602 hasAuthorship W3198763602A5003912464 @default.
• W3198763602 hasAuthorship W3198763602A5022083191 @default.
• W3198763602 hasAuthorship W3198763602A5054715840 @default.
• W3198763602 hasAuthorship W3198763602A5071844909 @default.
• W3198763602 hasAuthorship W3198763602A5072450097 @default.
• W3198763602 hasAuthorship W3198763602A5073734270 @default.
• W3198763602 hasAuthorship W3198763602A5076699095 @default.
• W3198763602 hasBestOaLocation W31987636022 @default.
• W3198763602 hasConcept C126322002 @default.
• W3198763602 hasConcept C151730666 @default.
• W3198763602 hasConcept C164705383 @default.
• W3198763602 hasConcept C2776104379 @default.
• W3198763602 hasConcept C2776914184 @default.
• W3198763602 hasConcept C2778163477 @default.
• W3198763602 hasConcept C2779134260 @default.
• W3198763602 hasConcept C2779343474 @default.
• W3198763602 hasConcept C2780072125 @default.
• W3198763602 hasConcept C2781195455 @default.
• W3198763602 hasConcept C2909478654 @default.
• W3198763602 hasConcept C50382708 @default.
• W3198763602 hasConcept C50440223 @default.
• W3198763602 hasConcept C71924100 @default.
• W3198763602 hasConcept C86803240 @default.
• W3198763602 hasConcept C90924648 @default.
• W3198763602 hasConceptScore W3198763602C126322002 @default.
• W3198763602 hasConceptScore W3198763602C151730666 @default.
• W3198763602 hasConceptScore W3198763602C164705383 @default.
• W3198763602 hasConceptScore W3198763602C2776104379 @default.
• W3198763602 hasConceptScore W3198763602C2776914184 @default.
• W3198763602 hasConceptScore W3198763602C2778163477 @default.
• W3198763602 hasConceptScore W3198763602C2779134260 @default.
• W3198763602 hasConceptScore W3198763602C2779343474 @default.
• W3198763602 hasConceptScore W3198763602C2780072125 @default.
• W3198763602 hasConceptScore W3198763602C2781195455 @default.
• W3198763602 hasConceptScore W3198763602C2909478654 @default.
• W3198763602 hasConceptScore W3198763602C50382708 @default.
• W3198763602 hasConceptScore W3198763602C50440223 @default.
• W3198763602 hasConceptScore W3198763602C71924100 @default.
• W3198763602 hasConceptScore W3198763602C86803240 @default.
• W3198763602 hasConceptScore W3198763602C90924648 @default.
• W3198763602 hasIssue "11" @default.
• W3198763602 hasLocation W31987636021 @default.

• next