Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198778002> ?p ?o ?g. }
- W3198778002 endingPage "1530" @default.
- W3198778002 startingPage "1519" @default.
- W3198778002 abstract "Astrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), morphologically distinct astrocytic subtypes were identified and could be linked to transcriptome changes during different disease stages and regions. To allow for continuous awareness of changing stimuli across age and diseases, astrocytes are equipped with a variety of receptors and ion channels allowing the precise perception of environmental cues. Recent studies implicate the diverse repertoire of astrocytic ion channels - including transient receptor potential channels, voltage-gated calcium channels, inwardly rectifying K+ channels, and two-pore domain potassium channels - in sensing the brain state in physiology, inflammation and ischemia. Here, we review current evidence regarding astrocytic potassium and calcium channels and their functional contribution in homeostasis, neuroinflammation and stroke." @default.
- W3198778002 created "2021-09-13" @default.
- W3198778002 creator A5018353476 @default.
- W3198778002 creator A5040381414 @default.
- W3198778002 creator A5074787603 @default.
- W3198778002 date "2021-08-30" @default.
- W3198778002 modified "2023-09-23" @default.
- W3198778002 title "Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment" @default.
- W3198778002 cites W1533562283 @default.
- W3198778002 cites W1593524216 @default.
- W3198778002 cites W1860574066 @default.
- W3198778002 cites W1935275454 @default.
- W3198778002 cites W1965395632 @default.
- W3198778002 cites W1967902520 @default.
- W3198778002 cites W1968479618 @default.
- W3198778002 cites W1970626055 @default.
- W3198778002 cites W1973204849 @default.
- W3198778002 cites W1975481849 @default.
- W3198778002 cites W1978836458 @default.
- W3198778002 cites W1985757780 @default.
- W3198778002 cites W1986477333 @default.
- W3198778002 cites W1987494414 @default.
- W3198778002 cites W199026230 @default.
- W3198778002 cites W1994292318 @default.
- W3198778002 cites W1995692886 @default.
- W3198778002 cites W1997894847 @default.
- W3198778002 cites W2008241137 @default.
- W3198778002 cites W2009614661 @default.
- W3198778002 cites W2009991455 @default.
- W3198778002 cites W2011152569 @default.
- W3198778002 cites W2014424306 @default.
- W3198778002 cites W2019339732 @default.
- W3198778002 cites W202839665 @default.
- W3198778002 cites W2030132879 @default.
- W3198778002 cites W2030943564 @default.
- W3198778002 cites W2032206270 @default.
- W3198778002 cites W2040664792 @default.
- W3198778002 cites W2044203472 @default.
- W3198778002 cites W2048103330 @default.
- W3198778002 cites W2050706464 @default.
- W3198778002 cites W2055129010 @default.
- W3198778002 cites W2056400855 @default.
- W3198778002 cites W2058108641 @default.
- W3198778002 cites W2058539998 @default.
- W3198778002 cites W2059952163 @default.
- W3198778002 cites W2061330716 @default.
- W3198778002 cites W2066353322 @default.
- W3198778002 cites W2074661552 @default.
- W3198778002 cites W2077744054 @default.
- W3198778002 cites W2082317598 @default.
- W3198778002 cites W2084388603 @default.
- W3198778002 cites W2084566588 @default.
- W3198778002 cites W2084887202 @default.
- W3198778002 cites W2087708225 @default.
- W3198778002 cites W2088318073 @default.
- W3198778002 cites W2096104904 @default.
- W3198778002 cites W2104616840 @default.
- W3198778002 cites W2110114487 @default.
- W3198778002 cites W2113368775 @default.
- W3198778002 cites W2113679292 @default.
- W3198778002 cites W2118661818 @default.
- W3198778002 cites W2123464707 @default.
- W3198778002 cites W2135200424 @default.
- W3198778002 cites W2135747895 @default.
- W3198778002 cites W2140079683 @default.
- W3198778002 cites W2144883297 @default.
- W3198778002 cites W2152666331 @default.
- W3198778002 cites W2157174760 @default.
- W3198778002 cites W2162637085 @default.
- W3198778002 cites W2165499151 @default.
- W3198778002 cites W2171847281 @default.
- W3198778002 cites W2209936824 @default.
- W3198778002 cites W2214358211 @default.
- W3198778002 cites W2227238226 @default.
- W3198778002 cites W2238771054 @default.
- W3198778002 cites W2259460436 @default.
- W3198778002 cites W2270525504 @default.
- W3198778002 cites W2301368457 @default.
- W3198778002 cites W2321579940 @default.
- W3198778002 cites W2345444307 @default.
- W3198778002 cites W2401335316 @default.
- W3198778002 cites W2414352146 @default.
- W3198778002 cites W2469873988 @default.
- W3198778002 cites W2510100774 @default.
- W3198778002 cites W2524968585 @default.
- W3198778002 cites W2541018049 @default.
- W3198778002 cites W2550190802 @default.
- W3198778002 cites W2550657760 @default.
- W3198778002 cites W2554615823 @default.
- W3198778002 cites W2559822346 @default.
- W3198778002 cites W2572710398 @default.
- W3198778002 cites W2594265004 @default.
- W3198778002 cites W2594971526 @default.
- W3198778002 cites W2606246034 @default.
- W3198778002 cites W2700330585 @default.
- W3198778002 cites W2762069773 @default.
- W3198778002 cites W2765520503 @default.
- W3198778002 cites W2775518230 @default.