Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198778895> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3198778895 abstract "Abstract Background: Patients with amnesic mild cognitive impairment (aMCI) are more likely to develop Alzheimer's disease (AD) than corresponding age normal population. Because AD is irreversible, early intervention for aMCI patients seems important and urgent. We have designed a pilot multicenter, randomized, parallel controlled trial to assess the efficacy and safety of acupuncture on aMCI, and explore the feasibility of acupuncture in the treatment of aMCI, so as to provide a reference for large-sample clinical trials in the next stage. Method: We designed a pilot multicenter, randomized, parallel controlled trial. This trial aims to test the feasibility of carrying out a large-sample clinical trial. In this trial, 50 eligible patients with aMCI will be included and allocated to acupuncture group (n = 25) or sham acupuncture group (n = 25) at random. Subjects will accept treatment 2 times a week for 12 weeks continuously, with a total of 24 treatment sessions. We will select six acupoints (GV20, GV14, bilateral BL18 , bilateral BL23). For the clinical outcomes, the primary outcome is Montreal cognitive assessment (MoCA), which will be assessed from baseline to the end of this trial. And the secondary outcomes are Mini-mental State Examination (MMSE), Delayed Story Recall (DSR), Clinical Dementia Rating scale (CDR), Global Deterioration Scale (GDS), Activity of Daily Life (ADL), Alzheimer's Disease Assessment Scale-Cognitive Section (ADAS-cog), brain Magnetic Resonance Imaging (MRI) , brain functional Magnetic Resonance Imaging (fMRI) and Event-related potential (ERP) P300, which will be assessed before and after treatment. In addition, we will asses the safety outcomes from baseline to the end of this trial and feasibility outcome after treatment. We will evaluate neuropsychological assessment scale (MoCA, MMSE, ADAS-cog) at 3 months and 6months after treatment. Discussion: This pilot trial aims to explore the feasibility of the trial, and verify essential information of its efficacy and safety. This pilot study will provide a preliminary basis for carrying out a larger clinical trial of acupuncture on aMCI in near future. Trial registration: Chinese Clinical Trial Registry , ChiCTR1900021557. Registered on 27 February 2019, http://www.chictr.org.cn/showproj.aspx?proj=35460. Keywords: amnestic Mild Cognitive Impairment , Acupuncture, Clinical trial" @default.
- W3198778895 created "2021-09-13" @default.
- W3198778895 creator A5006300020 @default.
- W3198778895 creator A5009616008 @default.
- W3198778895 creator A5032301732 @default.
- W3198778895 creator A5032767214 @default.
- W3198778895 creator A5039907400 @default.
- W3198778895 creator A5049140207 @default.
- W3198778895 creator A5056415424 @default.
- W3198778895 creator A5064869503 @default.
- W3198778895 creator A5089718840 @default.
- W3198778895 date "2020-01-20" @default.
- W3198778895 modified "2023-09-26" @default.
- W3198778895 title "Acupuncture for amnestic mild cognitive impairment (aMCI): study protocol for a pilot multicenter, randomized, parallel controlled trial" @default.
- W3198778895 doi "https://doi.org/10.21203/rs.2.21321/v1" @default.
- W3198778895 hasPublicationYear "2020" @default.
- W3198778895 type Work @default.
- W3198778895 sameAs 3198778895 @default.
- W3198778895 citedByCount "0" @default.
- W3198778895 crossrefType "posted-content" @default.
- W3198778895 hasAuthorship W3198778895A5006300020 @default.
- W3198778895 hasAuthorship W3198778895A5009616008 @default.
- W3198778895 hasAuthorship W3198778895A5032301732 @default.
- W3198778895 hasAuthorship W3198778895A5032767214 @default.
- W3198778895 hasAuthorship W3198778895A5039907400 @default.
- W3198778895 hasAuthorship W3198778895A5049140207 @default.
- W3198778895 hasAuthorship W3198778895A5056415424 @default.
- W3198778895 hasAuthorship W3198778895A5064869503 @default.
- W3198778895 hasAuthorship W3198778895A5089718840 @default.
- W3198778895 hasBestOaLocation W31987788951 @default.
- W3198778895 hasConcept C105795698 @default.
- W3198778895 hasConcept C126322002 @default.
- W3198778895 hasConcept C126838900 @default.
- W3198778895 hasConcept C129848803 @default.
- W3198778895 hasConcept C142724271 @default.
- W3198778895 hasConcept C143409427 @default.
- W3198778895 hasConcept C168563851 @default.
- W3198778895 hasConcept C1862650 @default.
- W3198778895 hasConcept C204787440 @default.
- W3198778895 hasConcept C2776632958 @default.
- W3198778895 hasConcept C2779134260 @default.
- W3198778895 hasConcept C2779483572 @default.
- W3198778895 hasConcept C2780906993 @default.
- W3198778895 hasConcept C2908647359 @default.
- W3198778895 hasConcept C33923547 @default.
- W3198778895 hasConcept C535046627 @default.
- W3198778895 hasConcept C56837625 @default.
- W3198778895 hasConcept C71924100 @default.
- W3198778895 hasConcept C99454951 @default.
- W3198778895 hasConcept C99508421 @default.
- W3198778895 hasConceptScore W3198778895C105795698 @default.
- W3198778895 hasConceptScore W3198778895C126322002 @default.
- W3198778895 hasConceptScore W3198778895C126838900 @default.
- W3198778895 hasConceptScore W3198778895C129848803 @default.
- W3198778895 hasConceptScore W3198778895C142724271 @default.
- W3198778895 hasConceptScore W3198778895C143409427 @default.
- W3198778895 hasConceptScore W3198778895C168563851 @default.
- W3198778895 hasConceptScore W3198778895C1862650 @default.
- W3198778895 hasConceptScore W3198778895C204787440 @default.
- W3198778895 hasConceptScore W3198778895C2776632958 @default.
- W3198778895 hasConceptScore W3198778895C2779134260 @default.
- W3198778895 hasConceptScore W3198778895C2779483572 @default.
- W3198778895 hasConceptScore W3198778895C2780906993 @default.
- W3198778895 hasConceptScore W3198778895C2908647359 @default.
- W3198778895 hasConceptScore W3198778895C33923547 @default.
- W3198778895 hasConceptScore W3198778895C535046627 @default.
- W3198778895 hasConceptScore W3198778895C56837625 @default.
- W3198778895 hasConceptScore W3198778895C71924100 @default.
- W3198778895 hasConceptScore W3198778895C99454951 @default.
- W3198778895 hasConceptScore W3198778895C99508421 @default.
- W3198778895 hasLocation W31987788951 @default.
- W3198778895 hasOpenAccess W3198778895 @default.
- W3198778895 hasPrimaryLocation W31987788951 @default.
- W3198778895 hasRelatedWork W2138743876 @default.
- W3198778895 hasRelatedWork W2141671059 @default.
- W3198778895 hasRelatedWork W2591952757 @default.
- W3198778895 hasRelatedWork W2894662859 @default.
- W3198778895 hasRelatedWork W2911113809 @default.
- W3198778895 hasRelatedWork W2980551103 @default.
- W3198778895 hasRelatedWork W3106960147 @default.
- W3198778895 hasRelatedWork W3112641836 @default.
- W3198778895 hasRelatedWork W3205025735 @default.
- W3198778895 hasRelatedWork W4366603008 @default.
- W3198778895 isParatext "false" @default.
- W3198778895 isRetracted "false" @default.
- W3198778895 magId "3198778895" @default.
- W3198778895 workType "article" @default.