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- W3198804524 abstract "Abstract Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation is closely associated with tumor progression and poor prognosis in several tissues. Additionally, Wnt signaling also influences the tumor microenvironment and immune response. Some strategies and drugs have been proposed to target this pathway, such as blocking receptors/ligands, targeting intracellular molecules, beta-catenin/TCF4 complex and its downstream target genes, or tumor microenvironment and immune response. Here we discuss the roles of these components in Wnt signaling pathway in tumorigenesis and cancer progression, the underlying mechanisms that is responsible for the activation of Wnt signaling, and a series of drugs targeting the Wnt pathway provide multiple therapeutic values. Although some of these drugs exhibit exciting anti-cancer effect, clinical trials and systematic evaluation should be strictly performed along with multiple-omics technology." @default.
- W3198804524 created "2021-09-13" @default.
- W3198804524 creator A5001362787 @default.
- W3198804524 creator A5025065042 @default.
- W3198804524 creator A5025827339 @default.
- W3198804524 creator A5027760008 @default.
- W3198804524 creator A5036552016 @default.
- W3198804524 creator A5049071926 @default.
- W3198804524 creator A5060624379 @default.
- W3198804524 creator A5073212256 @default.
- W3198804524 creator A5080268249 @default.
- W3198804524 creator A5088323463 @default.
- W3198804524 date "2021-09-06" @default.
- W3198804524 modified "2023-10-01" @default.
- W3198804524 title "The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy" @default.
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