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• W3198808885 endingPage "25" @default.
• W3198808885 startingPage "13" @default.
• W3198808885 abstract "In Escherichia coli, several enzymes have been identified that participate in completing replication on the chromosome, including RecG, SbcCD, ExoI, and RecBCD. However, other enzymes are likely to be involved and the precise enzymatic mechanism by which this reaction occurs remains unknown. Two steps predicted to be necessary to complete replication are removal of Okazaki RNA fragments and ligation of the nascent strands at convergent replication forks. E. coli encodes two RNases that remove RNA-DNA hybrids, rnhA and rnhB, as well as two ligases, ligA and ligB. Here, we used replication profiling to show that rnhA and ligA, encoding RNase HI and Ligase A, participate in the completion reaction. Deletion of rnhA impaired the ability to complete replication and resulted in over-replication in the terminus region. It additionally suppressed initiation events from oriC, suggesting a role for the enzyme in oriC-dependent initiation, as has been suggested previously. We also show that a temperature-sensitive mutation in Ligase A led to over-replication at sites where replication completes, and that degradation at these sites occurred upon shifting to the nonpermissive temperature. Deletion of rnhB or ligB did not affect the growth or profile of replication on the genome." @default.
• W3198808885 created "2021-09-13" @default.
• W3198808885 creator A5013252820 @default.
• W3198808885 creator A5024620549 @default.
• W3198808885 creator A5044502246 @default.
• W3198808885 creator A5066453815 @default.
• W3198808885 date "2021-09-03" @default.
• W3198808885 modified "2023-09-27" @default.
• W3198808885 title "Ligase A and RNase HI Participate in Completing Replication on the Chromosome in Escherichia coli" @default.
• W3198808885 cites W148173028 @default.
• W3198808885 cites W1493470226 @default.
• W3198808885 cites W1506272376 @default.
• W3198808885 cites W1513515886 @default.
• W3198808885 cites W1527634644 @default.
• W3198808885 cites W1597820140 @default.
• W3198808885 cites W1625071125 @default.
• W3198808885 cites W1669746447 @default.
• W3198808885 cites W1788241743 @default.
• W3198808885 cites W1804945000 @default.
• W3198808885 cites W1964831588 @default.
• W3198808885 cites W1967705669 @default.
• W3198808885 cites W1968288171 @default.
• W3198808885 cites W1970590693 @default.
• W3198808885 cites W1977843113 @default.
• W3198808885 cites W1979379075 @default.
• W3198808885 cites W1987342864 @default.
• W3198808885 cites W1990308467 @default.
• W3198808885 cites W2003719212 @default.
• W3198808885 cites W2008343350 @default.
• W3198808885 cites W2016430241 @default.
• W3198808885 cites W2018841459 @default.
• W3198808885 cites W2021178020 @default.
• W3198808885 cites W2021279906 @default.
• W3198808885 cites W2024367681 @default.
• W3198808885 cites W2025110183 @default.
• W3198808885 cites W2026297834 @default.
• W3198808885 cites W2028198542 @default.
• W3198808885 cites W2031308486 @default.
• W3198808885 cites W2038853740 @default.
• W3198808885 cites W2040388799 @default.
• W3198808885 cites W2043198662 @default.
• W3198808885 cites W2043375872 @default.
• W3198808885 cites W2044198642 @default.
• W3198808885 cites W2045060907 @default.
• W3198808885 cites W2046540146 @default.
• W3198808885 cites W2047472497 @default.
• W3198808885 cites W2054681032 @default.
• W3198808885 cites W2057242202 @default.
• W3198808885 cites W2060836672 @default.
• W3198808885 cites W2061228928 @default.
• W3198808885 cites W2063743804 @default.
• W3198808885 cites W2064402458 @default.
• W3198808885 cites W2065087573 @default.
• W3198808885 cites W2065688789 @default.
• W3198808885 cites W2065717995 @default.
• W3198808885 cites W2067343931 @default.
• W3198808885 cites W2067728003 @default.
• W3198808885 cites W2069957134 @default.
• W3198808885 cites W2071374581 @default.
• W3198808885 cites W2072859411 @default.
• W3198808885 cites W2074437764 @default.
• W3198808885 cites W2078918509 @default.
• W3198808885 cites W2085454969 @default.
• W3198808885 cites W2092210299 @default.
• W3198808885 cites W2100096652 @default.
• W3198808885 cites W2111967267 @default.
• W3198808885 cites W2115132481 @default.
• W3198808885 cites W2116506800 @default.
• W3198808885 cites W2119669134 @default.
• W3198808885 cites W2119733273 @default.
• W3198808885 cites W2120776332 @default.
• W3198808885 cites W2121001380 @default.
• W3198808885 cites W2121335884 @default.
• W3198808885 cites W2125003792 @default.
• W3198808885 cites W2125553838 @default.
• W3198808885 cites W2125853204 @default.
• W3198808885 cites W2127209192 @default.
• W3198808885 cites W2128485064 @default.
• W3198808885 cites W2132208192 @default.
• W3198808885 cites W2136670217 @default.
• W3198808885 cites W2144463188 @default.
• W3198808885 cites W2144657744 @default.
• W3198808885 cites W2144683765 @default.
• W3198808885 cites W2149568322 @default.
• W3198808885 cites W2149691257 @default.
• W3198808885 cites W2167342214 @default.
• W3198808885 cites W2294294212 @default.
• W3198808885 cites W2409349875 @default.
• W3198808885 cites W2475993022 @default.
• W3198808885 cites W2735410662 @default.
• W3198808885 cites W2773192518 @default.
• W3198808885 cites W2811245672 @default.
• W3198808885 cites W2884917119 @default.
• W3198808885 cites W2891611582 @default.
• W3198808885 cites W2904008336 @default.
• W3198808885 cites W2923222362 @default.
• W3198808885 cites W3198823065 @default.
• W3198808885 cites W574760894 @default.

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