FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198823461> ?p ?o ?g. }

• W3198823461 abstract "Type 2 diabetes causes cardio-renal complications and is treated with different combination therapies. The renal hemodynamics profile of such combination therapies has not been evaluated in detail.Patients (N = 97) with type 2 diabetes were randomized to receive either empagliflozin and linagliptin (E+L group) or metformin and insulin glargine (M+I group) for 3 months. Renal hemodynamics were assessed with para-aminohippuric acid and inulin for renal plasma flow (RPF) and glomerular filtration rate (GFR). Intraglomerular hemodynamics were calculated according the Gomez´ model.Treatment with E+L reduced GFR (p = 0.003), but RPF remained unchanged (p = 0.536). In contrast, M+I not only reduced GFR (p = 0.001), but also resulted in a significant reduction of RPF (p < 0.001). Renal vascular resistance (RVR) decreased with E+L treatment (p = 0.001) but increased with M+I treatment (p = 0.001). The changes in RPF and RVR were different between the two groups (both padjust < 0.001). Analysis of intraglomerular hemodynamics revealed that E+L did not change resistance of afferent arteriole (RA) (p = 0.116), but diminished resistance of efferent arterioles (RE) (p = 0.001). In M+I group RA was increased (p = 0.006) and RE remained unchanged (p = 0.538). The effects on RA (padjust < 0.05) and on RE (padjust < 0.05) differed between the groups.In patients with type 2 diabetes and preserved renal function treatment with M+I resulted in reduction of renal perfusion and increase in vascular resistance, in contrast to treatment with E+I that preserved renal perfusion and reduced vascular resistance. Moreover, different underlying effects on the resistance vessels have been estimated according to the Gomez model, with M+I increasing RA and E+L predominantly decreasing RE, which is in contrast to the proposed sodium-glucose cotransporter 2 inhibitor effects.The study was registered at www.clinicaltrials.gov (NCT02752113) on April 26, 2016." @default.
• W3198823461 created "2021-09-13" @default.
• W3198823461 creator A5001876566 @default.
• W3198823461 creator A5026853750 @default.
• W3198823461 creator A5045274623 @default.
• W3198823461 creator A5048539897 @default.
• W3198823461 creator A5049235067 @default.
• W3198823461 creator A5066875122 @default.
• W3198823461 creator A5072552734 @default.
• W3198823461 creator A5075183492 @default.
• W3198823461 creator A5078953106 @default.
• W3198823461 creator A5091399157 @default.
• W3198823461 date "2021-09-04" @default.
• W3198823461 modified "2023-10-06" @default.
• W3198823461 title "Renal hemodynamic effects differ between antidiabetic combination strategies: randomized controlled clinical trial comparing empagliflozin/linagliptin with metformin/insulin glargine" @default.
• W3198823461 cites W1587661466 @default.
• W3198823461 cites W1990025047 @default.
• W3198823461 cites W2016016054 @default.
• W3198823461 cites W2023984564 @default.
• W3198823461 cites W2044773944 @default.
• W3198823461 cites W2054866483 @default.
• W3198823461 cites W2055395082 @default.
• W3198823461 cites W2068472827 @default.
• W3198823461 cites W2097620901 @default.
• W3198823461 cites W2113401405 @default.
• W3198823461 cites W2136047279 @default.
• W3198823461 cites W2146264128 @default.
• W3198823461 cites W2146351587 @default.
• W3198823461 cites W2289823333 @default.
• W3198823461 cites W2329850142 @default.
• W3198823461 cites W2408641129 @default.
• W3198823461 cites W2409984501 @default.
• W3198823461 cites W2414833236 @default.
• W3198823461 cites W2424539745 @default.
• W3198823461 cites W2473954980 @default.
• W3198823461 cites W2507129113 @default.
• W3198823461 cites W2511998100 @default.
• W3198823461 cites W2518652627 @default.
• W3198823461 cites W2583476095 @default.
• W3198823461 cites W2625241012 @default.
• W3198823461 cites W2884817413 @default.
• W3198823461 cites W2895533920 @default.
• W3198823461 cites W2917112529 @default.
• W3198823461 cites W2940024069 @default.
• W3198823461 cites W2954659053 @default.
• W3198823461 cites W2980268988 @default.
• W3198823461 cites W2994766756 @default.
• W3198823461 cites W3012578900 @default.
• W3198823461 cites W3083935570 @default.
• W3198823461 cites W3101200379 @default.
• W3198823461 cites W3109512796 @default.
• W3198823461 cites W4212827053 @default.
• W3198823461 doi "https://doi.org/10.1186/s12933-021-01358-8" @default.
• W3198823461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8418746" @default.
• W3198823461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34481498" @default.
• W3198823461 hasPublicationYear "2021" @default.
• W3198823461 type Work @default.
• W3198823461 sameAs 3198823461 @default.
• W3198823461 citedByCount "8" @default.
• W3198823461 countsByYear W31988234612021 @default.
• W3198823461 countsByYear W31988234612022 @default.
• W3198823461 countsByYear W31988234612023 @default.
• W3198823461 crossrefType "journal-article" @default.
• W3198823461 hasAuthorship W3198823461A5001876566 @default.
• W3198823461 hasAuthorship W3198823461A5026853750 @default.
• W3198823461 hasAuthorship W3198823461A5045274623 @default.
• W3198823461 hasAuthorship W3198823461A5048539897 @default.
• W3198823461 hasAuthorship W3198823461A5049235067 @default.
• W3198823461 hasAuthorship W3198823461A5066875122 @default.
• W3198823461 hasAuthorship W3198823461A5072552734 @default.
• W3198823461 hasAuthorship W3198823461A5075183492 @default.
• W3198823461 hasAuthorship W3198823461A5078953106 @default.
• W3198823461 hasAuthorship W3198823461A5091399157 @default.
• W3198823461 hasBestOaLocation W31988234611 @default.
• W3198823461 hasConcept C126322002 @default.
• W3198823461 hasConcept C126894567 @default.
• W3198823461 hasConcept C134018914 @default.
• W3198823461 hasConcept C142225936 @default.
• W3198823461 hasConcept C159641895 @default.
• W3198823461 hasConcept C178853913 @default.
• W3198823461 hasConcept C2775887513 @default.
• W3198823461 hasConcept C2777180221 @default.
• W3198823461 hasConcept C2777391703 @default.
• W3198823461 hasConcept C2780031085 @default.
• W3198823461 hasConcept C2780323712 @default.
• W3198823461 hasConcept C555293320 @default.
• W3198823461 hasConcept C58245268 @default.
• W3198823461 hasConcept C71924100 @default.
• W3198823461 hasConceptScore W3198823461C126322002 @default.
• W3198823461 hasConceptScore W3198823461C126894567 @default.
• W3198823461 hasConceptScore W3198823461C134018914 @default.
• W3198823461 hasConceptScore W3198823461C142225936 @default.
• W3198823461 hasConceptScore W3198823461C159641895 @default.
• W3198823461 hasConceptScore W3198823461C178853913 @default.
• W3198823461 hasConceptScore W3198823461C2775887513 @default.
• W3198823461 hasConceptScore W3198823461C2777180221 @default.
• W3198823461 hasConceptScore W3198823461C2777391703 @default.
• W3198823461 hasConceptScore W3198823461C2780031085 @default.
• W3198823461 hasConceptScore W3198823461C2780323712 @default.
• W3198823461 hasConceptScore W3198823461C555293320 @default.

• next