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• W3198901576 abstract "<h3>Background</h3> The unsatisfactory results of the diagnosis and treatment of tuberculosis peritonitis as well as the high rate of disability and mortality in this disease require further study of the pathogenesis of its progression, the features of morphology, and the development of new treatment methods. To this end, we have created a reproducible model of chronic tuberculous peritonitis to study the pathophysiological mechanisms of its development. <h3>Methods</h3> Approved by the Local Ethics Committee, the study was performed using 10 male rabbits of the ‘Soviet Chinchilla’ breed. All the work with model animals was carried out in accordance with international standards for the humane treatment of laboratory animals. Rabbits underwent intraperitoneal administration of mycobacterium tuberculosis (MBT), modeling tuberculosis peritonitis according to our proposed method which included intravenous administration of TNF inhibitor and intraperitoneal inoculation of iron (III) hydroxide of the sucrose complex. As a result, local and general immunosuppression led to active development of MBT in the peritoneum layers causing specific inflammation. The animals were removed from the experiment on the 44th day after infection. Samples of the parietal and visceral peritoneum, intestines, lungs, lymph nodes, parenchymal organs were collected for morphological examination. <h3>Results</h3> During the autopsy of rabbits, the presence of serous-fibrinous effusion, characteristic tubercular formations on the peritoneum, polymorphic adhesive process due to the organization of exudate in the abdominal cavity was noted. It was proved in the experiment that all animals developed tuberculous peritonitis with a lesion of the large omentum and serous integuments of internal organs (IDDF2021-ABS-0013 Figure 1. Autopsy the adhesive process and gray tubercles are disseminated on the parietal and visceral peritoneum)( IDDF2021-ABS-0013 Figure 2. Autopsy gray tubercles on the parietal peritoneum). A molecular genetic study of fragments of the omentum and peritoneum revealed the DNA of mycobacterium tuberculosis. Histological examination of the fragments of the peritoneum and the omentum showed an area of caseous necrosis and granuloma-like clusters of macrophages (IDDF2021-ABS-0013 Figure 3), single clusters of acid-resistant mycobacteria were detected when the preparations were stained according to Ziehl-Neelsen. <h3>Conclusions</h3> The developed method of modeling tuberculosis peritonitis is close to the real human disease in clinical and morphological manifestations and allows us to study the dynamics and mechanisms of the development of a specific infectious process in the abdominal cavity." @default.
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• W3198901576 date "2021-09-01" @default.
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• W3198901576 title "IDDF2021-ABS-0013 The method for obtaining a reproducible model of tuberculous peritonitis in rabbits" @default.
• W3198901576 doi "https://doi.org/10.1136/gutjnl-2021-iddf.21" @default.
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