FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198930383> ?p ?o ?g. }

• W3198930383 endingPage "101219" @default.
• W3198930383 startingPage "101219" @default.
• W3198930383 abstract "It has been known for decades that circRNAs are deregulated in cancer. Here, we characterized the role and underlying mechanism of circ_0088212 in osteosarcoma.The expression levels of circ_0088212, miR-520 h, and APOA1 were determined by RT-qPCR. RNase R digestion was performed to verify the circular structure of circ_0088212. CCK8 and transwell invasion assays were conducted to examine the in vitro malignancy of osteosarcoma. Caspase-3 activity was also measured. An in vivo model of osteosarcoma was constructed to examine the in vivo effect of circ_0088212 on osteosarcoma. Luciferase reporter, RNA RIP, and RNA pull-down assays were performed to verify the interaction between miR-520 h and APOA1 or circ_0088212.Circ_0088212 and APOA1 were expressed at low levels in osteosarcoma tissues and cells, while miR-520 h was highly expressed. Overexpression of circ_0088212 was found to inhibit the in vitro and in vivo growth of osteosarcoma. Mechanistically, miR-520 h was the target of circ_0088212 and APOA1 was the target of miR-520 h. Circ_0088212 downregulated miR-520 h expression, while miR-520 h overexpression abolished the inhibitory effect of circ_0088212 on osteosarcoma cell proliferation and migration. Furthermore, miR-520 h overexpression led to reduced APOA1 expression, while APOA1 overexpression counteracted the oncogenic effect of miR-520 h in osteosarcoma cells.Our findings demonstrated that circ_0088212 might exert a tumor-suppressive activity in osteosarcoma by sponging and sequestering miR-520 h away from APOA1. This suggests that the circ_0088212/miR-520 h/APOA1 axis may be a promising therapeutic target for osteosarcoma intervention." @default.
• W3198930383 created "2021-09-27" @default.
• W3198930383 creator A5017773158 @default.
• W3198930383 creator A5021306721 @default.
• W3198930383 creator A5036060468 @default.
• W3198930383 creator A5060470951 @default.
• W3198930383 date "2021-12-01" @default.
• W3198930383 modified "2023-09-28" @default.
• W3198930383 title "Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression" @default.
• W3198930383 cites W1561071487 @default.
• W3198930383 cites W1977282006 @default.
• W3198930383 cites W1995975317 @default.
• W3198930383 cites W2252671082 @default.
• W3198930383 cites W2336651787 @default.
• W3198930383 cites W2522803584 @default.
• W3198930383 cites W2581834730 @default.
• W3198930383 cites W2608190552 @default.
• W3198930383 cites W2764294957 @default.
• W3198930383 cites W2767053399 @default.
• W3198930383 cites W2775185528 @default.
• W3198930383 cites W2889164950 @default.
• W3198930383 cites W2914790254 @default.
• W3198930383 cites W2938281554 @default.
• W3198930383 cites W2953520588 @default.
• W3198930383 cites W2964889307 @default.
• W3198930383 cites W2967448688 @default.
• W3198930383 cites W2981630366 @default.
• W3198930383 cites W2994662728 @default.
• W3198930383 cites W2997275868 @default.
• W3198930383 cites W3015215695 @default.
• W3198930383 cites W3016070117 @default.
• W3198930383 cites W3045329680 @default.
• W3198930383 cites W3086670038 @default.
• W3198930383 doi "https://doi.org/10.1016/j.tranon.2021.101219" @default.
• W3198930383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8461379" @default.
• W3198930383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34555726" @default.
• W3198930383 hasPublicationYear "2021" @default.
• W3198930383 type Work @default.
• W3198930383 sameAs 3198930383 @default.
• W3198930383 citedByCount "9" @default.
• W3198930383 countsByYear W31989303832022 @default.
• W3198930383 countsByYear W31989303832023 @default.
• W3198930383 crossrefType "journal-article" @default.
• W3198930383 hasAuthorship W3198930383A5017773158 @default.
• W3198930383 hasAuthorship W3198930383A5021306721 @default.
• W3198930383 hasAuthorship W3198930383A5036060468 @default.
• W3198930383 hasAuthorship W3198930383A5060470951 @default.
• W3198930383 hasBestOaLocation W31989303831 @default.
• W3198930383 hasConcept C104317684 @default.
• W3198930383 hasConcept C10879258 @default.
• W3198930383 hasConcept C111335760 @default.
• W3198930383 hasConcept C127561419 @default.
• W3198930383 hasConcept C145059251 @default.
• W3198930383 hasConcept C150903083 @default.
• W3198930383 hasConcept C153911025 @default.
• W3198930383 hasConcept C185592680 @default.
• W3198930383 hasConcept C190283241 @default.
• W3198930383 hasConcept C202751555 @default.
• W3198930383 hasConcept C207001950 @default.
• W3198930383 hasConcept C2777760704 @default.
• W3198930383 hasConcept C502942594 @default.
• W3198930383 hasConcept C54009773 @default.
• W3198930383 hasConcept C55493867 @default.
• W3198930383 hasConcept C62112901 @default.
• W3198930383 hasConcept C67705224 @default.
• W3198930383 hasConcept C86803240 @default.
• W3198930383 hasConceptScore W3198930383C104317684 @default.
• W3198930383 hasConceptScore W3198930383C10879258 @default.
• W3198930383 hasConceptScore W3198930383C111335760 @default.
• W3198930383 hasConceptScore W3198930383C127561419 @default.
• W3198930383 hasConceptScore W3198930383C145059251 @default.
• W3198930383 hasConceptScore W3198930383C150903083 @default.
• W3198930383 hasConceptScore W3198930383C153911025 @default.
• W3198930383 hasConceptScore W3198930383C185592680 @default.
• W3198930383 hasConceptScore W3198930383C190283241 @default.
• W3198930383 hasConceptScore W3198930383C202751555 @default.
• W3198930383 hasConceptScore W3198930383C207001950 @default.
• W3198930383 hasConceptScore W3198930383C2777760704 @default.
• W3198930383 hasConceptScore W3198930383C502942594 @default.
• W3198930383 hasConceptScore W3198930383C54009773 @default.
• W3198930383 hasConceptScore W3198930383C55493867 @default.
• W3198930383 hasConceptScore W3198930383C62112901 @default.
• W3198930383 hasConceptScore W3198930383C67705224 @default.
• W3198930383 hasConceptScore W3198930383C86803240 @default.
• W3198930383 hasIssue "12" @default.
• W3198930383 hasLocation W31989303831 @default.
• W3198930383 hasLocation W31989303832 @default.
• W3198930383 hasLocation W31989303833 @default.
• W3198930383 hasLocation W31989303834 @default.
• W3198930383 hasLocation W31989303835 @default.
• W3198930383 hasOpenAccess W3198930383 @default.
• W3198930383 hasPrimaryLocation W31989303831 @default.
• W3198930383 hasRelatedWork W1553867384 @default.
• W3198930383 hasRelatedWork W2573992804 @default.
• W3198930383 hasRelatedWork W2781680339 @default.
• W3198930383 hasRelatedWork W2907903807 @default.
• W3198930383 hasRelatedWork W2980649317 @default.
• W3198930383 hasRelatedWork W3048663729 @default.

• next