Matches in SemOpenAlex for { <https://semopenalex.org/work/W3198986075> ?p ?o ?g. }
- W3198986075 abstract "Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform a multi-platform molecular characterization. We identify major subgroups characterized by genomic instability (GI) or activation of epithelial-mesenchymal-transition (EMT)-like programs, which subdivide into non-inflammatory and inflammatory subtypes. GI CLL exhibit disruption of genome integrity, DNA-damage response and are associated with mutagenesis mediated through activation-induced cytidine deaminase or defective mismatch repair. TP53 wild-type and mutated/deleted cases constitute a transcriptionally uniform entity in GI CLL and show similarly poor progression-free survival at relapse. EMT-like CLL exhibit high genomic stability, reduced benefit from the addition of rituximab and EMT-like differentiation is inhibited by induction of DNA damage. This work extends the perspective on CLL biology and risk categories in TP53 wild-type CLL. Furthermore, molecular targets identified within each subgroup provide opportunities for new treatment approaches." @default.
- W3198986075 created "2021-09-27" @default.
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- W3198986075 date "2021-09-13" @default.
- W3198986075 modified "2023-10-10" @default.
- W3198986075 title "Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia" @default.
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