Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199023742> ?p ?o ?g. }
- W3199023742 abstract "Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes." @default.
- W3199023742 created "2021-09-27" @default.
- W3199023742 creator A5045629350 @default.
- W3199023742 creator A5051313310 @default.
- W3199023742 creator A5054837831 @default.
- W3199023742 date "2021-09-13" @default.
- W3199023742 modified "2023-10-14" @default.
- W3199023742 title "Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes" @default.
- W3199023742 cites W1530997192 @default.
- W3199023742 cites W1536660914 @default.
- W3199023742 cites W1549955232 @default.
- W3199023742 cites W157068544 @default.
- W3199023742 cites W1585770671 @default.
- W3199023742 cites W1599776525 @default.
- W3199023742 cites W1709882622 @default.
- W3199023742 cites W1861454855 @default.
- W3199023742 cites W1896602542 @default.
- W3199023742 cites W1968436520 @default.
- W3199023742 cites W1968448831 @default.
- W3199023742 cites W1969258192 @default.
- W3199023742 cites W1972701428 @default.
- W3199023742 cites W1973044435 @default.
- W3199023742 cites W1973424799 @default.
- W3199023742 cites W1981925657 @default.
- W3199023742 cites W1984762682 @default.
- W3199023742 cites W1990434622 @default.
- W3199023742 cites W1991305069 @default.
- W3199023742 cites W1994526435 @default.
- W3199023742 cites W1996676082 @default.
- W3199023742 cites W1996772309 @default.
- W3199023742 cites W2001114434 @default.
- W3199023742 cites W2006919788 @default.
- W3199023742 cites W2008477650 @default.
- W3199023742 cites W2013751658 @default.
- W3199023742 cites W2019275415 @default.
- W3199023742 cites W2025734854 @default.
- W3199023742 cites W2029481352 @default.
- W3199023742 cites W2029940162 @default.
- W3199023742 cites W2032472678 @default.
- W3199023742 cites W2036136783 @default.
- W3199023742 cites W2037190164 @default.
- W3199023742 cites W2040072827 @default.
- W3199023742 cites W2046151130 @default.
- W3199023742 cites W2046785412 @default.
- W3199023742 cites W2050739080 @default.
- W3199023742 cites W2050977906 @default.
- W3199023742 cites W2053386318 @default.
- W3199023742 cites W2055529939 @default.
- W3199023742 cites W2055598943 @default.
- W3199023742 cites W2056664487 @default.
- W3199023742 cites W2056778426 @default.
- W3199023742 cites W2060915038 @default.
- W3199023742 cites W2061994098 @default.
- W3199023742 cites W2068188137 @default.
- W3199023742 cites W2069758360 @default.
- W3199023742 cites W2070806097 @default.
- W3199023742 cites W2075798069 @default.
- W3199023742 cites W2076618616 @default.
- W3199023742 cites W2079937591 @default.
- W3199023742 cites W2088689860 @default.
- W3199023742 cites W2089842862 @default.
- W3199023742 cites W2091769425 @default.
- W3199023742 cites W2097877954 @default.
- W3199023742 cites W2098855695 @default.
- W3199023742 cites W2103302057 @default.
- W3199023742 cites W2106816266 @default.
- W3199023742 cites W2107844390 @default.
- W3199023742 cites W2108040825 @default.
- W3199023742 cites W2114810988 @default.
- W3199023742 cites W2116511498 @default.
- W3199023742 cites W2117973345 @default.
- W3199023742 cites W2118597504 @default.
- W3199023742 cites W2126598873 @default.
- W3199023742 cites W2130476194 @default.
- W3199023742 cites W2137937946 @default.
- W3199023742 cites W2144187890 @default.
- W3199023742 cites W2148890861 @default.
- W3199023742 cites W2149738778 @default.
- W3199023742 cites W2152841620 @default.
- W3199023742 cites W2153535157 @default.
- W3199023742 cites W2158461247 @default.
- W3199023742 cites W2159228347 @default.
- W3199023742 cites W2159693066 @default.
- W3199023742 cites W2162120036 @default.
- W3199023742 cites W2165262973 @default.
- W3199023742 cites W2166550261 @default.
- W3199023742 cites W2170353553 @default.
- W3199023742 cites W2171017604 @default.
- W3199023742 cites W2171678230 @default.
- W3199023742 cites W2217612575 @default.
- W3199023742 cites W2285005685 @default.
- W3199023742 cites W2315814529 @default.
- W3199023742 cites W2316199514 @default.
- W3199023742 cites W2328786770 @default.
- W3199023742 cites W2337348862 @default.
- W3199023742 cites W2339916182 @default.
- W3199023742 cites W2341414956 @default.
- W3199023742 cites W2427171630 @default.
- W3199023742 cites W2427433249 @default.
- W3199023742 cites W2562591732 @default.