Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199038170> ?p ?o ?g. }
- W3199038170 endingPage "2403" @default.
- W3199038170 startingPage "2393" @default.
- W3199038170 abstract "Hypothyroidism has been reported to be associated with cognitive decline. Considering the role of folic acid (FA) in cognitive performance, the present study was designed to investigate the effects of FA on hypothyroidism-induced cognitive impairment, oxidative damage, and alterations in acetylcholinesterase (AChE) activity in rat model of propylthiouracil (PTU)-induced hypothyroidism. In this study, PTU (0.05% in drinking water) and FA (5, 10, and 15 mg/kg, oral gavage) were administered for the rats during 7 weeks. Then, behavioral performance was tested using Morris water maze (MWM) and passive avoidance (PA) tasks. Finally, oxidative stress indicators and AChE activity were assayed in the brain tissues. The impairing effect of hypothyroidism on cognitive performance was markedly alleviated by FA especially at higher doses. In the MWM test, FA reduced escape latency and travelled distance, compared to the non-treated hypothyroid group. In the PA test, latency to enter dark chamber was significantly enhanced by FA compared to the non-treated hypothyroid group (p < 0.05-p < 0.001). Besides, FA attenuated AChE activity and malondialdehyde level but it increased activity of superoxide dismutase enzyme and total thiol content (p < 0.05-p < 0.001). In conclusion, our findings revealed that FA could improve learning and memory ability in hypothyroid rats. The observed protective effects may have been mediated through regulation of oxidative stress and AChE activity." @default.
- W3199038170 created "2021-09-27" @default.
- W3199038170 creator A5019998658 @default.
- W3199038170 creator A5031480779 @default.
- W3199038170 creator A5049656801 @default.
- W3199038170 creator A5062604082 @default.
- W3199038170 creator A5065248617 @default.
- W3199038170 creator A5081215156 @default.
- W3199038170 creator A5090107697 @default.
- W3199038170 date "2021-09-25" @default.
- W3199038170 modified "2023-10-03" @default.
- W3199038170 title "Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats" @default.
- W3199038170 cites W194801233 @default.
- W3199038170 cites W1968162860 @default.
- W3199038170 cites W1971048984 @default.
- W3199038170 cites W1979030149 @default.
- W3199038170 cites W1980152507 @default.
- W3199038170 cites W1983015515 @default.
- W3199038170 cites W1990465508 @default.
- W3199038170 cites W2003982930 @default.
- W3199038170 cites W2016671624 @default.
- W3199038170 cites W2019523275 @default.
- W3199038170 cites W2041388209 @default.
- W3199038170 cites W2043851006 @default.
- W3199038170 cites W2047625958 @default.
- W3199038170 cites W2054052970 @default.
- W3199038170 cites W2064922969 @default.
- W3199038170 cites W2068583548 @default.
- W3199038170 cites W2069511021 @default.
- W3199038170 cites W2071484175 @default.
- W3199038170 cites W2084692086 @default.
- W3199038170 cites W2091773788 @default.
- W3199038170 cites W2092524179 @default.
- W3199038170 cites W2112607478 @default.
- W3199038170 cites W2121768598 @default.
- W3199038170 cites W2168545953 @default.
- W3199038170 cites W2205955397 @default.
- W3199038170 cites W2417659148 @default.
- W3199038170 cites W2514959060 @default.
- W3199038170 cites W2519832108 @default.
- W3199038170 cites W2556267855 @default.
- W3199038170 cites W2556604975 @default.
- W3199038170 cites W2577440683 @default.
- W3199038170 cites W2613407339 @default.
- W3199038170 cites W2768156122 @default.
- W3199038170 cites W2779151730 @default.
- W3199038170 cites W2784781506 @default.
- W3199038170 cites W2794738875 @default.
- W3199038170 cites W2804675788 @default.
- W3199038170 cites W2892739123 @default.
- W3199038170 cites W2899618917 @default.
- W3199038170 cites W2942498501 @default.
- W3199038170 cites W2994899302 @default.
- W3199038170 cites W910436092 @default.
- W3199038170 doi "https://doi.org/10.1007/s11011-021-00815-3" @default.
- W3199038170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34562187" @default.
- W3199038170 hasPublicationYear "2021" @default.
- W3199038170 type Work @default.
- W3199038170 sameAs 3199038170 @default.
- W3199038170 citedByCount "9" @default.
- W3199038170 countsByYear W31990381702022 @default.
- W3199038170 countsByYear W31990381702023 @default.
- W3199038170 crossrefType "journal-article" @default.
- W3199038170 hasAuthorship W3199038170A5019998658 @default.
- W3199038170 hasAuthorship W3199038170A5031480779 @default.
- W3199038170 hasAuthorship W3199038170A5049656801 @default.
- W3199038170 hasAuthorship W3199038170A5062604082 @default.
- W3199038170 hasAuthorship W3199038170A5065248617 @default.
- W3199038170 hasAuthorship W3199038170A5081215156 @default.
- W3199038170 hasAuthorship W3199038170A5090107697 @default.
- W3199038170 hasBestOaLocation W31990381702 @default.
- W3199038170 hasConcept C126322002 @default.
- W3199038170 hasConcept C134018914 @default.
- W3199038170 hasConcept C15744967 @default.
- W3199038170 hasConcept C181199279 @default.
- W3199038170 hasConcept C185592680 @default.
- W3199038170 hasConcept C2775838275 @default.
- W3199038170 hasConcept C2775960720 @default.
- W3199038170 hasConcept C2776151105 @default.
- W3199038170 hasConcept C2778401633 @default.
- W3199038170 hasConcept C2778816929 @default.
- W3199038170 hasConcept C2779059548 @default.
- W3199038170 hasConcept C2781161787 @default.
- W3199038170 hasConcept C44752575 @default.
- W3199038170 hasConcept C526584372 @default.
- W3199038170 hasConcept C55493867 @default.
- W3199038170 hasConcept C71924100 @default.
- W3199038170 hasConceptScore W3199038170C126322002 @default.
- W3199038170 hasConceptScore W3199038170C134018914 @default.
- W3199038170 hasConceptScore W3199038170C15744967 @default.
- W3199038170 hasConceptScore W3199038170C181199279 @default.
- W3199038170 hasConceptScore W3199038170C185592680 @default.
- W3199038170 hasConceptScore W3199038170C2775838275 @default.
- W3199038170 hasConceptScore W3199038170C2775960720 @default.
- W3199038170 hasConceptScore W3199038170C2776151105 @default.
- W3199038170 hasConceptScore W3199038170C2778401633 @default.
- W3199038170 hasConceptScore W3199038170C2778816929 @default.
- W3199038170 hasConceptScore W3199038170C2779059548 @default.