FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3199040776> ?p ?o ?g. }

• W3199040776 endingPage "950" @default.
• W3199040776 startingPage "940" @default.
• W3199040776 abstract "Deregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynthesis pathway enzymes SMOX and PAOX, as well as the histone demethylase LSD1. Based on our previous research in acute myeloid leukemia (AML), we reasoned verlindamycin may also unblock neuroblastoma differentiation when combined with all-trans-retinoic acid (ATRA). Indeed, co-treatment with verlindamycin and ATRA strongly induced differentiation regardless of MYCN status, but in MYCN-expressing cells, protein levels were strongly diminished. This process was not transcriptionally regulated but was due to increased degradation of MYCN protein, at least in part via ubiquitin-independent, proteasome-dependent destruction. Here we report that verlindamycin effectively induces the expression of functional tumor suppressor-antizyme via ribosomal frameshifting. Consistent with previous results describing the function of antizyme, we found that verlindamycin treatment led to the selective targeting of ornithine decarboxylase (the rate-limiting enzyme for polyamine biosynthesis) as well as key oncoproteins, such as cyclin D and Aurora A kinase. Retinoid-based multimodal differentiation therapy is one of the few interventions that extends relapse-free survival in MYCN-associated high-risk neuroblastoma and these results point toward the potential use of verlindamycin in this regimen." @default.
• W3199040776 created "2021-09-27" @default.
• W3199040776 creator A5001379166 @default.
• W3199040776 creator A5006578843 @default.
• W3199040776 creator A5028318497 @default.
• W3199040776 creator A5032468367 @default.
• W3199040776 creator A5033170809 @default.
• W3199040776 creator A5045885328 @default.
• W3199040776 creator A5046028725 @default.
• W3199040776 creator A5064760601 @default.
• W3199040776 creator A5065006459 @default.
• W3199040776 creator A5069134408 @default.
• W3199040776 creator A5077704860 @default.
• W3199040776 date "2021-09-14" @default.
• W3199040776 modified "2023-10-11" @default.
• W3199040776 title "The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme" @default.
• W3199040776 cites W1495632188 @default.
• W3199040776 cites W1603797292 @default.
• W3199040776 cites W1842046684 @default.
• W3199040776 cites W1939176039 @default.
• W3199040776 cites W1975255784 @default.
• W3199040776 cites W1983015568 @default.
• W3199040776 cites W1986194331 @default.
• W3199040776 cites W1993181584 @default.
• W3199040776 cites W1995474832 @default.
• W3199040776 cites W2000615535 @default.
• W3199040776 cites W2022665654 @default.
• W3199040776 cites W2024280594 @default.
• W3199040776 cites W2027542963 @default.
• W3199040776 cites W2028953339 @default.
• W3199040776 cites W2041165692 @default.
• W3199040776 cites W2051570559 @default.
• W3199040776 cites W2061850969 @default.
• W3199040776 cites W2064428081 @default.
• W3199040776 cites W2064462911 @default.
• W3199040776 cites W2098356010 @default.
• W3199040776 cites W2109378990 @default.
• W3199040776 cites W2120450507 @default.
• W3199040776 cites W2132855064 @default.
• W3199040776 cites W2139752108 @default.
• W3199040776 cites W2145927254 @default.
• W3199040776 cites W2152460980 @default.
• W3199040776 cites W2318284531 @default.
• W3199040776 cites W2327522594 @default.
• W3199040776 cites W2466354473 @default.
• W3199040776 cites W2602591481 @default.
• W3199040776 cites W2607693344 @default.
• W3199040776 cites W2692768525 @default.
• W3199040776 cites W2733406733 @default.
• W3199040776 cites W2786740949 @default.
• W3199040776 cites W2790070205 @default.
• W3199040776 cites W2891375035 @default.
• W3199040776 cites W3036877880 @default.
• W3199040776 cites W3087297916 @default.
• W3199040776 cites W834960855 @default.
• W3199040776 doi "https://doi.org/10.1038/s41417-021-00386-6" @default.
• W3199040776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34522028" @default.
• W3199040776 hasPublicationYear "2021" @default.
• W3199040776 type Work @default.
• W3199040776 sameAs 3199040776 @default.
• W3199040776 citedByCount "3" @default.
• W3199040776 countsByYear W31990407762022 @default.
• W3199040776 countsByYear W31990407762023 @default.
• W3199040776 crossrefType "journal-article" @default.
• W3199040776 hasAuthorship W3199040776A5001379166 @default.
• W3199040776 hasAuthorship W3199040776A5006578843 @default.
• W3199040776 hasAuthorship W3199040776A5028318497 @default.
• W3199040776 hasAuthorship W3199040776A5032468367 @default.
• W3199040776 hasAuthorship W3199040776A5033170809 @default.
• W3199040776 hasAuthorship W3199040776A5045885328 @default.
• W3199040776 hasAuthorship W3199040776A5046028725 @default.
• W3199040776 hasAuthorship W3199040776A5064760601 @default.
• W3199040776 hasAuthorship W3199040776A5065006459 @default.
• W3199040776 hasAuthorship W3199040776A5069134408 @default.
• W3199040776 hasAuthorship W3199040776A5077704860 @default.
• W3199040776 hasBestOaLocation W31990407761 @default.
• W3199040776 hasConcept C104317684 @default.
• W3199040776 hasConcept C108905728 @default.
• W3199040776 hasConcept C121289238 @default.
• W3199040776 hasConcept C181199279 @default.
• W3199040776 hasConcept C185592680 @default.
• W3199040776 hasConcept C2776601000 @default.
• W3199040776 hasConcept C2776715637 @default.
• W3199040776 hasConcept C2779982571 @default.
• W3199040776 hasConcept C2780115381 @default.
• W3199040776 hasConcept C2781121885 @default.
• W3199040776 hasConcept C502942594 @default.
• W3199040776 hasConcept C54355233 @default.
• W3199040776 hasConcept C55493867 @default.
• W3199040776 hasConcept C81885089 @default.
• W3199040776 hasConcept C86803240 @default.
• W3199040776 hasConcept C95444343 @default.
• W3199040776 hasConceptScore W3199040776C104317684 @default.
• W3199040776 hasConceptScore W3199040776C108905728 @default.
• W3199040776 hasConceptScore W3199040776C121289238 @default.
• W3199040776 hasConceptScore W3199040776C181199279 @default.
• W3199040776 hasConceptScore W3199040776C185592680 @default.
• W3199040776 hasConceptScore W3199040776C2776601000 @default.

• next